INT51242

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Context Info
Confidence 0.80
First Reported 1993
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.96
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
plasma membrane (Umod)
Anatomy Link Frequency
THP-1 1
proximal 1
bladder 1
Umod (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 87.12 High High
antagonist 1 73.36 Quite High
cytokine 10 68.44 Quite High
Inflammation 8 68.04 Quite High
chemokine 3 67.20 Quite High
interstitial cystitis 2 50.00 Quite Low
Inflammatory mediators 2 38.16 Quite Low
Inflammatory response 4 7.36 Low Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 2 98.32 Very High Very High Very High
Renal Disease 4 97.98 Very High Very High Very High
Shock 8 88.16 High High
INFLAMMATION 14 68.04 Quite High
Crystal Associated Disease 2 15.24 Low Low
Fever 6 10.16 Low Low
Fabry Disease 18 5.00 Very Low Very Low Very Low
Plasmodium Infection 17 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low
Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patients who were routinely found to have no signs of nephropathy showed no dysfunction of renal glomeruli and distal or proximal tubule as determined by the urinary excretion of albumins, Tamm-Horsfall protein and beta-2-microglobulins prior to the operation.
Spec (determined) Localization (excretion) of Tamm-Horsfall protein in proximal associated with renal disease
1) Confidence 0.80 Published 2003 Journal Wiad. Lek. Section Abstract Doc Link 15049201 Disease Relevance 0.25 Pain Relevance 0.07
MATERIALS AND METHODS: Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein.
Spec (analyzed) Localization (excretion) of Tamm-Horsfall protein in bladder
2) Confidence 0.61 Published 1996 Journal J. Urol. Section Body Doc Link 8709369 Disease Relevance 0.10 Pain Relevance 0
In untreated Fabry patients, uromodulin excretion has been reported as being reduced [32], while we found an increase in the untreated Fabry-Rag mouse model.
Localization (excretion) of uromodulin
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
To assess renal tubular function the urinary excretion of alpha 1-microglobulin, N-acetyl-beta-glucosaminidase and Tamm-Horsfall protein were determined before, immediately, and 12 and 24 hours after ESWL.
Localization (excretion) of Tamm-Horsfall protein
4) Confidence 0.52 Published 1993 Journal J. Urol. Section Abstract Doc Link 7685425 Disease Relevance 0.31 Pain Relevance 0.09
To assess renal function the urinary excretions of beta 2-microglobulin, albumin and Tamm-Horsfall protein were determined by radioimmunoassay.
Spec (determined) Localization (excretions) of Tamm-Horsfall protein
5) Confidence 0.19 Published 1995 Journal J. Urol. Section Abstract Doc Link 7861490 Disease Relevance 0.23 Pain Relevance 0.12
secretion by PMA-differentiated human monocytic cell line (THP-1) stimulated with increasing concentrations of Hz or MSU.
Localization (secretion) of THP-1 in THP-1
6) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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