INT51243

Context Info Confidence 0.33 First Reported 1993 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 0.52 Pain Relevance 0.18

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod) plasma membrane (Umod)

Anatomy Link Frequency urine 2 tubules 1 Umod (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 4 73.64 antagonist 1 64.40 peripheral neuropathy 6 5.00 Spinal cord 4 5.00 Neuropathic pain 4 5.00 Peripheral nervous system 4 5.00 analgesia 2 5.00 hypoalgesia 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Shock 8 89.04 Fabry Disease 36 5.00 Disease 22 5.00 Gauchers Disease 14 5.00 Nociception 6 5.00 Peripheral Neuropathy 6 5.00 Neuropathic Pain 6 5.00 Targeted Disruption 4 5.00 Cerebrovascular Disease 4 5.00 Disease Progression 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Combined ERT and SRT is most effective at reducing uromodulin levels in the urine of Fabry-Rag mice

Negative_regulation (reducing) of uromodulin in urine

1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0

Figure 5 shows that although monotherapy by SRT and ERT had some ability to decrease urine uromodulin concentrations (20–25% reduction compared to untreated), combining ERT and SRT appeared to result in an additive effect, reducing uromodulin concentrations by at least 50%.

Negative_regulation (reducing) of uromodulin in urine

2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0

Tamm-Horsfall protein, a glycoprotein synthesized by the distal tubules, decreased significantly less in the verapamil group compared to the controls.

Negative_regulation (decreased) of Tamm-Horsfall protein in tubules

3) Confidence 0.28 Published 1993 Journal J. Urol. Section Abstract Doc Link 7685425 Disease Relevance 0.31 Pain Relevance 0.07

After ESWL there was a significant increase in urinary beta 2-microglobulin and albumin (p < 0.001), and the urinary Tamm-Horsfall protein decreased significantly (p < 0.01) compared with before ESWL in group 1.

Negative_regulation (decreased) of Tamm-Horsfall protein

4) Confidence 0.10 Published 1995 Journal J. Urol. Section Abstract Doc Link 7861490 Disease Relevance 0.22 Pain Relevance 0.11

General Comments

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