INT51584

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 3.21
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ1) transmembrane transport (KCNQ1)
Anatomy Link Frequency
cardiac myocytes 1
KCNQ1 (Homo sapiens)
KCNQ1 - A341V (1)
Pain Link Frequency Relevance Heat
potassium channel 20 99.68 Very High Very High Very High
Neurotransmitter 18 98.92 Very High Very High Very High
gABA 7 95.12 Very High Very High Very High
tetrodotoxin 6 94.44 High High
addiction 7 92.52 High High
opiate 4 92.12 High High
Analgesic 4 90.52 High High
Neuropathic pain 2 85.20 High High
isoflurane 2 85.04 High High
Dopamine 4 83.52 Quite High
Disease Link Frequency Relevance Heat
Syndrome 270 100.00 Very High Very High Very High
Arrhythmia Under Development 31 96.72 Very High Very High Very High
Nonsyndromic Deafness 2 95.44 Very High Very High Very High
Opiate Addiction 4 92.52 High High
Cognitive Disorder 4 88.52 High High
Epilepsy 4 85.72 High High
Neuropathic Pain 2 85.20 High High
Symphalangism 5 84.24 Quite High
Bordatella Infection 22 82.72 Quite High
Targeted Disruption 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To understand the mechanism underlying these clinical findings, we examined the effects of l-alpha-acetylmethadol on the cloned human cardiac K(+) channels HERG (human ether-a-go-go-related gene), KvLQT1/minK and Kv4.3.
Spec (examined) Regulation (effects) of KvLQT1
1) Confidence 0.44 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.19 Pain Relevance 0.23
However, a large cooperative study providing detailed clinical information on 187 J-LN patients has allowed the recognition of clear differences versus the other types of LQTS including LQT1, the variant which shares with J-LN an impairment in the IKs current.
Spec (clear) Regulation (recognition) of LQT1 associated with syndrome
2) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.67 Pain Relevance 0.04
In a collaborative study focusing on the hot spot KCNQ1-A341V (a common mutation present worldwide and responsible for a major founder effect in almost 25 South African families), they have demonstrated that the unusually high clinical severity already reported by Brink et al. [24] for the South African families is present also among LQT1 patients from different ethnic backgrounds but carrying the same A341V mutation.
Regulation (responsible) of KCNQ1 (A341V)
3) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 0.06 Pain Relevance 0
Transmural heterogeneities in IKs and transient outward current (Ito) were simulated as in previous studies (McIntosh et al. 2000; Gima & Rudy 2002).
Regulation (simulated) of IKs
4) Confidence 0.29 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.07
The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Regulation (affects) of Kv7 associated with potassium channel
5) Confidence 0.26 Published 2006 Journal Neuropharmacology Section Title Doc Link 16904708 Disease Relevance 0.26 Pain Relevance 0.22
Isoproterenol reduced the VERP dispersion in LQT2 rabbits by shortening the VERP in the base more than in the apex but had no effect on VERP in LQT1.
Neg (no) Regulation (effect) of LQT1
6) Confidence 0.23 Published 2010 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 20581090 Disease Relevance 0.13 Pain Relevance 0.18
In conclusion, (S)-1 differentially affects the Kv7 channel subtypes and is dependent on a single tryptophan for the current enhancing effect in Kv7.4.
Regulation (affects) of Kv7
7) Confidence 0.22 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.18 Pain Relevance 0.13
The major active metabolite of l-alpha-acetylmethadol, noracetylmethadol, inhibited HERG with an estimated IC(50) values of 12 microM. l-alpha-acetylmethadol had little or no effect on Kv4.3 or KvLQT1/minK K(+) channel currents at concentration up to 10 microM.
Neg (no) Regulation (effect) of KvLQT1
8) Confidence 0.12 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.15 Pain Relevance 0.29
The effect of retigabine persisted in the presence of tetrodotoxin and simultaneous blockade of GABA(A) receptors, small-conductance calcium-activated K(+) (SK) channels, and hyperpolarization-activated (I(h)) channels, and it was potently reversed by the KCNQ channel blocker 4-pyridinylmethyl-9(10H)-anthracenone (XE991), indicating a direct effect on KCNQ channels.
Regulation (effect) of KCNQ associated with tetrodotoxin and gaba
9) Confidence 0.08 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16775195 Disease Relevance 0 Pain Relevance 0.26
This pro-arrhythmic effect is due largely to the fact that HF, like mefloquine and lumefantrine, acts upon cardiac myocytes to block the potassium channels which initiate repolarization and determine the QT interval under genetic regulation (LQT1 and HERG genes) [16,17].
Spec (determine) Regulation (regulation) of LQT1 in cardiac myocytes associated with potassium channel
10) Confidence 0.03 Published 2009 Journal Malar J Section Body Doc Link PMC2801676 Disease Relevance 0.41 Pain Relevance 0.09
Selective vagotomy and adrenalectomy failed to affect gastric adaptation to WRS, whereas gastric acid inhibition by ranitidine enhanced this adaptation.
Neg (failed) Regulation (affect) of WRS
11) Confidence 0.01 Published 1995 Journal Scand. J. Gastroenterol. Section Body Doc Link 7701252 Disease Relevance 0 Pain Relevance 0
Although quite a number of these various K+ channels were reported to be modulated by neurotransmitters, the most intensively studied examples of K+ channel regulation via G protein-coupled receptors are inward rectifier (Kir) channels and KCNQ channels which are now classified as KV7 family [51].
Regulation (regulation) of KCNQ associated with neurotransmitter
12) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.16 Pain Relevance 0.10
Hence, the regulation of Ca2+ channels and Ca2+-dependent K+ channels via P2Y receptors will preferentially lead to changes in synaptic transmission via a presynaptic modulation of transmitter release, whereas the control of GIRKs and KCNQ channels will rather cause changes in the postsynaptic excitability.
Regulation (control) of KCNQ
13) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.24

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