INT50139

Context Info Confidence 0.50 First Reported 1995 Last Reported 2009 Negated 2 Speculated 3 Reported most in Body Documents 6 Total Number 9 Disease Relevance 3.50 Pain Relevance 2.39

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)

Anatomy Link Frequency spinal 2 lung 2 mast cells 2 Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 24 100.00 corticosteroid 9 99.96 cINOD 17 99.56 Inflammation 379 99.16 aspirin 7 98.14 dexamethasone 8 96.32 Hyperalgesia 1 91.96 allodynia 1 91.28 Spinal cord 3 84.68 Multiple sclerosis 62 79.48

Disease Link Frequency Relevance Heat INFLAMMATION 400 99.16 Hypersensitivity 10 98.68 Asthma 87 96.28 Hyperalgesia 1 91.96 Neuropathic Pain 2 91.28 Multiple Sclerosis 35 84.08 Demyelinating Disease 84 79.48 Disorder Of Lipid Metabolism 4 55.76 Sprains And Strains 2 55.64 Disease 15 55.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Prednisone did not alter PGD2 synthesis during the cutaneous late-phase allergic response in humans [40].

Neg (not) Regulation (alter) of Gene_expression (synthesis) of PGD2 associated with hypersensitivity

1) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.71 Pain Relevance 0.67

Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors.

Regulation (Effect) of Gene_expression (expression) of PGD2 in spinal associated with cytokine

2) Confidence 0.44 Published 2008 Journal J. Neurochem. Section Title Doc Link 18028337 Disease Relevance 0.34 Pain Relevance 0.45

How do commonly used anti-inflammatory agents, such as NSAIDs and corticosteroids, affect PGD2 levels?

Regulation (affect) of Gene_expression (levels) of PGD2 associated with corticosteroid, inflammation and cinod

3) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.65 Pain Relevance 0.62

Exudate IL-6, PGE2 and PGD2 levels were determined by commercially available immunoassays (eBioscience, San Diego, CA, USA (IL-6) and Cayman Chemical, Ann Arbor, MI, USA (PGE2 and PGD2)).

Spec (determined) Regulation (Exudate) of Gene_expression (levels) of PGD2

4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.05 Pain Relevance 0

Exudate IL-6, PGE2 and PGD2 levels were determined by commercially available immunoassays (eBioscience, San Diego, CA, USA (IL-6) and Cayman Chemical, Ann Arbor, MI, USA (PGE2 and PGD2)).

Spec (determined) Regulation (determined) of Gene_expression (levels) of PGD2

5) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.05 Pain Relevance 0

Finally, it is noteworthy that our unchanged levels of hPGD synthase suggest that PGD2 production was probably unaffected [54], and, therefore, that the impact of this PG on the oligonucleotide-induced changes was limited.

Neg (unaffected) Spec (probably) Regulation (unaffected) of Gene_expression (production) of PGD2

6) Confidence 0.39 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.66 Pain Relevance 0.16

Expression of mPGE synthase and hPGD synthase in the lung

Regulation (lung) of Gene_expression (Expression) of hPGD synthase in lung

7) Confidence 0.33 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.25 Pain Relevance 0.07

The initial PGD2 burst in activated MMC-34 cells is prevented by aspirin pretreatment, suggesting that constitutive PGS-1 present in mast cells before activation is responsible for the early PGD2 production in response to activation.

Regulation (responsible) of Gene_expression (production) of PGD2 in mast cells associated with aspirin

8) Confidence 0.23 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0.09 Pain Relevance 0.23

antiangiogenic activities stemming from PGD2 production within

Regulation (stemming) of Gene_expression (production) of PGD2

9) Confidence 0.15 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.70 Pain Relevance 0.19

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