INT51734

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Context Info
Confidence 0.19
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.53
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
plasma 4
heart 4
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 51 98.64 Very High Very High Very High
ischemia 22 97.60 Very High Very High Very High
dorsal root ganglion 1 97.44 Very High Very High Very High
lidocaine 8 96.78 Very High Very High Very High
Mexiletine 8 96.52 Very High Very High Very High
antagonist 3 90.00 High High
qutenza 18 88.48 High High
Neurotransmitter 2 85.28 High High
antiarrhythmic agent 2 74.88 Quite High
metalloproteinase 29 27.52 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 18 97.60 Very High Very High Very High
Ganglion Cysts 1 97.44 Very High Very High Very High
Necrosis 6 90.64 High High
Cancer 5 90.28 High High
Reperfusion Injury 4 85.28 High High
Coronary Artery Disease 4 79.64 Quite High
Heart Neoplasms 1 75.00 Quite High
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 17 5.00 Very Low Very Low Very Low
Lung Injury 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with rutaecarpine (100 or 300 microg/kg, i.v.) significantly reduced infarct size and creatine kinase release concomitantly with a significant increase in plasma concentrations of CGRP.
Negative_regulation (reduced) of Localization (release) of kinase in plasma
1) Confidence 0.19 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12763639 Disease Relevance 0.29 Pain Relevance 0.49
Pretreatment with nitroglycerin at the concentration of 3x10(-7) or 10(-6) M for 5 min produced a significant improvement of cardiac function and a decrease in the release of creatine kinase.
Negative_regulation (decrease) of Localization (release) of kinase
2) Confidence 0.11 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10206178 Disease Relevance 0.09 Pain Relevance 0.55
Pretreatment with monophosphoryl lipid A (500 microg/kg, i.p.) for 24 h improved the recovery of cardiac function and reduced the release of creatine kinase concomitantly with a decrease in the content of cardiac TNF-alpha.
Negative_regulation (reduced) of Localization (release) of kinase
3) Confidence 0.10 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11408036 Disease Relevance 0.24 Pain Relevance 0.42
Contractile dysfunction was associated with increases in tissue Na+ and Ca2+ levels, decreases in K+ and Mg2+ levels, and release of creatine kinase and purine nucleosides and bases (ATP metabolites) from the heart.
Negative_regulation (decreases) of Localization (release) of kinase in heart
4) Confidence 0.08 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7713159 Disease Relevance 0.40 Pain Relevance 0.72
Treatment of the perfused heart with either 10-100 microM of either mexiletine or lidocaine during pre-ischemia resulted in an enhancement of post-ischemic contractile recovery, a suppression of changes in tissue Na+, K+, Ca2+ and Mg2+ contents and an attenuation of the release of creatine kinase and ATP metabolites in an almost concentration-dependent manner.
Negative_regulation (attenuation) of Localization (release) of kinase in heart associated with ischemia, mexiletine and lidocaine
5) Confidence 0.08 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7713159 Disease Relevance 0.39 Pain Relevance 0.68
Pretreatment with preconditioning significantly reduced infarct size and the release of creatine kinase during reperfusion, and caused a significant increase in the expression of CGRP mRNA, concomitantly with an elevation in the plasma level of CGRP and NO.
Negative_regulation (reduced) of Localization (release) of kinase in plasma associated with calcitonin gene-related peptide
6) Confidence 0.07 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464099 Disease Relevance 0.43 Pain Relevance 0.69
Nitroglycerin (60 microg/kg or 120 microg/kg) caused an improvement of cardiac function, a decrease in the release of creatine kinase in coronary effluent and a decrease in the content of TNF-alpha in myocardial tissues.
Negative_regulation (decrease) of Localization (release) of kinase
7) Confidence 0.07 Published 2001 Journal Int. J. Cardiol. Section Abstract Doc Link 11744139 Disease Relevance 0.18 Pain Relevance 0.16
Pretreatment with nitroglycerin (60 or 120 microg/kg i.v.) reduced both the infarct size and the release of creatine kinase during reperfusion and caused a significant increase in the expression of alpha-CGRP mRNA, but not beta-CGRP mRNA, concomitantly with an increase in concentrations of NO and CGRP.
Negative_regulation (reduced) of Localization (release) of kinase associated with calcitonin gene-related peptide
8) Confidence 0.06 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11919648 Disease Relevance 0 Pain Relevance 0.63
However, ischemic preconditioning (three cycles of 5-min ischemia and 5-min reperfusion) or pretreatment with CGRP for 5 min dramatically improved the recovery of cardiac function, and reduced the release of cardiac creatine kinase and the TNF-alpha content.
Negative_regulation (reduced) of Localization (release) of kinase associated with ischemia and calcitonin gene-related peptide
9) Confidence 0.06 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11068026 Disease Relevance 0.51 Pain Relevance 0.62
Saline or kinase inhibitors alone had little effect on NF-?
Negative_regulation (inhibitors) of Localization (Saline) of kinase
10) Confidence 0.02 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0 Pain Relevance 0

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