INT5198
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
We confirmed inhibition of VTA DA activity in MD rats in response to precipitated withdrawal; however, this inhibition resulted only in a normalization of the firing rate to that of naive animals. | |||||||||||||||
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Pretreatment with RX821002 plus clonidine prevented the inhibition of VTA DA activity during withdrawal but failed to produce excitation. | |||||||||||||||
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Intriguingly, the LS extracellular levels of DA returned to basal values before the VTA GABA extracellular levels recovered. | |||||||||||||||
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Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine. | |||||||||||||||
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Prenatal ethanol exposure has been shown to produce a persistent reduction in the spontaneous activity of ventral tegmental area (VTA) dopamine (DA) neurons and in DA neurotransmission. | |||||||||||||||
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In contrast, pretreatment with a more selective alpha2R agonist, UK14304, did not prevent the inhibition of VTA DA neuron activity during withdrawal. | |||||||||||||||
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As expected, withdrawal produced a marked inhibition of VTA DA neuronal activity. | |||||||||||||||
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The locomotor effects of nicotine were similarly changed after lesions of the LDTg (Alderson et al. 2005) and, given that the LDTg projects to VTA but not SNC (Oakman et al. 1995), it is likely that in the present experiments it is loss of VTA innervation by pPPTg that is critical. | |||||||||||||||
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Reversible inactivation of VTA was done through the unilateral and bilateral intra-VTA microinjection of 2% lidocaine during the acquisition and expression of morphine (5 mg/kg; s.c.) | |||||||||||||||
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In the present study, the effects of reversible inactivation of VTA on acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in rats. | |||||||||||||||
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This finding represents the first demonstration that chronic exposure to nicotine might result in reduced GABAB-mediated inhibition of VTA dopaminergic neurones. | |||||||||||||||
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Bilateral lesions of the TM, which decreased the histamine levels in the VTA and NAc, potentiated the development of CPP induced by morphine (1 mg/kg, a dose that produced no appreciable effect when given alone) and increased the DOPAC/DA ratios in the VTA and NAc, but did not change the glutamate or GABA levels in these nuclei. | |||||||||||||||
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Because GluR2 is located in VTA dopamine neurons as shown above, these data further support our hypothesis that HU210 induces in vivo transient synaptic depression in VTA dopamine neurons.
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Our data together indicate that cannabinoid injection induces in vivo synaptic depression in VTA dopamine neurons that lasts for less than 24 h. | |||||||||||||||
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Nevertheless, unlike bupropion, the selective DA reuptake inhibitor GBR12909, also known to increase extracellular levels of DA in the cortex [127], decreases both the firing and burst activity of DA neurons in the VTA following a 2-day administration [52]. | |||||||||||||||
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Thus, decreased NF levels in the VTA in response to chronic morphine and chronic cocaine could lead to drug-induced alterations in the structural and functional properties of this brain region, which may represent, in turn, part of a common biochemical basis of morphine and cocaine addiction and craving. | |||||||||||||||
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In contrast, blocking ERK2 activity in the VTA produces stress-resistant behavioral responses in these same assays and also blocks a chronic stress-induced reduction in sucrose preference. | |||||||||||||||
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Similar to NE neurons, the firing rate of DA neurons in the VTA was significantly decreased with the short-term nomifensine regimen (Figure 4). | |||||||||||||||
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The number of TH-positive neurons was decreased in the ipsilateral VTA and SNc as compared to the contralateral side. | |||||||||||||||
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Although the loss of non-dopaminergic neurons in the VTA (which may play an opposing role in sleep regulation) cannot be overruled in these studies, we recently found that selective lesions of VTA dopaminergic neurons using 6-OHDA also did not produce an increase in sleep in rats (R. | |||||||||||||||
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