INT50340

Context Info Confidence 0.57 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.54 Pain Relevance 0.20

Anatomy Link Frequency keratinocytes 1 Ifna (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 98.04 Inflammation 3 96.84 cINOD 1 50.20 Pain 6 5.00 headache 6 5.00 cva 3 5.00 Analgesic 2 5.00 tolerance 2 5.00 Arthritis 2 5.00 Potency 2 5.00

Disease Link Frequency Relevance Heat Infection 78 99.24 INFLAMMATION 4 96.84 Togavirus Infection 40 96.64 Cancer 3 94.48 Necrosis 1 94.00 Fever 58 83.88 Hypersensitivity 2 80.68 Alopecia Areata 31 75.48 Influenza Virus Infection 3 75.00 Malaria 19 74.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A‘cytokine inhibitor’ theory has been planned, which proposes a possible interference of contact allergens with the pre-existing proinflammatory cytokines and also their continued production by follicular keratinocytes.[2] The other events noted are a decrease in the raised interferon ?

Negative_regulation (decrease) of interferon in keratinocytes associated with cytokine

1) Confidence 0.57 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002409 Disease Relevance 0.49 Pain Relevance 0.10

These data suggest that FA and IFA are novel and potent inhibitors of murine IL-8 production and might act as one of the main components of anti-inflammatory rhizoma of Cimicifuga species.

Negative_regulation (inhibitors) of IFA associated with inflammation

2) Confidence 0.45 Published 1995 Journal Planta Med. Section Abstract Doc Link 7617763 Disease Relevance 0.38 Pain Relevance 0.10

Despite the fact that IFA can be more affordable for routine detection of CHIKV infection as compared to RT-PCR, nevertheless, IFA can be limited by the sensitivity of the assay in the detection of CHIKV infection.

Negative_regulation (limited) of IFA associated with infection

3) Confidence 0.07 Published 2010 Journal Virol J Section Body Doc Link PMC2827404 Disease Relevance 0.42 Pain Relevance 0

As shown in Figure 2, the detection limit of IFA is limited to 102 PFU/ml of infectious virus titer.

Negative_regulation (limit) of IFA

4) Confidence 0.07 Published 2010 Journal Virol J Section Body Doc Link PMC2827404 Disease Relevance 0.35 Pain Relevance 0

Based on the 2,662 cases with definitive DENV diagnosis (IFA or RT-PCR confirmation in the acute sample), 847 (32.0%) also had IgM reactive to YFV antigen in the acute or convalescent sample.

Negative_regulation (definitive) of IFA

5) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919378 Disease Relevance 0.90 Pain Relevance 0

General Comments

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