INT5117

Context Info Confidence 0.59 First Reported 1985 Last Reported 2010 Negated 4 Speculated 2 Reported most in Abstract Documents 118 Total Number 120 Disease Relevance 52.33 Pain Relevance 29.96

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2) cell-cell signaling (IL2)

Anatomy Link Frequency T cell 53 lymphocytes 24 blood 12 natural killer cell 7 mononuclear cells 6 IL2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 1525 100.00 Inflammation 1080 100.00 aspirin 92 100.00 antagonist 182 99.98 agonist 112 99.98 Morphine 28 99.98 Intracerebroventricular 1 99.98 potassium channel 11 99.90 corticosteroid 131 99.84 narcan 17 99.84

Disease Link Frequency Relevance Heat INFLAMMATION 1192 100.00 Hyperplasia 66 100.00 Infection 224 99.92 Aging 432 99.76 Pruritus 33 99.60 Acquired Immune Deficiency Syndrome Or Hiv Infection 362 99.48 Cancer 480 99.28 Eczema 79 99.28 Pressure And Volume Under Development 74 99.28 Head & Neck Cancer 20 99.28

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Mutation

Event

Anatomy

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Disease term

There was some additive inhibition of IL-2 receptor expression at the higher concentrations of verapamil and cyclosporine that were tested.

Negative_regulation (inhibition) of Gene_expression (expression) of IL-2

1) Confidence 0.59 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.44 Pain Relevance 0.16

Production of IL-2 was suppressed by 0.1-100 microM of heroin, whereas exposure to methadone appeared to result in a generalized modulation, with suppression of IL-2 at most concentrations.

Negative_regulation (suppressed) of Gene_expression (Production) of IL-2 associated with methadone

2) Confidence 0.57 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7713351 Disease Relevance 0.12 Pain Relevance 0.45

Isolated compound inhibited the production of TNF-alpha and IL-2; further compound 5 showed significant analgesic activities in a dose dependant manner.

Negative_regulation (inhibited) of Gene_expression (production) of IL-2 associated with analgesic

3) Confidence 0.57 Published 2009 Journal Eur J Med Chem Section Abstract Doc Link 18243423 Disease Relevance 0.07 Pain Relevance 0.25

In addition, the production of IL-2 was inhibited by the opioid treatment, but this might not be the only mechanism of action.

Negative_regulation (inhibited) of Gene_expression (production) of IL-2 associated with opioid

4) Confidence 0.56 Published 2004 Journal Life Sci. Section Abstract Doc Link 15102522 Disease Relevance 0.08 Pain Relevance 0.52

Defective expression of IL-2 receptors on peripheral blood lymphocytes from patients with cluster headache.

Negative_regulation (Defective) of Gene_expression (expression) of IL-2 in lymphocytes associated with cluster headache

5) Confidence 0.55 Published 1990 Journal Headache Section Title Doc Link 2335478 Disease Relevance 0.35 Pain Relevance 0.35

In the 6 patients treated with MVP alone, depressed PHA reactivity was found pretherapy, which was augmented by indomethacin, but not by IL-2; this was associated with impaired production of IL-2.

Negative_regulation (impaired) of Gene_expression (production) of IL-2 associated with mitral valve prolapse

6) Confidence 0.50 Published 1987 Journal J Biol Response Mod Section Abstract Doc Link 3037033 Disease Relevance 0.75 Pain Relevance 0.07

In this regard, it is especially disappointing that IL-2 administration had no discernible effect, given the numerous studies, noted previously, that point to a defect in IL-2 production as one of the hallmarks of the immunodeficiency of chronic HIV infection.

Negative_regulation (defect) of Gene_expression (production) of IL-2 associated with acquired immune deficiency syndrome or hiv infection, infection and immunodeficiency

7) Confidence 0.48 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1783674 Disease Relevance 0.63 Pain Relevance 0.06

This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.

Negative_regulation (inhibition) of Gene_expression (production) of IL-2

8) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14

Routine flow cytometry (FACS) examination of cell surface markers ascertained that the numbers of IL-2 producing lymphocytes were comparable in all PBMC preparations.

Negative_regulation (numbers) of Gene_expression (producing) of IL-2 in lymphocytes

9) Confidence 0.43 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.03

This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.

Negative_regulation (responsiveness) of Gene_expression (production) of IL-2

10) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14

This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.

Negative_regulation (inhibition) of Gene_expression (production) of IL-2

11) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14

[Intracerebroventricular injection of interleukin-2 inhibits splenic sympathetic nerve activity].

Negative_regulation (inhibits) of Gene_expression (injection) of interleukin-2 in nerve associated with narcan and intracerebroventricular

12) Confidence 0.43 Published 1996 Journal Sheng Li Xue Bao Section Title Doc Link 9387781 Disease Relevance 0 Pain Relevance 0.34

Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone.

Negative_regulation (decreased) of Gene_expression (levels) of IL-2 associated with antagonist, narcan, opioid, infection and morphine

13) Confidence 0.40 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.38 Pain Relevance 1.00

This phenomenon led to an investigation of the phenotypic expression of PBL before and after IL-2 incubation, and of the IL-2 lymphocyte receptor.

Spec (investigation) Negative_regulation (investigation) of Gene_expression (expression) of IL-2 in lymphocyte

14) Confidence 0.40 Published 1990 Journal Headache Section Abstract Doc Link 2335478 Disease Relevance 0.32 Pain Relevance 0.32

The data support the hypothesis that cyclosporine may be an antagonist of calmodulin that selectively blocks early events in T lymphocyte activation leading to IL-2 synthesis, but does not inhibit the expression or function of the IL-2 receptor.

Negative_regulation (inhibit) of Gene_expression (expression) of IL-2 in T lymphocyte associated with antagonist

15) Confidence 0.40 Published 1986 Journal Transplantation Section Abstract Doc Link 3097893 Disease Relevance 0 Pain Relevance 0.12

Augmentation of IL-2 production by aspirin and/or TF5 was prevented by monocyte depletion of the PBL population.

Negative_regulation (prevented) of Gene_expression (production) of IL-2 in monocyte associated with aspirin

16) Confidence 0.40 Published 1985 Journal Immunopharmacology Section Abstract Doc Link 3926716 Disease Relevance 0.07 Pain Relevance 0.36

The synthetic peptide containing residues 43-49 of alpha-gliadin, the major protein component of gluten, has previously been shown to inhibit the production of lymphokine activities by mononuclear leukocytes.

Negative_regulation (inhibit) of Gene_expression (production) of lymphokine in leukocytes

17) Confidence 0.38 Published 1987 Journal Life Sci. Section Abstract Doc Link 3561149 Disease Relevance 0 Pain Relevance 0.11

Supporting this theory is the finding that ciclosporin A, an inhibitor of lymphokine production, reduces itch in atopic dermatitis.

Negative_regulation (inhibitor) of Gene_expression (production) of lymphokine associated with pruritus and eczema

18) Confidence 0.37 Published 1992 Journal Skin Pharmacol. Section Abstract Doc Link 1575979 Disease Relevance 1.69 Pain Relevance 0.44

In vitro tests included (a) phytohemagglutinin (PHA) responsiveness in the presence of indomethacin or interleukin-2 (IL-2), (b) natural killer cell (NK) function, and (c) PHA-induced IL-2 synthesis.

Negative_regulation (responsiveness) of Gene_expression (synthesis) of IL-2 in natural killer cell

19) Confidence 0.37 Published 1987 Journal J Biol Response Mod Section Abstract Doc Link 3037033 Disease Relevance 0.74 Pain Relevance 0.08

In vitro tests included (a) phytohemagglutinin (PHA) responsiveness in the presence of indomethacin or interleukin-2 (IL-2), (b) natural killer cell (NK) function, and (c) PHA-induced IL-2 synthesis.

Negative_regulation (responsiveness) of Gene_expression (synthesis) of IL-2 in natural killer cell

20) Confidence 0.37 Published 1987 Journal J Biol Response Mod Section Abstract Doc Link 3037033 Disease Relevance 0.74 Pain Relevance 0.08

General Comments

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