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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 2
pituitary 2
spinal cord dorsal horn 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 1 100.00 Very High Very High Very High
Spinal cord 3 98.56 Very High Very High Very High
Dorsal horn 2 98.08 Very High Very High Very High
agonist 1 85.84 High High
gABA 2 85.40 High High
Neurotransmitter 1 76.12 Quite High
Pain 4 72.24 Quite High
anesthesia 1 61.84 Quite High
cva 1 49.76 Quite Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Natriuresis 2 100.00 Very High Very High Very High
Body Weight 1 100.00 Very High Very High Very High
Spasticity 3 99.48 Very High Very High Very High
Pressure And Volume Under Development 3 78.92 Quite High
Hemorrhage 1 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the impact of changes in the level of the endogenous atrial natriuretic factor (ANF) on pituitary-adrenocortical activity, the secretion of corticotropin (ACTH) and corticosterone was studied under the conditions of enhanced and decreased circulating ANF levels in rats.
Positive_regulation (enhanced) of Negative_regulation (decreased) of ANF in pituitary associated with natriuresis
1) Confidence 0.47 Published 1994 Journal Endocr Regul Section Abstract Doc Link 7711293 Disease Relevance 0.10 Pain Relevance 0.06
The clinical effect of Baclofen on the reduction of spasticity might be explained by an enhancement of GABAergic inhibition of ANP mediated cGMP concentration in the spinal cord dorsal horn, thus reducing afferent input.
Positive_regulation (enhancement) of Negative_regulation (inhibition) of ANP in spinal cord dorsal horn associated with spasticity, gabaergic, dorsal horn and spinal cord
2) Confidence 0.43 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11872270 Disease Relevance 0.27 Pain Relevance 0.44
Spironolactone induced a significant reduction of plasma volume (42.1 +/- 5.5 to 36.1 +/- 6.6 mL/kg body weight, P < .01) and of the concentration of alpha-atrial natriuretic peptide (alpha-ANP) (39.8 +/- 22 to 27.7 +/- 20 pg/mL, P < .01); in addition, a pronounced increase in plasma renin activity (PRA) (1.1 +/- 0.9 to 7.5 +/- 3.4 ng/mL/h, P < .001) was induced by the treatment.
Positive_regulation (induced) of Negative_regulation (reduction) of alpha-ANP in plasma associated with natriuresis and body weight
3) Confidence 0.04 Published 1996 Journal Hepatology Section Abstract Doc Link 8621132 Disease Relevance 0.43 Pain Relevance 0.07

General Comments

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