INT50077

From wiki-pain
Revision as of 12:19, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 7.68
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Myb) DNA binding (Myb)
Anatomy Link Frequency
finger 2
CPA 1
colon 1
spinal cord 1
ganglion 1
Myb (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 13 99.70 Very High Very High Very High
Spinal cord 2 99.36 Very High Very High Very High
anesthesia 36 99.00 Very High Very High Very High
Morphine 7 98.80 Very High Very High Very High
abdominal pain 2 94.48 High High
intrathecal 1 94.16 High High
local anesthetic 2 75.00 Quite High
opiate 1 70.24 Quite High
adenocard 1 64.56 Quite High
Inflammation 43 55.12 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 99.84 Very High Very High Very High
Osteogenic Sarcomas 10 99.72 Very High Very High Very High
Cancer 911 99.36 Very High Very High Very High
Cleidocranial Dysplasia 31 99.32 Very High Very High Very High
Myopia 130 99.04 Very High Very High Very High
Adamantinoma 93 98.76 Very High Very High Very High
Gastrointestinal Stromal Tumor 6 98.48 Very High Very High Very High
Colorectal Cancer 160 97.72 Very High Very High Very High
Injury 23 97.20 Very High Very High Very High
Targeted Disruption 18 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myb (also called c-myb) expression was induced by diffuser treatment and to an even higher extent by filter wear.
Gene_expression (expression) of c-myb
1) Confidence 0.66 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.54 Pain Relevance 0
Krt2-6b, Myb, and Dock4 expression
Gene_expression (expression) of Myb
2) Confidence 0.66 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.33 Pain Relevance 0
However, the differential expression of Dock4 (p=0.07) and Myb (p=0.09) just missed significance, and the differential expression of Usp36 and Zmym4 also could not be confirmed.
Gene_expression (expression) of Myb
3) Confidence 0.66 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.08 Pain Relevance 0
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Gene_expression (selected) of Myb in finger associated with osteogenic sarcomas
4) Confidence 0.66 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
Myb expression was hardly detectable in the control group and therefore seems to be induced by the treatment conditions.
Gene_expression (expression) of Myb
5) Confidence 0.66 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
Myb (also called c-myb) expression was induced by diffuser treatment and to an even higher extent by filter wear.
Gene_expression (expression) of Myb
6) Confidence 0.66 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.55 Pain Relevance 0
Myb is expressed in ganglion, amacrine, horizontal, and photoreceptor cells of adult mice, suggesting that it might play a role in the physiology of retinal cells [67].
Gene_expression (expressed) of Myb in ganglion associated with ganglion cysts
7) Confidence 0.66 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.64 Pain Relevance 0
Those differentially expressed in TG versus NTG cells included not only ALDH1A1, as described above (Figure 3C), but also c-Myb (MYB) and c-Myc (MYC; Figure 4B).
Gene_expression (expressed) of MYB
8) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.49 Pain Relevance 0
Those differentially expressed in TG versus NTG cells included not only ALDH1A1, as described above (Figure 3C), but also c-Myb (MYB) and c-Myc (MYC; Figure 4B).
Gene_expression (expressed) of c-Myb
9) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.49 Pain Relevance 0
Proto-oncogenes such as c-Myb not only coordinate normal development of the distal colon, but altered expression is commonly associated with hyperproliferation of immature colorectal cells and overt cancer [37], [45]. c-Myc has recently been demonstrated to mediate nuclear ?
Gene_expression (expression) of c-Myb in colon associated with cancer
10) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.60 Pain Relevance 0
These observations corroborate past studies demonstrating the association of the MYB and MYC proto-oncogenes with cancer, but underscore the distinction between TG versus NTG cells, in that those cells most resistant to therapy (i.e.
Gene_expression (proto) of MYB associated with cancer
11) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.63 Pain Relevance 0
ALDH1A1, MYC, and MYB are enriched in residual TG cells post CPA therapy
Gene_expression (enriched) of MYB in CPA
12) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.36 Pain Relevance 0
Baseline expression levels of Akt2, Krt2-6b, Myb, Zmym4, Usp36, and Dock4
Gene_expression (levels) of Myb
13) Confidence 0.51 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
Baseline expression levels of Akt2, Krt2-6b, Myb, Zmym4, Usp36, and Dock4
Gene_expression (expression) of Myb
14) Confidence 0.51 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Gene_expression (selected) of myeloblastosis oncogene in finger associated with osteogenic sarcomas
15) Confidence 0.50 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
It was first discovered that both c-myb and c-myc mRNA expression in splenocytes of repetitive Mor-treated mice were detected to be significantly decreased, and that GPP could induce restoration of several immunologic parameters depressed by Mor treatment to or even beyond normal levels.
Gene_expression (expression) of c-myb associated with morphine
16) Confidence 0.38 Published 1995 Journal Sheng Li Ke Xue Jin Zhan Section Abstract Doc Link 7604222 Disease Relevance 0 Pain Relevance 0.70
In addition to Pax-3, other TREs such as: PITX2, CDP, and c-Myb were also found over-represented (figure 5).
Gene_expression (represented) of c-Myb
17) Confidence 0.12 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.48 Pain Relevance 0
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastro intestinal tract and express the c-kit proto-oncogene protein (CD-117).
Gene_expression (express) of proto-oncogene protein associated with cancer and gastrointestinal stromal tumor
18) Confidence 0.07 Published 2006 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 17802947 Disease Relevance 0.79 Pain Relevance 0.09
To understand the biochemical mechanisms involved in spinal anesthesia, we measured protein kinase C (PKC) activity and expression of immediate early oncogene protein, c-Fos, in the spinal cord.
Gene_expression (expression) of oncogene protein in spinal cord associated with kinase c, anesthesia and spinal cord
19) Confidence 0.05 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.71
Remarkably, upon IGF-1 treatment, CREB1 also showed up-regulation in the TranSignal Cell Growth Protein DNA Array (Panomics Inc.), which includes AP1, c-Myb, CREB (miRBase predicted miR-103 target), E2F-1, EGR, Ets, FKHR, Myc-Max, NE-E1 (YY1), NF-?
Gene_expression (includes) of c-Myb
20) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox