INT51686

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Context Info
Confidence 0.26
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.02
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
osteoblasts 6
platelet 4
PMNs 2
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 67 100.00 Very High Very High Very High
diclofenac 4 100.00 Very High Very High Very High
Paracetamol 4 100.00 Very High Very High Very High
Osteoarthritis 525 99.84 Very High Very High Very High
Inflammation 80 93.04 High High
corticosteroid 36 81.44 Quite High
COX-2 inhibitor 20 69.68 Quite High
licofelone 4 61.08 Quite High
dexamethasone 21 36.00 Quite Low
Pain 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 111 100.00 Very High Very High Very High
Osteoarthritis 530 99.84 Very High Very High Very High
Occupational Lung Diseases 37 99.60 Very High Very High Very High
Nicotine Addiction 4 98.28 Very High Very High Very High
Asthma 101 96.00 Very High Very High Very High
Coagulation Disorder 1 94.20 High High
Osteoporosis 25 78.76 Quite High
Toxicity 4 66.56 Quite High
Apoptosis 1 61.28 Quite High
Disease 72 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Regulation (effects) of Gene_expression (production) of LTB4 in platelet associated with paracetamol, cinod and diclofenac
1) Confidence 0.26 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.17 Pain Relevance 0.60
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Regulation (effects) of Gene_expression (migration) of LTB4 in platelet associated with paracetamol, cinod and diclofenac
2) Confidence 0.26 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.17 Pain Relevance 0.60
A study was made to compare the effects of two nonsteroidal antiinflammatory drugs (NSAIDs), flunixin and tolfenamic acid, on the leukotriene B4 (LTB4) production and migration of human polymorphonuclear leukocytes (PMNs) as well as on platelet aggregation and thromboxane B2 (TxB2) production during blood clotting.
Regulation (effects) of in PMNs Gene_expression (production) of LTB4 in polymorphonuclear leukocytes associated with coagulation disorder, inflammation and cinod
3) Confidence 0.02 Published 1993 Journal Inflammation Section Abstract Doc Link 8406686 Disease Relevance 0.19 Pain Relevance 0.10
Because LTB4 biosynthesis by AMs in vitro can be modulated by environmental factors in vivo, such as cigarette smoking [32], smokers were excluded from the study.
Regulation (modulated) of Gene_expression (biosynthesis) of LTB4 associated with nicotine addiction
4) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.22 Pain Relevance 0.07
Another feature in MTOI solutions is that when multiple targets are inhibited simultaneously, a mild inhibition of each target is sufficient to achieve effective control of LTB4 and PGE2 production and there is a much larger therapeutic window.
Regulation (control) of Gene_expression (production) of LTB4
5) Confidence 0.01 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.16 Pain Relevance 0.11
On the basis of PGE2 production, we next questioned what mechanism or mechanisms were responsible for the alteration of LTB4 production.
Regulation (responsible) of Gene_expression (production) of LTB4
6) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.64 Pain Relevance 0.32
On the basis of PGE2 production, we next questioned what mechanism or mechanisms were responsible for the alteration of LTB4 production.
Regulation (alteration) of Gene_expression (production) of LTB4
7) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.64 Pain Relevance 0.32
We then evaluated the modulation of LTB4 production in OA osteoblasts by 1,25(OH)2D3, transforming growth factor-?
Regulation (modulation) of Gene_expression (production) of LTB4 in osteoblasts associated with osteoarthritis
8) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.64 Pain Relevance 0.35
The modulation of LTB4 production in OA osteoblasts was also linked to alterations of FLAP expression in these cells in response to 1,25(OH)2D3 and TGF-?
Regulation (modulation) of Gene_expression (production) of LTB4 in osteoblasts associated with osteoarthritis
9) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.55 Pain Relevance 0.24
indicate that the production of LTB4 is more sensitive to 1,25(OH)2D3 treatment through its effect on FLAP expression, especially in the high OA osteoblasts group, whereas the production of PGE2 is sensitive to TGF-?
Regulation (sensitive) of Gene_expression (production) of LTB4 in osteoblasts associated with osteoarthritis
10) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.64 Pain Relevance 0.28

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