INT49835

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 4.11
Pain Relevance 20.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
medulla 7
neurons 4
pons 3
nucleus accumbens 2
neuronal 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 311 100.00 Very High Very High Very High
mu opioid receptor 120 100.00 Very High Very High Very High
narcan 80 100.00 Very High Very High Very High
Glutamate 27 100.00 Very High Very High Very High
MU agonist 18 100.00 Very High Very High Very High
Nucleus accumbens 9 100.00 Very High Very High Very High
Morphine 192 99.98 Very High Very High Very High
Opioid 208 99.96 Very High Very High Very High
agonist 40 99.96 Very High Very High Very High
gABA 27 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 76 99.52 Very High Very High Very High
Nociception 17 99.24 Very High Very High Very High
Urological Neuroanatomy 30 98.36 Very High Very High Very High
Ganglion Cysts 13 97.52 Very High Very High Very High
Nervous System Injury 3 94.64 High High
Pain 42 94.08 High High
Targeted Disruption 19 89.40 High High
Neuropathic Pain 7 84.20 Quite High
Apoptosis 5 75.92 Quite High
Opiate Addiction 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, corticostriatal EPSCs were inhibited by MOR activation to similar extents in the two compartments, although inhibition of IPSCs was observed only in the striosomes.
Negative_regulation (inhibited) of Positive_regulation (activation) of MOR associated with opioid receptor
1) Confidence 0.42 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17804632 Disease Relevance 0.08 Pain Relevance 0.50
However, upregulation of MOR mRNA levels in the nucleus accumbens core were reduced by methadone maintenance in a dose-dependent manner.
Negative_regulation (reduced) of Positive_regulation (upregulation) of MOR mRNA in nucleus accumbens associated with nucleus accumbens, methadone and opioid receptor
2) Confidence 0.42 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16237390 Disease Relevance 0.15 Pain Relevance 1.77
Basal promoter activity of Oprm1 is positioned at ?
Negative_regulation (positioned) of Positive_regulation (activity) of Oprm1
3) Confidence 0.42 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
CP3 protein repressed about 40% of the Oprm1 proximal promoter activity induced in pcDNA4 vector only-transfected cells (Fig. 5).


Negative_regulation (repressed) of Positive_regulation (induced) of Oprm1 in proximal
4) Confidence 0.42 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
Loss of mu-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of mu-opioid receptor gene.
Negative_regulation (Loss) of Positive_regulation (activation) of mu-opioid receptor in pons associated with medulla and opioid receptor
5) Confidence 0.42 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12459506 Disease Relevance 0.32 Pain Relevance 0.59
Inhibition on MOR mediated activation is observed after in vitro NE administration as well.
Negative_regulation (Inhibition) of Positive_regulation (activation) of MOR associated with opioid receptor
6) Confidence 0.41 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17698254 Disease Relevance 0.18 Pain Relevance 1.06
Noladin ether, a putative endocannabinoid, inhibits mu-opioid receptor activation via CB2 cannabinoid receptors.
Negative_regulation (inhibits) of Positive_regulation (activation) of mu-opioid receptor associated with endocannabinoid, cannabinoid receptor and opioid receptor
7) Confidence 0.40 Published 2008 Journal Neurochem. Int. Section Title Doc Link 17698254 Disease Relevance 0.12 Pain Relevance 0.95
A specific protein kinase C inhibitor, calphostin C, which injected alone had no effect on the antinociception induced by intrathecal (i.t.) administration of a selective mu-opioid receptor agonist, [D-Ala2,NMePhe4,Gly(ol)5]enkephalin (DAMGO), dose-dependently attenuated the development of acute tolerance to the i.t.
Negative_regulation (administration) of Positive_regulation (selective) of mu-opioid receptor associated with antinociception, tolerance, agonist, enkephalin, opioid receptor, intrathecal and kinase c inhibitor
8) Confidence 0.40 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7589170 Disease Relevance 0 Pain Relevance 1.02
The neutral antagonist 6 beta-naltrexol blocked MOR activation without affecting basal signaling (G protein coupling and adenylyl cyclase regulation) and also elicited substantially less severe withdrawal.
Negative_regulation (blocked) of Positive_regulation (activation) of MOR associated with antagonist and withdrawal
9) Confidence 0.37 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600246 Disease Relevance 0.13 Pain Relevance 1.07
In these mice, inheritance of the CXBK mu-OR gene was well correlated with less mu-OR mRNA and reduced opioid effects on nociception and locomotor activity.
Negative_regulation (reduced) of Positive_regulation (inheritance) of CXBK mu-OR gene associated with nociception, eae and opioid
10) Confidence 0.37 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11160404 Disease Relevance 0.10 Pain Relevance 0.82
The early increase in MOR mRNA could be completely prevented by local anesthetic blockade of neuronal conduction in sciatic nerve.
Negative_regulation (prevented) of Positive_regulation (increase) of MOR mRNA in neuronal associated with sciatic nerve, opioid receptor and local anesthetic
11) Confidence 0.29 Published 2004 Journal Neuroscience Section Abstract Doc Link 15501604 Disease Relevance 0.39 Pain Relevance 1.22
Physiological studies have suggested that mu-opioid receptor (MOR) activation can both excite and inhibit reticulospinal neurons in the rostral ventrolateral medulla (RVL), possibly via influences on GABAergic neurons.
Negative_regulation (inhibit) of Positive_regulation (activation) of mu-opioid receptor in medulla associated with rostral ventrolateral medulla, gabaergic and opioid receptor
12) Confidence 0.23 Published 2001 Journal Brain Res. Section Abstract Doc Link 11602225 Disease Relevance 0 Pain Relevance 0.68
Physiological studies have suggested that mu-opioid receptor (MOR) activation can both excite and inhibit reticulospinal neurons in the rostral ventrolateral medulla (RVL), possibly via influences on GABAergic neurons.
Negative_regulation (inhibit) of Positive_regulation (activation) of MOR in medulla associated with rostral ventrolateral medulla, gabaergic and opioid receptor
13) Confidence 0.23 Published 2001 Journal Brain Res. Section Abstract Doc Link 11602225 Disease Relevance 0 Pain Relevance 0.68
As observed for Akt, the morphine-activated MOR also recruited inactive nNOS to reduce the stamina of the Akt-nNOS pathway.
Negative_regulation (recruited) of Positive_regulation (activated) of MOR associated with opioid receptor and morphine
14) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.21 Pain Relevance 1.11
These data demonstrate that MOP-R activation decreases GABA and increases GLU release in the RVM.
Negative_regulation (decreases) of Positive_regulation (activation) of MOP-R in RVM associated with glutamate, gaba and rostral ventromedial medulla
15) Confidence 0.22 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17961151 Disease Relevance 0 Pain Relevance 1.21
However, naloxone pretreatment did not prevent Fos activation of MOR neurons, suggesting that Fos induction was not the result of MOR activation.
Negative_regulation (prevent) of Positive_regulation (activation) of MOR in neurons associated with mu opioid receptor and narcan
16) Confidence 0.21 Published 2004 Journal Neuroscience Section Abstract Doc Link 14960335 Disease Relevance 0.34 Pain Relevance 0.86
Loss of mu-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of mu-opioid receptor gene.
Negative_regulation (Loss) of in medulla Positive_regulation (activation) of mu-opioid receptor in pons associated with medulla and opioid receptor
17) Confidence 0.14 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12459506 Disease Relevance 0.32 Pain Relevance 0.59
We tested this by comparing complementary chemical sequelae of long-term morphine treatment among cells in which short-term MOR activation inhibited instead of stimulated AC activity.
Negative_regulation (inhibited) of Positive_regulation (activation) of MOR associated with opioid receptor and morphine
18) Confidence 0.11 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18045853 Disease Relevance 0 Pain Relevance 0.90
Decreased activation of MOR on injured primary afferent central terminals and the second order neurons they innervate may minimize any reduction by opioids of the spontaneous pain mediated by ectopic input from axotomized small diameter afferents.
Negative_regulation (Decreased) of Positive_regulation (activation) of MOR in neurons associated with pain, spontaneous pain, mu opioid receptor and opioid
19) Confidence 0.08 Published 2005 Journal Pain Section Abstract Doc Link 16098668 Disease Relevance 0.70 Pain Relevance 1.27
This was evidenced by blocking neuronal conduction with local anesthetic, which prevented the upregulation of MOR mRNA in the first 2 hours following induction of inflammation in the rat hind paw (Puehler et al 2004).


Negative_regulation (prevented) of Positive_regulation (upregulation) of MOR mRNA in paw associated with inflammation and local anesthetic
20) Confidence 0.07 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 1.07 Pain Relevance 1.27

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