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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2010
Negated 9
Speculated 7
Reported most in Abstract
Documents 45
Total Number 52
Disease Relevance 30.99
Pain Relevance 13.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
macrophages 10
colon 4
microglial cells 4
be cell 2
cartilage 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 265 100.00 Very High Very High Very High
Perioperative pain 1 99.84 Very High Very High Very High
aspirin 36 99.48 Very High Very High Very High
rheumatoid arthritis 90 99.32 Very High Very High Very High
Osteoarthritis 240 99.20 Very High Very High Very High
qutenza 10 98.64 Very High Very High Very High
COX2 33 98.32 Very High Very High Very High
cOX1 11 98.32 Very High Very High Very High
Inflammation 495 97.28 Very High Very High Very High
COX-2 inhibitor 94 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 94 100.00 Very High Very High Very High
Colon Cancer 59 100.00 Very High Very High Very High
Post Operative Pain 1 99.84 Very High Very High Very High
Apoptosis 266 99.76 Very High Very High Very High
Death 52 99.60 Very High Very High Very High
Prostate Cancer 11 99.60 Very High Very High Very High
Cancer 507 99.44 Very High Very High Very High
Rheumatoid Arthritis 91 99.32 Very High Very High Very High
INFLAMMATION 625 99.30 Very High Very High Very High
Osteoarthritis 243 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that redox status-dependent regulation of COX expression may mediate apoptosis induced by Cap in human neuroblastoma cells.
Regulation (regulation) of Gene_expression (expression) of COX associated with neuroblastoma, qutenza and apoptosis
1) Confidence 0.54 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086397 Disease Relevance 0.90 Pain Relevance 0.78
The effect of the mitogens on COX enzyme expression was also evaluated.
Regulation (effect) of Gene_expression (expression) of COX enzyme
2) Confidence 0.46 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10874020 Disease Relevance 0.90 Pain Relevance 0.18
In the present work, we characterize the protective effect of the indomethacin on the neurotoxicity elicited by amyloid-beta protein (A beta, fragments 25-35 and 1-42) alone or in combination with AA added exogenously as well as its effects on COX-2 expression.
Regulation (effects) of Gene_expression (expression) of COX associated with drug induced neurotoxicity and alzheimer's dementia
3) Confidence 0.43 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16169124 Disease Relevance 1.03 Pain Relevance 0.44
A brief review of the molecular biology, pharmacology, and primary actions of COX-2 outside of the nervous system provides a context for understanding potential neurobiological roles for COX-2 and prostanoid production.
Regulation (roles) of Gene_expression (production) of COX in nervous system
4) Confidence 0.41 Published 1999 Journal Crit Rev Neurobiol Section Abstract Doc Link 10223523 Disease Relevance 0.46 Pain Relevance 0.15
We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microglial cells in vitro.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of COX in microglial cells associated with disease
5) Confidence 0.30 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.70 Pain Relevance 0.10
The regulation of COX expression in neuronal cells is only partly understood and has been mainly linked to synaptic activity.
Regulation (regulation) of Gene_expression (expression) of COX in neuronal
6) Confidence 0.29 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.54 Pain Relevance 0.14
We provide comprehensive knowledge on the differential regulation of expression and catalysis of cyclooxygenase (COX)-1 and COX-2 in health and disease which represents an essential requirement to read out the clinical consequences of selective and nonselective inhibition of COX-isozymes in humans.
Regulation (regulation) of Gene_expression (expression) of COX associated with disease
7) Confidence 0.27 Published 2007 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 17164136 Disease Relevance 0.24 Pain Relevance 0.11
Aceclofenac and 4'-hydroxyaceclofenac are the major compounds in human blood after the administration of aceclofenac, but they had no inhibitory effects on cyclooxygenase (COX) activity or COX expression in the rheumatoid synovial cells.
Neg (no) Regulation (effects) of Gene_expression (expression) of COX in synovial cells
8) Confidence 0.26 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215639 Disease Relevance 0.27 Pain Relevance 0.25
Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells.
Neg (without) Regulation (affecting) of Gene_expression (expression) of COX associated with prostate cancer and cox1
9) Confidence 0.26 Published 2005 Journal Int. J. Cancer Section Title Doc Link 15455372 Disease Relevance 0.63 Pain Relevance 0.18
Furthermore, COX-2 mRNA levels induced by LPS were transient (peak 3-4 h), suggesting that PGE2 was unable to regulate COX-2 expression in an autocrine manner.
Neg (unable) Regulation (regulate) of Gene_expression (expression) of COX
10) Confidence 0.26 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.15 Pain Relevance 0.37
These data suggest that the enhanced expression of the COX-2 gene in colon cancer tissues may contribute to the enhanced synthesis of prostaglandin E2 by the colon cancer tissues.
Spec (may) Regulation (contribute) of Gene_expression (expression) of COX in colon associated with colon cancer
11) Confidence 0.23 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7641194 Disease Relevance 1.16 Pain Relevance 0.25
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to modulate cyclooxygenase (COX)-2 expression, but the mechanisms involved are controversial and may be cell specific.
Regulation (modulate) of Gene_expression (expression) of COX in be cell associated with inflammation and cinod
12) Confidence 0.22 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.17 Pain Relevance 0.32
We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microglial cells in vitro.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of COX in microglial cells associated with disease
13) Confidence 0.22 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.70 Pain Relevance 0.10
Our data suggest that IL-1beta-induced COX-2 expression in SK-N-SH cells is regulated by different mechanisms, presumably involving mRNA transcription and mRNA stability.
Regulation (regulated) of Gene_expression (expression) of COX in SK-N-SH
14) Confidence 0.21 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.44 Pain Relevance 0.11
In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 (PGE2) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.
Regulation (effects) of Gene_expression (expression) of COX in PGE2 associated with perioperative pain
15) Confidence 0.19 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18165598 Disease Relevance 0.44 Pain Relevance 0.47
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Regulation (effect) of Gene_expression (production) of COX in macrophages associated with cinod
16) Confidence 0.19 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.40
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Regulation (effect) of Gene_expression (production) of COX in macrophages associated with cinod
17) Confidence 0.19 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.40
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Regulation (effect) of Gene_expression (expression) of COX in macrophages associated with cinod
18) Confidence 0.19 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.39
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Regulation (effect) of Gene_expression (expression) of COX in macrophages associated with cinod
19) Confidence 0.19 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.39
Here, we show that EGCG inhibits COX-2 without affecting COX-1 expression at both the mRNA and protein levels, in androgen-sensitive LNCaP and androgen-insensitive PC-3 human prostate carcinoma cells.
Neg (without) Regulation (affecting) of Gene_expression (expression) of COX in PC-3 associated with prostate cancer
20) Confidence 0.19 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15455372 Disease Relevance 0.66 Pain Relevance 0.07

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