INT50050

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Context Info
Confidence 0.76
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 16.84
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CSRP1)
Anatomy Link Frequency
white blood cell 4
liver 2
blood 1
plasma 1
retina 1
CSRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 5 100.00 Very High Very High Very High
Inflammation 86 99.92 Very High Very High Very High
Crohn's disease 6 99.38 Very High Very High Very High
Restless leg syndrome 240 98.80 Very High Very High Very High
spinal inflammation 12 97.84 Very High Very High Very High
Pain 29 97.08 Very High Very High Very High
aspirin 44 96.20 Very High Very High Very High
Inflammatory response 32 94.80 High High
epidural 1 94.24 High High
Angina 2 87.56 High High
Disease Link Frequency Relevance Heat
Low Back Pain 5 100.00 Very High Very High Very High
INFLAMMATION 139 99.92 Very High Very High Very High
Leukocytosis 2 99.90 Very High Very High Very High
Diabetes Mellitus 6 99.64 Very High Very High Very High
Disease 35 99.38 Very High Very High Very High
Fever 12 99.04 Very High Very High Very High
Hemianopsia 1 99.00 Very High Very High Very High
Ganglion Cysts 24 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 257 98.80 Very High Very High Very High
Peripheral Arterial Disease 13 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WBC count was 5400 and CRP was negative and temperature was 36.2 degrees C.
Neg (negative) Gene_expression (negative) of CRP in WBC
1) Confidence 0.76 Published 1993 Journal No Shinkei Geka Section Abstract Doc Link 8327054 Disease Relevance 0.69 Pain Relevance 0.07
Islet1 is a homeotic LIM-domain transcription factor that is known to be expressed by bipolar, horizontal, and ganglion cells in the retina [29].
Gene_expression (expressed) of LIM-domain in retina associated with ganglion cysts
2) Confidence 0.75 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.19 Pain Relevance 0
In comparison to a control group, only a higher CRP was determined and also a 35 years higher age average.
Spec (determined) Gene_expression (determined) of CRP
3) Confidence 0.68 Published 2009 Journal Rozhl Chir Section Body Doc Link 19526946 Disease Relevance 0.11 Pain Relevance 0
Most patients presented with back pain and elevated CRP.
Gene_expression (presented) of CRP associated with backache
4) Confidence 0.67 Published 2009 Journal Intern Med J Section Abstract Doc Link 20233246 Disease Relevance 0.63 Pain Relevance 0.18
Average of CRP was 4.00 mg/dL before surgery and 1.88 mg/dL at postoperative 1 week.
Gene_expression (Average) of CRP
5) Confidence 0.66 Published 2007 Journal Spine Section Body Doc Link 17224815 Disease Relevance 0 Pain Relevance 0
After the second cycle, the levels of leukocytes and CRP were remarkably decreased, and the severe back pain was also alleviated.
Gene_expression (levels) of CRP in leukocytes associated with backache
6) Confidence 0.60 Published 2003 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 12722684 Disease Relevance 0.54 Pain Relevance 0.19
These patients were not on statin therapy which has been shown to reduce IL-6 and CRP production in the endothelial and liver cells [26,27].
Gene_expression (production) of CRP in liver
7) Confidence 0.58 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.07 Pain Relevance 0.76
With the treatment with antibiotics, 5-aminosalicylic acid, steroid, and azathioprine, as a whole, decreasing pattern and intermittent fine coordinated fluctuation of the levels of amylase and lipase along with the decrease of Crohn's disease activity index (CDAI) and the CRP levels were observed.
Gene_expression (levels) of CRP associated with crohn's disease and disease
8) Confidence 0.54 Published 2009 Journal Korean J Gastroenterol Section Abstract Doc Link 19381059 Disease Relevance 1.10 Pain Relevance 0.30
No statistical correlation was found between p40 IL12/40 serum levels and each of BASDAI, ESR, CRP, serum levels of IL 17, MMP 3.
Gene_expression (levels) of CRP
9) Confidence 0.51 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.29
The following parameters were measured: plasma interleukin-6 (IL-6), high sensitivity CRP (hsCRP), white blood cell count, thrombin-anti-thrombin complex (TAT) and fibrin D-Dimer (fDD), urinary protein creatinine ratio (PCR), ACR and NAG.


Gene_expression (measured) of CRP in white blood cell
10) Confidence 0.50 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.49 Pain Relevance 0.48
The following parameters were measured: plasma interleukin-6 (IL-6), high sensitivity CRP (hsCRP), white blood cell count, thrombin-anti-thrombin complex (TAT) and fibrin D-Dimer (fDD), urinary protein creatinine ratio (PCR), ACR and NAG.


Gene_expression (measured) of hsCRP in white blood cell
11) Confidence 0.44 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.49 Pain Relevance 0.48
Baseline hsCRP values were higher in patients with IC compared to volunteers (p = 0.035).
Gene_expression (values) of hsCRP associated with restless leg syndrome
12) Confidence 0.44 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.60 Pain Relevance 0.60
P40 IL12/23 was assessed using Human Quantikine ELISA (R&D Systems), and at the same time, BASDAI, ESR, CRP, IL-17, MMP-3.
Gene_expression (assessed) of CRP
13) Confidence 0.44 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.42 Pain Relevance 0.22
Whereas significant reduction in BASDAI, ESR, and CRP were obvious after treatment, there was no significant change in serum level of p40 IL12/23.
Gene_expression (reduction) of CRP
14) Confidence 0.44 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.51 Pain Relevance 0.28
Laboratory data on admission revealed elevated serum levels of CRP, GOT, GPT, LDH, CK, and troponin-I with hypo gamma-globulinemia.
Gene_expression (levels) of CRP
15) Confidence 0.43 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20608087 Disease Relevance 0.86 Pain Relevance 0.14
No statistical correlation was found between p40 IL12/40 serum levels and each of BASDAI, ESR, CRP, serum levels of IL 17, MMP 3.
Gene_expression (levels) of CRP
16) Confidence 0.39 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.52 Pain Relevance 0.29
Earlier studies have consistently shown elevated white cell counts in the peripheral blood, with predominant polymorphonuclear leukocytosis and raised CRP and ESR during the attacks.
Gene_expression (raised) of CRP in blood associated with leukocytosis
17) Confidence 0.38 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 2.04 Pain Relevance 0.15
Indicated by distinct signals of CD68, CD40 and CRP, inflammation was present in 5/21 (24%), 3/21 (14%) and 2/21 (10%) of ISR cases.
Gene_expression (signals) of CRP associated with inflammation and cardiovascular disease
18) Confidence 0.33 Published 2004 Journal J. Vasc. Res. Section Abstract Doc Link 15528935 Disease Relevance 1.96 Pain Relevance 0.24
IL-6 also stimulates the production of acute-phase proteins, including C-reactive protein (CRP), which can predict cardiovascular risk (Ridker et al. 2000).
Gene_expression (production) of CRP
19) Confidence 0.31 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.16 Pain Relevance 0.08
His skin lesions were continued to improve, normalizing peripheral white blood cell counts, serum levels of CRP and the liver function.
Gene_expression (levels) of CRP in liver
20) Confidence 0.18 Published 1995 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 7602194 Disease Relevance 1.18 Pain Relevance 0.15

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