INT51269

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Context Info
Confidence 0.56
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 27
Disease Relevance 10.16
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocyte 4
leukocyte 3
muscle 3
neutrophils 3
blood 1
HIST2H2AA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rapifen 4 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
analgesia 1 100.00 Very High Very High Very High
substance P 297 99.92 Very High Very High Very High
antagonist 198 99.14 Very High Very High Very High
Inflammatory mediators 154 99.12 Very High Very High Very High
Inflammation 607 98.34 Very High Very High Very High
calcitonin gene related peptide 176 98.30 Very High Very High Very High
Inflammatory response 143 97.88 Very High Very High Very High
chemokine 99 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 100.00 Very High Very High Very High
INFLAMMATION 872 99.12 Very High Very High Very High
Esophageal Disease 242 99.08 Very High Very High Very High
Dyspnea 1 98.88 Very High Very High Very High
Stress 20 97.72 Very High Very High Very High
Muscle Hypertonia 11 95.92 Very High Very High Very High
Heart Rate Under Development 8 95.92 Very High Very High Very High
Adhesions 198 95.36 Very High Very High Very High
Pneumothorax 5 94.60 High High
Alzheimer's Dementia 36 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An active negative pressure of 20 cm H2O was applied.
Gene_expression (pressure) of H2O
1) Confidence 0.56 Published 2008 Journal Rozhl Chir Section Abstract Doc Link 18810926 Disease Relevance 1.04 Pain Relevance 0.21
The placental transfer of three opioids used in peridural analgesia, fentanyl, alfentanil and sufentanil, and two reference substances, antipyrine and *H2O, was determined ex vivo in the human placental cotyledon system. (1) In the first set of experiments, the infusion rates were constant and fixed at physiological flow rates.
Spec (determined) Gene_expression (transfer) of H2O associated with rapifen, opioid and analgesia
2) Confidence 0.18 Published 1997 Journal Biol. Neonate Section Abstract Doc Link 9303211 Disease Relevance 0 Pain Relevance 0.40
When DFO was modified by conjugation with hydroxyethyl starch, it lost the ability to produce the radical either by neutrophils or by MPO-H2O2 and did not increase HOCl production.
Gene_expression (produce) of MPO-H2O2 in neutrophils associated with urological neuroanatomy
3) Confidence 0.07 Published 1993 Journal Free Radic. Biol. Med. Section Abstract Doc Link 7686874 Disease Relevance 0.59 Pain Relevance 0.07
At airway pressures of 12, 25, and 32 cm H2O, the airways were larger after aerosol challenge than after the local challenge (P<0.05).
Gene_expression (pressures) of H2O
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859932 Disease Relevance 0 Pain Relevance 0
It has been reported that H2O2 can induce APP expression and thereby enhance A?
Gene_expression (expression) of H2O2
5) Confidence 0.02 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.90 Pain Relevance 0.04
The increase was not affected by a CGRP antagonist or by IL-8 neutralization, suggesting that neither CGRP nor IL-8, at the concentrations present in the supernatant, play a role in inducing H2O2 production by PBL.
Gene_expression (production) of H2O2 associated with calcitonin gene related peptide and antagonist
6) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.22 Pain Relevance 0.68
These findings suggest that H2O2 may be present in circular muscle of esophagitis LES, and responsible for reduced tone when inflammation is present.
Gene_expression (present) of H2O2 in muscle associated with esophageal disease and inflammation
7) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.95 Pain Relevance 0.12
In contrast, a PAF antagonist and a neurokinin-1 receptor antagonist (ie, SP antagonist) significantly reduce supernatant-induced H2O2 production.
Gene_expression (production) of H2O2 associated with antagonist and substance p
8) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.39 Pain Relevance 0.76
While activated PBL produce inflammatory products other than H2O2, H2O2 may be used as a model for PBL-derived ROS because H2O2 is physiologically produced in large amounts by cells such as granulocytes, is relatively stable and has been widely used to assess the effects of ROS.79
Gene_expression (produced) of H2O2 in granulocytes associated with inflammation
9) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.18 Pain Relevance 0.49
PAF and IL-8 produced by epithelial cells, together with SP released from submucosal neurons attract peripheral blood leukocytes, that are activated by both PAF and SP to produce H2O2.
Gene_expression (produce) of H2O2 in blood associated with substance p
10) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.64 Pain Relevance 0.36
This indicates that PAF is a major mucosa-derived mediator depressing muscle contraction.41 PAF can also activate the esophageal circular muscle to secrete IL-6.41 The muscle-derived IL-6 then leads to enhanced production of H2O2, which in turn induces the secretion of IL-1.41,42 H2O2 and IL-1 can themselves induce PAF production (Fig. 13).
Gene_expression (production) of H2O2 in muscle
11) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.36 Pain Relevance 0.21
Upregulation of NOXs is a possible mechanism for overproduction of H2O2.
Gene_expression (overproduction) of H2O2
12) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.05 Pain Relevance 0.11
In circular muscle, PAF causes production of IL-6, and IL-6 causes production of additional H2O2, through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases.
Gene_expression (production) of H2O2 in muscle
13) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Abstract Doc Link PMC2978390 Disease Relevance 0.40 Pain Relevance 0.83
In addition to affecting circular muscle contraction, PAF induces production of H2O2 in leukocytes (preferentially in eosinophils)60 and is among the most important inducers of eosinophil function.
Gene_expression (production) of H2O2 in eosinophil
14) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.61 Pain Relevance 0.24
The data suggest that PBL migration and H2O2 production may be different functions, possibly depending on different signal transduction pathways.
Gene_expression (production) of H2O2
15) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.44 Pain Relevance 0.77
PAF and SP activate peripheral blood leukocytes inducing the production of H2O2.
Gene_expression (production) of H2O2 in leukocytes associated with substance p
16) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Abstract Doc Link PMC2978390 Disease Relevance 0.28 Pain Relevance 0.80
Effect of tourniquet-applied upper limb orthopaedic surgery on leukocyte H2O2 production
Gene_expression (production) of H2O2 in leukocyte
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
This was indicated by the increase in intracellular H2O2 production of monocytes and neutrophils.
Gene_expression (production) of H2O2 in neutrophils
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.63 Pain Relevance 0.10
Specifically, neutrophil intracellular H2O2 production increased from baseline (274.76±107.14), during 5 minutes (301.58±125.09) and 15 minutes (340.54±150.76) reperfusion, whilst monocyte intracellular H2O2 production increased from baseline (170.33±86.22), during 5 minutes (200.09±90.95) and 15 minutes (255.21±111.97) reperfusion.
Gene_expression (production) of H2O2 in monocyte
19) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
CD62L, CD11b and the intracellular production of H2O2 were measured to assess leukocyte function.
Gene_expression (production) of H2O2 in leukocyte
20) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.24 Pain Relevance 0.12

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