INT50572

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 0.51
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akr1d1) oxidoreductase activity (Akr1d1) cytoplasm (Akr1d1)
Anatomy Link Frequency
neurons 3
neuronal 1
striatum 1
whiskers 1
Akr1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 472 100.00 Very High Very High Very High
gABA 48 99.98 Very High Very High Very High
dopamine receptor 30 99.98 Very High Very High Very High
antagonist 49 99.22 Very High Very High Very High
agonist 95 98.68 Very High Very High Very High
Glutamate 24 98.00 Very High Very High Very High
Enkephalin 14 93.92 High High
substance P 10 92.20 High High
Serotonin 16 90.64 High High
Glutamate receptor 3 89.52 High High
Disease Link Frequency Relevance Heat
Camurati-engelmann Disease 1 94.56 High High
Increased Venous Pressure Under Development 120 81.92 Quite High
Peripheral Arterial Disease 21 78.88 Quite High
Depression 12 75.00 Quite High
Aids-related Complex 12 31.44 Quite Low
Body Weight 1 14.80 Low Low
Anaerobic Bacterial Infections 8 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study was undertaken in order to analyze in detail the expression of the D1 and D2 receptor genes in the efferent striatal populations, with special reference to the various striatal areas, and to yield insights into the question about D1 and D2 mRNA localization in the striatum.
Localization (localization) of D1 in striatum
1) Confidence 0.59 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.42
In contrast, on the basis of several in vivo and in vitro studies, other authors have suggested the existence of an extensive colocalization of D1 and D2 in the same striatal neurons.
Localization (colocalization) of D1 in neurons
2) Confidence 0.59 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.40
D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum.
Localization (segregation) of D1 in neuronal associated with dopamine receptor
3) Confidence 0.55 Published 1995 Journal J. Comp. Neurol. Section Title Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.30
Similar broad peaks at 50–180 Hz were observed for D1, D2, and D3 whiskers moving across a variety of surfaces (see below).
Localization (observed) of D1 in whiskers
4) Confidence 0.33 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.06 Pain Relevance 0
The pharmacological characteristics and anatomical distribution of dopamine D1- and D2-like receptors sites were investigated using combined pharmacological techniques and immunofluorescent microscopy. 3.
Localization (distribution) of D1 associated with dopamine
5) Confidence 0.31 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15008964 Disease Relevance 0 Pain Relevance 0.12
In conclusion, our results suggest that (i) dopamine agonists can exert an excitatory influence on depolarization-induced GABA release within neostriatum via D1 receptors and an inhibitory influence via D2 receptors; (ii) under the conditions of these experiments, endogenous dopamine fails to act on D1 sites but does exert an inhibitory influence via D2 sites; and (iii) there is an interaction between D1 and D2 receptors such that the actions of dopamine mediated via D1 sites are inhibited as a result of the concomitant actions exerted via D2 sites.
Localization (release) of D1 associated with gaba, dopamine and agonist
6) Confidence 0.11 Published 1997 Journal Neuroscience Section Abstract Doc Link 9472401 Disease Relevance 0 Pain Relevance 0.80
It was tested whether the antagonist effects were due to dopamine receptor blockade or increased tone on D1/D2 receptors.
Localization (blockade) of D1 associated with dopamine receptor and antagonist
7) Confidence 0.08 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12390525 Disease Relevance 0 Pain Relevance 0.88
The data suggest that CB1 receptors are co-localized with D1 or D2 receptors on the same population of striatal membranes and can interact at the level of G-protein/adenylyl cyclase signal transduction.
Localization (co-localized) of D1
8) Confidence 0.04 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11378162 Disease Relevance 0 Pain Relevance 0.38
To block the actions of dopamine released by hypothalamic neurons, D1 and D2 dopamine receptor antagonists were used.
Localization (released) of D1 in neurons associated with dopamine, antagonist and dopamine receptor
9) Confidence 0.04 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8985891 Disease Relevance 0.07 Pain Relevance 1.29
Many connections showed both D1 and D2 modulation, consistent with a significant functional colocalization of D1 and D2-like receptors at presynaptic sites.
Localization (colocalization) of D1
10) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1538613 Disease Relevance 0.20 Pain Relevance 0.49
Confocal immunocytochemical studies with D1 and D2 receptor-selective antisera reported near complete D1/D2 colocalization on MSNs identified by DARPP-32 expression [31].
Localization (colocalization) of D1
11) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.22
While single-cell RT-PCR studies confirmed the lack of D1/D2 receptor colocalization in MSNs, they also showed about a 50% colocalization of D1-like and D2-like receptors [23].
Localization (colocalization) of D1
12) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.23
While single-cell RT-PCR studies confirmed the lack of D1/D2 receptor colocalization in MSNs, they also showed about a 50% colocalization of D1-like and D2-like receptors [23].
Localization (colocalization) of D1
13) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.28
Responses of each neuron to stimulation of three whiskers D1, D2 and D3 were recorded and stored on hard disk.


Localization (stimulation) of D1 in neuron
14) Confidence 0.01 Published 2006 Journal Neuroscience Section Body Doc Link PMC2860223 Disease Relevance 0.17 Pain Relevance 0.06

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