INT50705

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.65
Pain Relevance 6.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
neurons 1
dorsal root ganglion 1
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 8 100.00 Very High Very High Very High
qutenza 107 99.92 Very High Very High Very High
Kinase C 5 99.84 Very High Very High Very High
antagonist 18 99.56 Very High Very High Very High
Analgesic 33 99.20 Very High Very High Very High
dorsal root ganglion 32 99.04 Very High Very High Very High
Glutamate 2 98.72 Very High Very High Very High
Pain management 4 98.32 Very High Very High Very High
Sciatic nerve 92 98.08 Very High Very High Very High
analgesia 45 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 36 98.60 Very High Very High Very High
Pain 100 98.32 Very High Very High Very High
Hyperalgesia 99 96.08 Very High Very High Very High
INFLAMMATION 228 95.56 Very High Very High Very High
Death 4 75.76 Quite High
Neurogenic Inflammation 25 63.64 Quite High
Pressure And Volume Under Development 17 60.32 Quite High
Nociception 65 58.52 Quite High
Hypersensitivity 11 49.76 Quite Low
Neuropathic Pain 11 41.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data imply that although resiniferatoxin-induced translocation of protein kinase C in dorsal root ganglion neurones was mainly indirect, it also caused direct activation of a protein kinase C-like kinase in these cells.
Localization (translocation) of resiniferatoxin in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and kinase c
1) Confidence 0.44 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.18 Pain Relevance 0.73
Repeated application of RTX did not affect excitatory transmission.
Localization (application) of RTX
2) Confidence 0.40 Published 2009 Journal Neuroscience Section Abstract Doc Link 19778582 Disease Relevance 0 Pain Relevance 0.95
RTX was solubilized in 150 ?
Localization (solubilized) of RTX
3) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.13 Pain Relevance 0.07
As such, localized application of RTX has the potential for a range of uses in pain management, from acute post-operative care to treatment of regional pain disorders.


Localization (localized) of RTX associated with pain and pain management
4) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.95 Pain Relevance 0.87
As such, localized application of RTX has the potential for a range of uses in pain management, from acute post-operative care to treatment of regional pain disorders.


Localization (localized) of RTX associated with pain and pain management
5) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.95 Pain Relevance 0.87
Perineural application of RTX (250 ng, 50 ?
Localization (application) of RTX
6) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.94 Pain Relevance 0.83
We found that for perineural application of RTX there was a steep dose response relationship occurring between 62.5 and 125 ng, with doses ?
Localization (application) of RTX
7) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.64 Pain Relevance 0.61
Its preservation in RTX-treated animals is consistent with our data showing preservation of behavioral measures of mechanosensitivity, and together these results further confirm the specificity of RTX action.


Localization (preservation) of RTX-treated
8) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.36 Pain Relevance 0.30
Six days after acute exposure to CAP or RTX, SP release and SP expression of cultured rat DRG neurons decreased significantly in both CAP- and RTX-treated cultures as compared with controls.
Localization (release) of RTX in neurons associated with dorsal root ganglion, qutenza and substance p
9) Confidence 0.08 Published 2010 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 20383340 Disease Relevance 0.49 Pain Relevance 1.31

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