INT50776

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Context Info
Confidence 0.01
First Reported 1995
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 19 100.00 Very High Very High Very High
agonist 17 100.00 Very High Very High Very High
addiction 2 92.92 High High
tolerance 2 92.36 High High
opiate 2 91.96 High High
Kinase C 3 75.00 Quite High
Opioid 2 41.40 Quite Low
Analgesic 1 25.00 Low Low
Enkephalin 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results represent the identification of the GRK phosphorylation site on an opioid receptor for the first time and demonstrate that GRK is the prominent kinase responsible for agonist-induced opioid receptor phosphorylation in vivo.
Regulation (responsible) of Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor
1) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.51
In this study, the mouse delta-opioid receptor (delta OR) was used in a model system to investigate the role of opioid receptor phosphorylation in receptor desensitization.
Spec (investigate) Regulation (role) of Spec (investigate) Phosphorylation (phosphorylation) of opioid receptor associated with opioid receptor
2) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.79

General Comments

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