INT51474

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 55
Total Number 64
Disease Relevance 44.99
Pain Relevance 20.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 5
mast cell 3
coronary artery 2
blood 1
Dorsal root 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 801 100.00 Very High Very High Very High
cytokine 189 100.00 Very High Very High Very High
Sciatic nerve 70 99.98 Very High Very High Very High
spinal inflammation 8 99.84 Very High Very High Very High
Serotonin 5 99.84 Very High Very High Very High
bDMF 213 99.80 Very High Very High Very High
depression 6 99.80 Very High Very High Very High
Inflammatory response 39 99.76 Very High Very High Very High
Sciatica 11 99.76 Very High Very High Very High
antagonist 29 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 932 100.00 Very High Very High Very High
Coronary Artery Disease 120 100.00 Very High Very High Very High
Death 83 100.00 Very High Very High Very High
Myocardial Infarction 82 100.00 Very High Very High Very High
Cancer 58 100.00 Very High Very High Very High
Necrosis 40 100.00 Very High Very High Very High
Fatigue 26 100.00 Very High Very High Very High
Insulin Resistance 12 100.00 Very High Very High Very High
Low Back Pain 10 99.84 Very High Very High Very High
Depression 8 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An interaction between the IL6 haplotype and physical work load was significant for the duration of back and leg pain and sick leave (p=0.038, 0.011 and 0.006, respectively).
IL6 Binding (interaction) of in leg
1) Confidence 0.48 Published 2008 Journal Eur J Pain Section Body Doc Link 18321738 Disease Relevance 0.06 Pain Relevance 0
In the present study, the potential association between fatigue and plasma interleukin-6 (IL-6) was examined in 46 terminally ill cancer patients (median survival: 64.5 days) who received neither steroids nor nonsteroidal anti-inflammatory drugs.
IL-6 Binding (association) of in plasma associated with inflammation, cancer, cinod and fatigue
2) Confidence 0.48 Published 2008 Journal J Pain Symptom Manage Section Abstract Doc Link 18082358 Disease Relevance 1.66 Pain Relevance 0.14
The specific timing of the medication, linked to the interaction between IL-6 and the hypothalamic-pituitary-adrenal (HPA) axis, may correct a postulated deficiency in HPA control in RA.
IL-6 Binding (interaction) of in pituitary associated with rheumatoid arthritis
3) Confidence 0.48 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20398018 Disease Relevance 0.53 Pain Relevance 0.41
In the present study, the potential association between fatigue and plasma interleukin-6 (IL-6) was examined in 46 terminally ill cancer patients (median survival: 64.5 days) who received neither steroids nor nonsteroidal anti-inflammatory drugs.
interleukin-6 Binding (association) of in plasma associated with inflammation, cancer, cinod and fatigue
4) Confidence 0.48 Published 2008 Journal J Pain Symptom Manage Section Abstract Doc Link 18082358 Disease Relevance 1.66 Pain Relevance 0.14
These data suggest that IL6 is associated with breast cancer risk and modifies the association between estrogen and aspirin and breast cancer risk.
IL6 Binding (associated) of associated with aspirin and breast cancer
5) Confidence 0.46 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416766 Disease Relevance 0.58 Pain Relevance 0.29
Alternatively, IL-6 can bind to a soluble IL-6 receptor (sIL-6R), and the IL-6/sIL-6R complex can bind to the transmembrane signal-transducing subunit gp130 of cells which do not express the membrane-bound IL-6R, thus leading to IL-6 transsignalling [5].
IL-6 Binding (bind) of
6) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.82 Pain Relevance 0.43
The sensitizing effect of IL-6 was prevented by co-administration of sgp130 which binds and inactivates IL-6/IL-6R complexes [5].
IL-6 Binding (binds) of
7) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.48 Pain Relevance 0.44
To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC.
IL-6 Binding (association) of associated with restless leg syndrome
8) Confidence 0.42 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11583728 Disease Relevance 0.67 Pain Relevance 0.45
The receptor for IL-6 is found on many cell surfaces including resting normal T-cells, activated normal B-cells, myeloid cell lines and others.
IL-6 Binding (receptor) of in T-cells
9) Confidence 0.37 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.58 Pain Relevance 0.27
When injected intraperitoneally, the opiate antagonist naloxone hydrochloride, antagonized the IL-6 response induced by either i.c.v. or i.p.
IL-6 Binding (antagonized) of associated with antagonist, narcan and opiate
10) Confidence 0.37 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817528 Disease Relevance 0.17 Pain Relevance 0.92
Blood was collected by direct cardiac puncture immediately after the 2-h experiments and assayed for the cytokines IL-6 and IL-1beta by ELISA.
IL-6 Binding (assayed) of in puncture associated with cytokine
11) Confidence 0.37 Published 2002 Journal Pediatr. Res. Section Abstract Doc Link 12438666 Disease Relevance 0.80 Pain Relevance 0.25
Since both, IL-6 and PGE2 have been shown to be associated with inflammatory responses and anti-inflammatory repair mechanisms, the temporality of induction of each mediator, likely play a crucial role in their functionality.
IL-6 Binding (associated) of associated with inflammatory response and inflammation
12) Confidence 0.36 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.45 Pain Relevance 0.23
Therefore, we investigated the association between IL-6 polymorphism and levels of IL-6 in patients with coronary artery disease (CAD).
IL-6 Binding (association) of in coronary artery associated with coronary artery disease
13) Confidence 0.35 Published 2008 Journal Coron. Artery Dis. Section Abstract Doc Link 18281810 Disease Relevance 0.70 Pain Relevance 0.16
OBJECTIVE: To investigate the association of serum levels of two key mast cell mediators, interleukin-6 (IL-6) and tryptase, to each other and with disease severity in patients with mastocytosis.
interleukin-6 Binding (association) of in mast cell
14) Confidence 0.35 Published 2002 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 12218373 Disease Relevance 0.10 Pain Relevance 0
Dorsal root sensitivity to interleukin-1 beta, interleukin-6 and tumor necrosis factor in rats.
interleukin-6 Binding (sensitivity) of in Dorsal root associated with necrosis, cancer and cytokine
15) Confidence 0.35 Published 2002 Journal Eur Spine J Section Title Doc Link 12384756 Disease Relevance 0.96 Pain Relevance 0.97
Interleukin-6 serum concentration in ankylosing spondylitis: a reliable predictor of disease progression in the subsequent year?
Interleukin-6 Binding (concentration) of associated with spinal inflammation and disease progression
16) Confidence 0.35 Published 2000 Journal Rheumatol. Int. Section Title Doc Link 10836525 Disease Relevance 0.47 Pain Relevance 0.38
Furthermore, reasons for the significant transient elevation of IL-6 mRNA are not possible to discern; however, the dual association of IL-6 with both contractile dysfunction [43] and cardioprotection [44] is intriguing and worthy of further investigation.
IL-6 Binding (association) of
17) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.18 Pain Relevance 0.03
OBJECTIVE: To investigate the possible association between the recently described interleukin 6 (IL-6) promoter polymorphisms at position -174, and susceptibility to ankylosing spondylitis (AS).
IL-6 Binding (association) of associated with spinal inflammation
18) Confidence 0.32 Published 2000 Journal J. Rheumatol. Section Abstract Doc Link 10852271 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the possible association between the recently described interleukin 6 (IL-6) promoter polymorphisms at position -174, and susceptibility to ankylosing spondylitis (AS).
interleukin 6 Binding (association) of associated with spinal inflammation
19) Confidence 0.32 Published 2000 Journal J. Rheumatol. Section Abstract Doc Link 10852271 Disease Relevance 0.17 Pain Relevance 0.17
Stavudine administration did not affect the plasma concentration of IL-6, CINC-1, adiponectin or lactate.
IL-6 Neg (not) Binding (concentration) of in plasma
20) Confidence 0.32 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19442827 Disease Relevance 0.81 Pain Relevance 0.88

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