INT49978

Context Info Confidence 0.39 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.11 Pain Relevance 1.29

transport (Hbb)

Anatomy Link Frequency brain 1 Hbb (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 2 99.30 Enkephalin 1 99.30 Opioid 2 98.16 cva 11 93.84 Pain 15 93.04 Potency 1 76.44 opioid receptor 1 71.60 Somatosensory cortex 1 56.24 anesthesia 1 25.00 Inflammation 3 5.00

Disease Link Frequency Relevance Heat Toxicity 55 99.40 Cv General 3 Under Development 12 93.84 Pain 8 88.88 Acidosis 1 68.72 Alkalosis 1 67.76 Poisoning 32 5.00 Stress 29 5.00 Cancer 10 5.00 Iron Overload 10 5.00 Lead Poisoning 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results obtained from additional experiments were found to correlate closely to those obtained using other tests (e.g. in vitro hemoglobin release test, and in vivo creatine kinase release test in rabbits).

Localization (release) of hemoglobin

1) Confidence 0.39 Published 1994 Journal J Pharm Sci Technol Section Abstract Doc Link 8069518 Disease Relevance 0.46 Pain Relevance 0.61

BOLD fMRI localizes activated brain areas by measuring decreases of deoxygenated hemoglobin (deoxy-Hb) caused by neurovascular coupling.

Localization (decreases) of hemoglobin in brain

2) Confidence 0.38 Published 2010 Journal Neuroimage Section Abstract Doc Link 20420930 Disease Relevance 0.41 Pain Relevance 0.23

VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides.

Localization (released) of hemoglobin associated with enkephalin

3) Confidence 0.05 Published 1995 Journal Neuropeptides Section Title Doc Link 7596489 Disease Relevance 0 Pain Relevance 0.44

A chemical entity that qualifies as an ideal chelator in vitro might not prove so in vivo, either due to the toxicity considerations or due to the presence of endogenous substances (hemoglobin, cytochromes, etc.) that can also chelate metal ions and thus offer competition.

Localization (presence) of hemoglobin associated with toxicity

4) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2922724 Disease Relevance 0.24 Pain Relevance 0

General Comments

This test has worked.