INT4991

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 74
Total Number 74
Disease Relevance 69.84
Pain Relevance 8.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vim) structural molecule activity (Vim) plasma membrane (Vim)
cytoskeleton (Vim) nucleus (Vim) biological_process (Vim)
Anatomy Link Frequency
smooth muscle 10
neuron 9
muscle 4
stromal cells 3
spindle cells 2
Vim (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 16 99.88 Very High Very High Very High
Pain 40 98.96 Very High Very High Very High
Inflammation 35 98.92 Very High Very High Very High
substance P 1 96.96 Very High Very High Very High
imagery 31 96.52 Very High Very High Very High
Enkephalin 5 96.28 Very High Very High Very High
pain pelvic 3 94.36 High High
cva 13 94.00 High High
cerebral cortex 2 92.92 High High
endometriosis 14 92.56 High High
Disease Link Frequency Relevance Heat
Cancer 436 99.90 Very High Very High Very High
Sarcoma 61 99.90 Very High Very High Very High
Cv Unclassified Under Development 12 99.88 Very High Very High Very High
Multiple System Atrophy 6 99.82 Very High Very High Very High
Gastrointestinal Stromal Tumor 40 99.80 Very High Very High Very High
Synovial Sarcoma 15 99.80 Very High Very High Very High
Meningioma 7 99.70 Very High Very High Very High
Cleidocranial Dysplasia 12 99.64 Very High Very High Very High
Disease 95 99.56 Very High Very High Very High
Leiomyosarcoma 97 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of the Vim nucleus might have had a pain relieving effects because no facial paraesthesiae was evoked by stimulation.
Positive_regulation (Stimulation) of Vim in nucleus associated with pain
1) Confidence 0.69 Published 1991 Journal Acta Neurochir Suppl (Wien) Section Abstract Doc Link 1792955 Disease Relevance 0.43 Pain Relevance 0.46
Immunohistochemically, the tumor cells of these epithelial islands gave a constant positive reaction for cytokeratin as well as vimentin, while the stromal cells in the osteofibrous dysplasia-like lesion were positive for vimentin only.
Positive_regulation (positive) of vimentin in stromal cells associated with cancer and cleidocranial dysplasia
2) Confidence 0.68 Published 1991 Journal Pathol. Res. Pract. Section Abstract Doc Link 1724319 Disease Relevance 1.31 Pain Relevance 0.08
Immunohistochemical studies confirmed the diagnosis of meningioma with positive reactions for epithelial membrane antigen (79%) and vimentin (100%).
Positive_regulation (reactions) of vimentin associated with meningioma
3) Confidence 0.49 Published 2003 Journal Mod. Pathol. Section Abstract Doc Link 12640104 Disease Relevance 1.82 Pain Relevance 0.11
Immunohistochemically, the tumor cells of these epithelial islands gave a constant positive reaction for cytokeratin as well as vimentin, while the stromal cells in the osteofibrous dysplasia-like lesion were positive for vimentin only.
Positive_regulation (reaction) of vimentin in stromal cells associated with cancer and cleidocranial dysplasia
4) Confidence 0.49 Published 1991 Journal Pathol. Res. Pract. Section Abstract Doc Link 1724319 Disease Relevance 1.32 Pain Relevance 0.08
CD 34 and Vimentin were positive and cytokeratin was negative in this case.
Positive_regulation (positive) of Vimentin
5) Confidence 0.27 Published 1999 Journal Kyobu Geka Section Abstract Doc Link 10554495 Disease Relevance 0.78 Pain Relevance 0.09
Upon immunohistochemistry, the epithelial tumor was positive for cytokeratin and negative for vimentin and the endothelial tumor was negative for cytokeratin and positive for vimentin.
Positive_regulation (negative) of vimentin associated with cancer
6) Confidence 0.25 Published 2010 Journal Vet Ophthalmol Section Abstract Doc Link 20149179 Disease Relevance 0.97 Pain Relevance 0.09
Immunohistochemical study showed that the atypical cells were strongly reactive for vimentin and negative for CD68, while the giant cells were immunoreactive for CD68, but negative for vimentin.
Positive_regulation (negative) of vimentin
7) Confidence 0.25 Published 2002 Journal Int. J. Clin. Oncol. Section Abstract Doc Link 12494256 Disease Relevance 0.68 Pain Relevance 0.08
Immunohistochemical studies revealed that all the tumors were variably positive for cytokeratins 8, 18, and 19, and epithelial membrane antigen but negative for vimentin.
Positive_regulation (negative) of vimentin associated with cancer
8) Confidence 0.25 Published 1995 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 7573686 Disease Relevance 1.30 Pain Relevance 0.06
Immunohistochemical stains of the tumors were positive for vimentin but negative for epithelial markers, differentiating these lesions from other hepatic tumors.
Positive_regulation (positive) of vimentin associated with cancer
9) Confidence 0.25 Published 1994 Journal South. Med. J. Section Abstract Doc Link 7510907 Disease Relevance 2.17 Pain Relevance 0.07
Histopathology showed a GIST that was positive for c-kit and vimentin and negative for desmin and smooth muscle actin.
Positive_regulation (positive) of vimentin in smooth muscle associated with gastrointestinal stromal tumor
10) Confidence 0.25 Published 2003 Journal Gynecol. Oncol. Section Abstract Doc Link 14675690 Disease Relevance 0.79 Pain Relevance 0.14
Immunohistochemistry was positive for vimentin and negative for thyroglobulin.
Positive_regulation (positive) of vimentin
11) Confidence 0.25 Published 2006 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16553038 Disease Relevance 0.79 Pain Relevance 0.18
Various proportions of plasma cells, histiocytes, and spindle cells were observed; the latter corresponded ultrastructurally to fibroblasts and myofibroblasts, were immunoreactive for vimentin and actin and focally for desmin, and were negative for epithelial markers.
Positive_regulation (immunoreactive) of vimentin in spindle cells
12) Confidence 0.25 Published 1990 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 2239820 Disease Relevance 0.79 Pain Relevance 0.16
Immunohistochemical study showed the tumor cells were strongly positive for CD34 and vimentin, but negative for epithelial membrane antigen.
Positive_regulation (positive) of vimentin associated with cancer
13) Confidence 0.25 Published 2000 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 11153198 Disease Relevance 0.88 Pain Relevance 0.08
Immunohistochemical study showed that the atypical cells were strongly reactive for vimentin and negative for CD68, while the giant cells were immunoreactive for CD68, but negative for vimentin.
Positive_regulation (reactive) of vimentin
14) Confidence 0.25 Published 2002 Journal Int. J. Clin. Oncol. Section Abstract Doc Link 12494256 Disease Relevance 0.68 Pain Relevance 0.08
Contrasting with control rats, vimentin immunostaining was now associated with both SON astrocytes and capillary vessels, whereas vessels located in the surrounding brain regions remained vimentin-negative (Fig. 5E).
Positive_regulation (remained) of vimentin-negative in vessels
15) Confidence 0.25 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemistry showed that the neoplastic cells were negative for glial fibrillary acid protein, and slightly positive for vimentin and cytokeratin.
Positive_regulation (positive) of vimentin
16) Confidence 0.24 Published 2004 Journal J. Vet. Med. Sci. Section Abstract Doc Link 15472485 Disease Relevance 0.34 Pain Relevance 0.16
Macrophage staining (EB1) and fibroblast staining (vimentin) were significantly increased prior to incision.
Positive_regulation (increased) of vimentin in fibroblast
17) Confidence 0.21 Published 2000 Journal J. Surg. Res. Section Body Doc Link 10864475 Disease Relevance 0.06 Pain Relevance 0
Immunohistochemically, the tumor cells were positive for anti-epithelial membrane antigen, vimentin, desmin, neuron-specific enolase and WT1 protein antibodies.
Positive_regulation (positive) of vimentin in neuron associated with cancer
18) Confidence 0.21 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849332 Disease Relevance 0.98 Pain Relevance 0.08
At 7 days of recovery, significant increases in immature astrocytes were observed in the ILH, as assessed by increased vimentin, S100b and GFAP staining (Fig. 1E,G) compared to the CLH (Fig. 1D,F).
Positive_regulation (increased) of vimentin in astrocytes
19) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0
The tumor cells had intracytoplasmic mucin and positive immunoreactivity for carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin; but they were negative for S-100 protein and vimentin.
Positive_regulation (negative) of vimentin associated with cancer
20) Confidence 0.14 Published 1991 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 1718175 Disease Relevance 1.09 Pain Relevance 0.08

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