INT50781

Context Info Confidence 0.12 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.55 Pain Relevance 1.64

endoplasmic reticulum (Map3k5) kinase activity (Map3k5) response to stress (Map3k5) cytoplasm (Map3k5)

Map3k5 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 14 99.78 Kinase C 6 93.40 Dopamine 20 86.80 opioid receptor 10 75.00 addiction 2 59.76 tolerance 2 59.20 opiate 4 58.80 Enkephalin 2 25.00 Analgesic 2 25.00 Inflammation 2 10.00

Disease Link Frequency Relevance Heat Stress 3 89.28 Parkinson's Disease 18 78.32 Apoptosis 6 67.08 Toxicity 2 62.00 Neurodegenerative Disease 1 53.20 Aging 3 50.64 Targeted Disruption 10 5.00 Pain 1 5.00 Wound Infection 1 5.00 Disease 1 5.00

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sevoflurane exposure also induced phosphorylation of apoptosis signal-regulating kinase-1 (ASK1), MAP kinase kinases 3 and 6 (MKK3/MKK6), and ATF-2.

Phosphorylation (phosphorylation) of apoptosis signal-regulating kinase-1

1) Confidence 0.12 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349187 Disease Relevance 0.07 Pain Relevance 0

Whereas overexpression of a dominant negative mutant (K220R) of beta-adrenergic receptor kinase-1 (beta ARK1) in 293 cells significantly reduced agonist-dependent phosphorylation of the delta OR, overexpression of beta ARK1 or G protein-coupled receptor kinase-5 significantly enhanced this phosphorylation.

Phosphorylation (phosphorylation) of kinase-5 associated with agonist

2) Confidence 0.08 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.73

Whereas overexpression of a dominant negative mutant (K220R) of beta-adrenergic receptor kinase-1 (beta ARK1) in 293 cells significantly reduced agonist-dependent phosphorylation of the delta OR, overexpression of beta ARK1 or G protein-coupled receptor kinase-5 significantly enhanced this phosphorylation.

Phosphorylation (phosphorylation) of kinase-5 associated with agonist

3) Confidence 0.08 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.75

Importantly, Ser(P)-129 is not dephosphorylated by PP2A (72), a finding that we verified (Fig. 7B). a-Syn can be phosphorylated by at least three kinases, including casein kinase 2 (72, 96–99), G-protein-coupled receptor kinase 5 (100), and Polo-like kinases, especially PLK2, which exclusively phosphorylates Ser-129 (101).

Phosphorylation (phosphorylated) of kinase 5

4) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.48 Pain Relevance 0.15

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