INT50314

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 0.19
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
head 1
htr (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 8 100.00 Very High Very High Very High
noradrenaline 4 100.00 Very High Very High Very High
tramadol 14 99.98 Very High Very High Very High
Cannabinoid 30 99.92 Very High Very High Very High
agonist 13 99.86 Very High Very High Very High
Potency 15 99.48 Very High Very High Very High
fluoxetine 9 99.26 Very High Very High Very High
Morphine 2 98.76 Very High Very High Very High
depression 4 96.96 Very High Very High Very High
antagonist 18 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 4 96.96 Very High Very High Very High
Thyroid Disease 2 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low
Tourette's Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induced HTR was depressed by pretreatment with cycloheptadine, p-chlorophenylalanine or fluoxetine, but was potentiated by 5,7-dihydroxytryptamine.
Negative_regulation (depressed) of HTR associated with fluoxetine
1) Confidence 0.51 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7617148 Disease Relevance 0 Pain Relevance 0.18
HU-210 was the most potent inhibitor of HTR, whereas CP 55,940 was most effective against ESR.
Negative_regulation (inhibitor) of HTR
2) Confidence 0.46 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11267636 Disease Relevance 0 Pain Relevance 0.52
Haloperidol can inhibit DOI-induced HTR in mice, but fluoxetine can not.


Negative_regulation (inhibit) of HTR
3) Confidence 0.38 Published 2007 Journal Zhongguo Dang Dai Er Ke Za Zhi Section Body Doc Link 17937861 Disease Relevance 0 Pain Relevance 0
The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls.
Negative_regulation (inhibitor) of HTR in head associated with desipramine, antidepressant, depression, noradrenaline, serotonin and fluoxetine
4) Confidence 0.36 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16530230 Disease Relevance 0.10 Pain Relevance 0.48
In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR.
Negative_regulation (number) of HTR
5) Confidence 0.36 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16530230 Disease Relevance 0.09 Pain Relevance 0.47
The purpose of the present study was to: (1) investigate whether Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and its analogs [Delta(8)-tetrahydrocannabinol (Delta(8)-THC), HU-210, CP 55,940, and WIN 55,212-2] can prevent the DOI-induced behaviors and (2) to see whether any correlation exists in the ID(50) potency order of these cannabinoids in inhibiting the DOI-induced HTR and ESR relative to their published ED(50) potency profiles in producing the tetrad of behaviors in mice.
Negative_regulation (inhibiting) of HTR associated with cannabinoid and potency
6) Confidence 0.34 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11267636 Disease Relevance 0 Pain Relevance 0.41
The ID(50) potency order of cannabinoids in blocking the HTR is: HU-210 > CP 55,940 > WIN 55,212-2 > Delta(9)-THC > Delta(8)-THC, which is identical to their published order of potency in producing the tetrad of behaviors in mice.
Negative_regulation (blocking) of HTR associated with cannabinoid and potency
7) Confidence 0.34 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11267636 Disease Relevance 0 Pain Relevance 0.48
Tramadol attenuated 5-HTP-induced HTR in a dose-dependent manner as morphine.
Negative_regulation (attenuated) of HTR associated with tramadol and morphine
8) Confidence 0.23 Published 2003 Journal Life Sci. Section Abstract Doc Link 12570923 Disease Relevance 0 Pain Relevance 1.23
In conclusion, administration of tramadol systemically inhibits 5-HTP-induced HTR in mice by activating opiatergic system in the CNS.
Negative_regulation (inhibits) of HTR associated with tramadol
9) Confidence 0.23 Published 2003 Journal Life Sci. Section Abstract Doc Link 12570923 Disease Relevance 0 Pain Relevance 1.28
Pretreatment with fluoxetine (10 mg/kg, i.p.), a 5-HT reuptake inhibitor, and 8-hydroxy-2-(di-n-propylamino)tetralin, a 5-HT(1A) receptor agonist, also suppressed the HTR induced by BZ-RAs.
Negative_regulation (suppressed) of HTR associated with agonist and fluoxetine
10) Confidence 0.17 Published 2001 Journal Pharmacology Section Abstract Doc Link 11287817 Disease Relevance 0 Pain Relevance 0.31
The HTR induced by BZ-RAs was suppressed by pretreatment with ketanserine (1 mg/kg, i.p.), a selective 5-HT(2) receptor antagonist.
Negative_regulation (suppressed) of HTR associated with antagonist
11) Confidence 0.17 Published 2001 Journal Pharmacology Section Abstract Doc Link 11287817 Disease Relevance 0 Pain Relevance 0.31
The 5HT2C receptor agonist mCPP (5.0 mg x kg(-1), I.P.) caused a drastic reduction in sodium appetite in HTR and ETR in depleted and deprived rats, respectively, after 120 min.
Negative_regulation (reduction) of HTR associated with agonist
12) Confidence 0.05 Published 2003 Journal Exp. Physiol. Section Abstract Doc Link 12621530 Disease Relevance 0 Pain Relevance 0.26
The presynaptic serotonin reuptake inhibitor fluoxetine (20.0 mg x kg(-1), I.P.) led to the inhibition of sodium appetite in HTR during the initial 30 min in depleted rats and for up to 60 min post-injection in deprived rats, while sodium appetite inhibition persisted for longer periods in ETR.
Negative_regulation (inhibition) of HTR associated with serotonin and fluoxetine
13) Confidence 0.05 Published 2003 Journal Exp. Physiol. Section Abstract Doc Link 12621530 Disease Relevance 0 Pain Relevance 0.27

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