INT50533

Context Info Confidence 0.11 First Reported 1994 Last Reported 1994 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0.10

lyase activity (CA3) aging (ADRB3) carbohydrate metabolic process (ADRB3) cytoplasm (CA3) signal transducer activity (ADRB3) generation of precursor metabolites and energy (ADRB3)

Anatomy Link Frequency CAR 3 ADRB3 (Homo sapiens) CA3 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 1 98.72

Disease Link Frequency Relevance Heat Cancer 2 99.22 Pancreatitis 1 98.72 Pancreatic Cancer 5 97.74

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Surgery confirmed pancreatic cancer in 3 out of the 5 patients (chronic pancreatitis and periampullary cancer in one each); in all these 3 patients immunostaining with the MoAb AR-3 demonstrated the presence of the CAR-3 antigen (with a cytoplasmic and endoluminal/secretory pattern of distribution).

AR-3 Binding (immunostaining) of in CAR Positive_regulation (demonstrated) of Gene_expression (presence) of CAR-3 in CAR associated with cancer, pancreatic cancer and chronic pancreatitis

1) Confidence 0.11 Published 1994 Journal J Nucl Biol Med Section Abstract Doc Link 7632759 Disease Relevance 0.61 Pain Relevance 0.10

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