INT5069

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 69
Total Number 69
Disease Relevance 22.54
Pain Relevance 31.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfs) Golgi apparatus (Mthfs) ligase activity (Mthfs)
cytoplasm (Mthfs) plasma membrane (Mthfs) molecular_function (Mthfs)
Anatomy Link Frequency
platelet 3
spinal 2
smooth muscle 1
brain 1
granulation 1
Mthfs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
acular 5 100.00 Very High Very High Very High
cINOD 77 99.98 Very High Very High Very High
bradykinin 20 99.90 Very High Very High Very High
antagonist 19 99.86 Very High Very High Very High
aspirin 59 99.84 Very High Very High Very High
narcan 9 99.84 Very High Very High Very High
diclofenac 39 99.80 Very High Very High Very High
Opioid 4 99.80 Very High Very High Very High
Potency 10 99.66 Very High Very High Very High
Paracetamol 7 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 99.92 Very High Very High Very High
INFLAMMATION 131 99.86 Very High Very High Very High
Pain 36 99.54 Very High Very High Very High
Pressure And Volume Under Development 41 99.52 Very High Very High Very High
Hyperalgesia 76 99.38 Very High Very High Very High
Sprains And Strains 39 99.04 Very High Very High Very High
Increased Venous Pressure Under Development 5 99.04 Very High Very High Very High
Toxicity 11 98.98 Very High Very High Very High
Nociception 9 98.52 Very High Very High Very High
Inflammatory Pain 8 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of cyclo-oxygenase and or its substrate(s) on the neuroactivity of evening primrose oil was investigated on the basis that a blockade of cyclo-oxygenase activity using aspirin would inhibit neuroactivity of primrose oil if this effect was mediated by prostanoids.
Negative_regulation (blockade) of cyclo-oxygenase associated with aspirin
1) Confidence 0.57 Published 1996 Journal J Lipid Mediat Cell Signal Section Abstract Doc Link 8925193 Disease Relevance 0.09 Pain Relevance 0.21
The results support previous findings that inhibition of cyclo-oxygenase in rat mesenteric blood vessels leads to a loss of response to noradrenaline.
Negative_regulation (inhibition) of cyclo-oxygenase in blood vessels associated with noradrenaline
2) Confidence 0.57 Published 1986 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2877068 Disease Relevance 0.14 Pain Relevance 0.86
As far as acute gastric toxicity is concerned, neither the potency of a drug as an inhibitor of cyclo-oxygenase nor the fraction of unchanged or conjugated agent excreted in bile appeared to be relevant.
Negative_regulation (inhibitor) of cyclo-oxygenase in bile associated with toxicity, bile and potency
3) Confidence 0.57 Published 1990 Journal Arch. Toxicol. Section Abstract Doc Link 2115324 Disease Relevance 0.49 Pain Relevance 0.43
Indomethacin is more effective in attenuating the effect of arachidonic acid, possibly due to actions other than inhibition of cyclo-oxygenase.


Negative_regulation (inhibition) of cyclo-oxygenase
4) Confidence 0.57 Published 1994 Journal J. Hypertens. Section Body Doc Link 7814848 Disease Relevance 0 Pain Relevance 0
The R-enantiomer, which does not inhibit cyclo-oxygenase in vitro, was almost as effective as the S-enantiomer, which does inhibit prostaglandin synthesis in different models of pain and nociception.
Negative_regulation (inhibit) of cyclo-oxygenase associated with nociception and pain
5) Confidence 0.57 Published 1992 Journal Drugs Section Abstract Doc Link 1284562 Disease Relevance 0.26 Pain Relevance 0.80
Indomethacin, inhibitor of cyclo-oxygenase was used as reference drug.
Negative_regulation (inhibitor) of cyclo-oxygenase
6) Confidence 0.57 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17913418 Disease Relevance 0.71 Pain Relevance 0.19
The R-enantiomer, which is practically devoid of peripheral cyclo-oxygenase inhibitory activity in vitro, showed comparable analgesic potency to the S-enantiomer, which does inhibit cyclo-oxygenase activity, in experimental models of nociception.
Negative_regulation (inhibit) of cyclo-oxygenase associated with nociception, analgesic and potency
7) Confidence 0.57 Published 1994 Journal Drugs Section Abstract Doc Link 7525182 Disease Relevance 0.23 Pain Relevance 0.98
Our results indicate that the effect of morphine on mesolimbic dopamine cells is potentiated by blocking cyclo-oxygenase activity and suggest that the modulation of cyclo-oxygenase pathway in dopamine cells might be involved in the cellular mechanisms of the rewarding actions of morphine.
Negative_regulation (blocking) of cyclo-oxygenase associated with dopamine and morphine
8) Confidence 0.57 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633170 Disease Relevance 0 Pain Relevance 0.76
Indomethacin (10 mg kg(-1), i.p.), a non-selective cyclo-oxygenase inhibitor, inhibited only the propofol-evoked response and this recovered with arterial PGE2 (5 microg).
Negative_regulation (inhibitor) of cyclo-oxygenase
9) Confidence 0.57 Published 2005 Journal Br J Anaesth Section Body Doc Link 15994849 Disease Relevance 0 Pain Relevance 0
These results suggest that inhibition of cyclo-oxygenase by aspirin does not play any important roles for the prevention of the vascular permeability increment and the granulation in the inflamed tissue.
Negative_regulation (inhibition) of cyclo-oxygenase in granulation associated with aspirin
10) Confidence 0.56 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 3921440 Disease Relevance 0.91 Pain Relevance 0.90
Most NSAID inhibit prostaglandin cyclo-oxygenase activity, which results in a prostaglandin deficiency at the tissue level.
Negative_regulation (inhibit) of cyclo-oxygenase associated with cinod
11) Confidence 0.54 Published 1988 Journal Toxicol Pathol Section Abstract Doc Link 3142029 Disease Relevance 0.44 Pain Relevance 0.46
Interaction with this putative supplementary site is necessary but not sufficient for the efficacy of these drugs on cyclo-oxygenase inhibitors.
Negative_regulation (inhibitors) of cyclo-oxygenase
12) Confidence 0.53 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6799004 Disease Relevance 0.14 Pain Relevance 0.27
Therefore, non-steroidal anti-inflammatory drugs, via cyclo-oxygenase inhibition, may have multiple actions in control of spinal sensory mechanisms.
Negative_regulation (inhibition) of cyclo-oxygenase in spinal associated with inflammation and cinod
13) Confidence 0.47 Published 1999 Journal Neuroscience Section Abstract Doc Link 10473275 Disease Relevance 0.10 Pain Relevance 0.43
Non-steroidal anti-inflammatory drugs inhibit platelet cyclo-oxygenase activity.
Negative_regulation (inhibit) of platelet cyclo-oxygenase in platelet associated with inflammation and cinod
14) Confidence 0.46 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6799004 Disease Relevance 0.17 Pain Relevance 0.25
We examined the in vivo effects of the anti-inflammatory agent ketorolac, a cyclo-oxygenase inhibitor that blocks prostaglandin synthesis, on hepatic amino acid transport activity in endotoxin-treated rats.
Negative_regulation (inhibitor) of cyclo-oxygenase associated with inflammation and acular
15) Confidence 0.43 Published 1995 Journal JPEN J Parenter Enteral Nutr Section Abstract Doc Link 7658609 Disease Relevance 0.19 Pain Relevance 0.15
Cyclo-oxygenase blockade abrogates the endotoxin-induced increase in Na(+)-dependent hepatic amino acid transport.
Negative_regulation (blockade) of Cyclo-oxygenase associated with acular
16) Confidence 0.43 Published 1995 Journal JPEN J Parenter Enteral Nutr Section Title Doc Link 7658609 Disease Relevance 0.18 Pain Relevance 0.23
The rank order of potency of the NSAIDs for inhibition of responses to noradrenaline was: meclofenamate greater than flufenamate = diclofenac greater than indomethacin greater than fenbufen greater than phenylbutazone greater than ibuprofen greater than ketoprofen greater than naproxen greater than paracetamol (included as an inhibitor of cyclo-oxygenase).
Negative_regulation (inhibitor) of cyclo-oxygenase associated with paracetamol, noradrenaline, cinod, diclofenac and potency
17) Confidence 0.42 Published 1986 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2877068 Disease Relevance 0.16 Pain Relevance 0.87
Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors.
Negative_regulation (inhibitors) of cyclo-oxygenase associated with inflammation
18) Confidence 0.41 Published 2005 Journal Inflammopharmacology Section Title Doc Link 16280097 Disease Relevance 0.60 Pain Relevance 0.51
The possible roles of p-phenetidine as the active metabolite of phenacetin for cyclo-oxygenase inhibition in brain and of phenacetin as an organ pro-drug are discussed.
Negative_regulation (inhibition) of cyclo-oxygenase in brain
19) Confidence 0.41 Published 1982 Journal Life Sci. Section Abstract Doc Link 6808277 Disease Relevance 0.16 Pain Relevance 0.46
Two cyclo-oxygenase inhibitors, indomethacin and nimesulide, have been shown to potentiate morphine-induced stimulation of meso-accumbens dopamine neurons.
Negative_regulation (inhibitors) of cyclo-oxygenase in dopamine neurons associated with dopamine and morphine
20) Confidence 0.41 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11011036 Disease Relevance 0.07 Pain Relevance 0.18

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