INT50149

Context Info Confidence 0.61 First Reported 1995 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 13 Disease Relevance 4.88 Pain Relevance 2.73

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)

Anatomy Link Frequency monocytes 3 neuronal 2 neutrophils 2 mast cell 2 macrophages 1 Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat dexamethasone 24 99.98 Inflammation 86 99.96 cytokine 17 99.44 chemokine 34 92.16 cINOD 19 91.44 Pain 6 90.64 Inflammatory response 5 80.64 aspirin 11 78.76 Spinal cord 2 76.04 allodynia 1 69.36

Disease Link Frequency Relevance Heat INFLAMMATION 102 99.96 Targeted Disruption 12 99.92 Cancer 14 97.92 Adenoma 6 96.72 Pain 8 90.64 Nociception 3 82.28 Colon Cancer 4 81.00 Injury 10 79.04 Adhesions 32 69.84 Neuropathic Pain 1 69.36

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Anatomy

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Speculation

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Dexamethasone induces lipocalin-type prostaglandin D synthase gene expression in mouse neuronal cells.

Positive_regulation (induces) of Gene_expression (expression) of prostaglandin D synthase gene in neuronal associated with dexamethasone

1) Confidence 0.61 Published 2000 Journal J. Neurochem. Section Title Doc Link 10899920 Disease Relevance 0.16 Pain Relevance 0.34

An initial rapid burst of PGD2 synthesis, complete within 30 min, is followed by a slower subsequent production of PGD2 that reaches a maximum 4 to 8 h after activation in MMC-34 cells.

Positive_regulation (followed) of Gene_expression (synthesis) of PGD2

2) Confidence 0.48 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0 Pain Relevance 0.06

It can be assumed, that PGD2 biosynthesis under control conditions is mediated via COX-1 and that during inflammation, increased PGD2 is dependent on COX-2.

Positive_regulation (mediated) of Gene_expression (biosynthesis) of PGD2 associated with inflammation

3) Confidence 0.45 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.30 Pain Relevance 0.32

The provision of exogenous PGD2 but not PGD3 (which could be derived from EPA), fully restored the ability of neutrophils to cross the endothelial cell monolayer (Figure 7A).

Positive_regulation (derived) of Gene_expression (provision) of PGD2 in neutrophils

4) Confidence 0.45 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.08 Pain Relevance 0.14

In contrast, in acute peritoneal inflammation, knockout of PGD2 synthase increased inflammatory cytokine production and retarded the rate of inflammatory resolution by a mechanism that operated through the DP-1 receptor [24].

Positive_regulation (increased) of Gene_expression (synthase) of PGD2 associated with targeted disruption, inflammation and cytokine

5) Confidence 0.45 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 1.34 Pain Relevance 0.71

These data demonstrate that mast cell activation results 1) in the induction of PGS-2 gene expression, and 2) in both PGS-1-dependent PGD2 synthesis and PGD2 synthesis that is dependent on the activation-induced synthesis and activity of PGS-2.

Positive_regulation (dependent) of Gene_expression (synthesis) of PGD2 in mast cell

6) Confidence 0.44 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0.09 Pain Relevance 0.21

An initial rapid burst of PGD2 synthesis, complete within 30 min, is followed by a slower subsequent production of PGD2 that reaches a maximum 4 to 8 h after activation in MMC-34 cells.

Positive_regulation (followed) of Gene_expression (production) of PGD2

7) Confidence 0.42 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0 Pain Relevance 0.06

An initial rapid burst of PGD2 synthesis, complete within 30 min, is followed by a slower subsequent production of PGD2 that reaches a maximum 4 to 8 h after activation in MMC-34 cells.

Positive_regulation (reaches) of Gene_expression (production) of PGD2

8) Confidence 0.42 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0 Pain Relevance 0.06

An initial rapid burst of PGD2 synthesis, complete within 30 min, is followed by a slower subsequent production of PGD2 that reaches a maximum 4 to 8 h after activation in MMC-34 cells.

Positive_regulation (subsequent) of Gene_expression (production) of PGD2

9) Confidence 0.42 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0 Pain Relevance 0.06

It is interesting that the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA), which induces the synthesis of PGs in many tissues, inhibited the increase in L-PGDS expression induced by dexamethasone.

Positive_regulation (increase) of Gene_expression (expression) of L-PGDS associated with cancer and dexamethasone

10) Confidence 0.41 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10899920 Disease Relevance 0.17 Pain Relevance 0.38

By immunohistochemistry, we detected hematopoietic PGD synthase mainly in macrophages and monocytes of the gut mucosa.

Positive_regulation (detected) of Gene_expression (detected) of PGD synthase in monocytes

11) Confidence 0.31 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17283118 Disease Relevance 1.16 Pain Relevance 0.11

By immunohistochemistry, we detected hematopoietic PGD synthase mainly in macrophages and monocytes of the gut mucosa.

Positive_regulation (detected) of in macrophages Gene_expression (detected) of PGD synthase in monocytes

12) Confidence 0.10 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17283118 Disease Relevance 1.16 Pain Relevance 0.11

Synthase enzymes then convert PGH2 to specific prostaglandins such as PGD2, PGE2, PGF2?

Positive_regulation (convert) of Gene_expression (prostaglandins) of PGD2

13) Confidence 0.09 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154427 Disease Relevance 0.43 Pain Relevance 0.15

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