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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 21.43
Pain Relevance 8.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgis) extracellular space (Ptgis) endoplasmic reticulum (Ptgis)
Anatomy Link Frequency
platelet 4
endothelial cells 3
plasma 2
smooth muscle 1
vascular endothelium 1
Ptgis (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 22 99.92 Very High Very High Very High
aspirin 58 99.84 Very High Very High Very High
Angina 40 99.80 Very High Very High Very High
depression 12 99.64 Very High Very High Very High
Inflammation 120 98.92 Very High Very High Very High
COX-2 inhibitor 45 98.74 Very High Very High Very High
ischemia 13 97.92 Very High Very High Very High
cINOD 162 95.88 Very High Very High Very High
Pain 3 95.44 Very High Very High Very High
iatrogenic 3 93.36 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 34 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 33 99.68 Very High Very High Very High
Depression 12 99.64 Very High Very High Very High
Thrombosis 5 99.56 Very High Very High Very High
Pre-eclampsia 4 99.56 Very High Very High Very High
Osteoid Osteoma 8 99.40 Very High Very High Very High
Osteogenic Sarcomas 3 99.40 Very High Very High Very High
Atherosclerosis 23 99.30 Very High Very High Very High
Adhesions 35 99.20 Very High Very High Very High
INFLAMMATION 169 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostacyclin is found in all body tissues and body fluids, and is the major metabolite of arachidonic acid in the vasculature.
Gene_expression (found) of Prostacyclin in body
1) Confidence 0.50 Published 1999 Journal Heart Dis Section Abstract Doc Link 11720602 Disease Relevance 0.28 Pain Relevance 0.05
This condition is associated with decreased prostacyclin synthesis.
Gene_expression (synthesis) of prostacyclin
2) Confidence 0.46 Published 1992 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 1285701 Disease Relevance 0.83 Pain Relevance 0.18
Much evidence has implied a deficient production of the antiaggregatory and vasodilator agent prostacyclin (PGI2) in preeclampsia and some other chronic fetoplacental insufficiency syndromes.
Gene_expression (production) of prostacyclin associated with syndrome and pre-eclampsia
3) Confidence 0.45 Published 1984 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6367477 Disease Relevance 0.27 Pain Relevance 0.12
In nine patients with osteoid osteoma, prostaglandin E2 (PGE2) and prostacyclin (PGI2) synthesis in explants from the nidus incubated in vitro yielded 947.3 +/- 482.6 (mean +/- SD) and 340.2 +/- 178.1 pg/mg of wet tissue respectively, values 32 and 49 times higher than in fragments of normal bone.
Gene_expression (synthesis) of prostacyclin associated with osteoid osteoma
4) Confidence 0.45 Published 1991 Journal Eicosanoids Section Abstract Doc Link 1772689 Disease Relevance 0.54 Pain Relevance 0.19
Increased prostacyclin biosynthesis in patients with osteoid osteoma.
Gene_expression (biosynthesis) of prostacyclin associated with osteoid osteoma
5) Confidence 0.45 Published 1991 Journal Eicosanoids Section Title Doc Link 1772689 Disease Relevance 0.62 Pain Relevance 0.19
with selective pulmonary PGI2 synthase (PGIS) overexpression
Gene_expression (overexpression) of PGIS
6) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.72 Pain Relevance 0.07
prostacyclin analogs and PPAR?
Gene_expression (analogs) of prostacyclin
7) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.49 Pain Relevance 0
overexpressing PGIS were crossed with mice deficient in IP (A.
Gene_expression (overexpressing) of PGIS
8) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.57 Pain Relevance 0.03
prostacyclin), produced through the cyclooxygenase pathway via prostacyclin
Gene_expression (produced) of prostacyclin
9) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.68 Pain Relevance 0.08
expression of COX-2 and PGI synthase (PGIS) in the human osteosarcoma cell
Gene_expression (expression) of PGIS associated with osteogenic sarcomas
10) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.26 Pain Relevance 0.23
the ectopic expression of COX-2 and PGIS in HEK293 cells results in a dramatic
Gene_expression (expression) of PGIS
11) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.21 Pain Relevance 0.06
ligand, formed by expressing PGIS in
Gene_expression (expressing) of PGIS
12) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.72 Pain Relevance 0.03
Estrogen increases expression of COX-2 and production of prostacyclin I2, effects that have been proposed to underlie its apparent cardioprotective effects in animal models [28].
Gene_expression (production) of prostacyclin I2
13) Confidence 0.17 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.28 Pain Relevance 0.30
Prostacyclin (prostaglandin 12, PGI2), which is synthesized by the vascular endothelium, is a potent vasodilator, inhibits the aggregation of platelets in vitro and has cytoprotective effect on gastrointestinal mucosa.
Gene_expression (synthesized) of Prostacyclin in platelets
14) Confidence 0.16 Published 2009 Journal Coll Antropol Section Abstract Doc Link 20120521 Disease Relevance 0.13 Pain Relevance 0.54
COXs synthesize prostacyclin I2 and thromboxane A2 from arachadonic acid.
Gene_expression (synthesize) of prostacyclin I2
15) Confidence 0.15 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.37 Pain Relevance 0.16
Prostacyclin I2, predominantly a product of COX-2, is a vasodilator that inhibits platelet aggregation and smooth muscle proliferation, effects that might be expected to reduce acute coronary syndromes and stroke.
Gene_expression (product) of Prostacyclin I2 in smooth muscle associated with acute coronary syndrome and stroke
16) Confidence 0.15 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.39 Pain Relevance 0.21
Prostacyclin production was estimated in 24 and thromboxane A2 production in six third-trimester pregnant women by measurement of excretion of urinary metabolites before and after ingestion of either 1000 mg of acetaminophen or placebo.
Gene_expression (production) of Prostacyclin
17) Confidence 0.11 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 8475962 Disease Relevance 0 Pain Relevance 0
Prostacyclin biosynthesis was markedly elevated in patients with acute myocardial infarction and correlated with plasma creatine kinase (r = 0.795; P less than 0.001).
Gene_expression (biosynthesis) of Prostacyclin in plasma associated with myocardial infarction
18) Confidence 0.11 Published 1986 Journal N. Engl. J. Med. Section Abstract Doc Link 3531859 Disease Relevance 1.02 Pain Relevance 0.56
CONCLUSION: Acetaminophen in typical oral doses results in reduced production of prostacyclin by endothelial cells in culture and in a reduction in prostacyclin, but not thromboxane, production in pregnant women.


Gene_expression (production) of prostacyclin in endothelial cells
19) Confidence 0.08 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 8475962 Disease Relevance 0 Pain Relevance 0
The increment in prostacyclin biosynthesis during such episodes may be a compensatory response of vascular endothelium that limits the degree or effects of platelet activation.
Gene_expression (biosynthesis) of prostacyclin in vascular endothelium
20) Confidence 0.08 Published 1986 Journal N. Engl. J. Med. Section Abstract Doc Link 3531859 Disease Relevance 1.17 Pain Relevance 0.80

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