INT5207

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 70
Total Number 72
Disease Relevance 41.56
Pain Relevance 13.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 6
plasma 2
head 2
optic nerves 2
endothelial cells 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 2 99.90 Very High Very High Very High
Multiple sclerosis 448 99.84 Very High Very High Very High
Central nervous system 812 99.80 Very High Very High Very High
Demyelination 80 99.80 Very High Very High Very High
imagery 203 99.44 Very High Very High Very High
metalloproteinase 64 99.44 Very High Very High Very High
cocaine 47 99.44 Very High Very High Very High
intrathecal 15 99.24 Very High Very High Very High
Spinal cord 296 99.20 Very High Very High Very High
Bioavailability 7 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 13 99.96 Very High Very High Very High
Injury 99 99.92 Very High Very High Very High
Multiple Sclerosis 632 99.84 Very High Very High Very High
Renal Disease 6 99.84 Very High Very High Very High
Demyelinating Disease 270 99.80 Very High Very High Very High
Hypothermia 116 99.72 Very High Very High Very High
Brain Injury 53 99.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 273 99.64 Very High Very High Very High
Autoimmune Disease 153 99.64 Very High Very High Very High
Epilepsy 143 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the phenomenon would certainly be rare [56], one may imagine that some individuals present a genetic deficiency in BBB P-glycoproteins.
Negative_regulation (deficiency) of BBB
1) Confidence 0.41 Published 2003 Journal Filaria J Section Body Doc Link PMC2147657 Disease Relevance 0.06 Pain Relevance 0.04
A variety of occurrences during an anesthetic have been shown to disrupt the BBB.
Negative_regulation (disrupt) of BBB
2) Confidence 0.36 Published 1992 Journal AANA J Section Abstract Doc Link 1292323 Disease Relevance 0 Pain Relevance 0.30
Work done in our laboratory suggest that hyperthermia caused by these drugs is responsible for BBB disruption and neurodegeneration.
Negative_regulation (disruption) of BBB associated with fever
3) Confidence 0.36 Published 2007 Journal Curr. Pharm. Des. Section Abstract Doc Link 17584116 Disease Relevance 0.69 Pain Relevance 0.30
In addition, loperamide efflux at the BBB was inhibited by quinidine.
Negative_regulation (inhibited) of BBB
4) Confidence 0.31 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14698039 Disease Relevance 0.09 Pain Relevance 1.02
Usually, protein binding results in a drastic net decrease in CNS uptake because only free drug is available to cross the BBB [7].
Negative_regulation (cross) of BBB associated with central nervous system
5) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0 Pain Relevance 0.25
Although none of the Group 1 animals showed BBB disruption, 57% of the animals in Group 2 showed marked BBB disruption (3+).
Negative_regulation (disruption) of BBB
6) Confidence 0.25 Published 1986 Journal Neurosurgery Section Abstract Doc Link 3714006 Disease Relevance 0.42 Pain Relevance 0.30
The degree of transient EEG change observed correlates well with the degree of barrier disruption, potentially allowing clinical determination of BBB disruption by this method.
Negative_regulation (disruption) of BBB
7) Confidence 0.25 Published 1986 Journal Neurosurgery Section Abstract Doc Link 3714006 Disease Relevance 0.34 Pain Relevance 0.24
When the BBB is disrupted, Trypan blue extravasates into tissue, resulting in a grossly visible blue stain [14], and thus has been used classically to demonstrate BBB breakdown.
Negative_regulation (disrupted) of BBB
8) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2364662 Disease Relevance 0.51 Pain Relevance 0.04
Recently, we showed disruption of the BBB and BSCB in areas of motor neuron degeneration in the brain and spinal cord in G93A SOD1 mice modeling ALS at both early and late stages of disease using electron microscopy.
Negative_regulation (disruption) of BBB in spinal cord associated with disease, nerve degeneration and spinal cord
9) Confidence 0.18 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2075163 Disease Relevance 0.25 Pain Relevance 0.17
These safer biochemical techniques selectively disrupt the intratumoral BBB while minimally altering the normal BBB 45.
Negative_regulation (disrupt) of BBB
10) Confidence 0.14 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792490 Disease Relevance 0.54 Pain Relevance 0.13
A variety of techniques that transiently disrupt the BBB have been investigated.
Negative_regulation (disrupt) of BBB
11) Confidence 0.14 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792490 Disease Relevance 0.36 Pain Relevance 0.08
These strategies generally fall into one or more of the following three broad categories viz., manipulating drugs, disrupting the BBB, and exploiting alternative routes for drug delivery

ENHANCING BBB PERMEABILITY BY DRUG MANIPULATION

Negative_regulation (disrupting) of BBB
12) Confidence 0.14 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792490 Disease Relevance 0.45 Pain Relevance 0.07
Recently, we showed disruption of the BBB and BSCB in areas of motor neuron degeneration in the brain and spinal cord in G93A SOD1 mice modeling ALS at both early and late stages of disease using electron microscopy [39].
Negative_regulation (disruption) of BBB in motor neuron associated with disease, motor neuron diseases, nerve degeneration and spinal cord
13) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.33 Pain Relevance 0.22
In another report [49], an ALS mouse model with a permissive BBB was created by crossing G93A mouse with the mdr1a/b knockout mouse and showed that cyclosporine A (CsA), which cannot cross an intact BBB, BSCB or BCSFB, reached the CNS when delivered intraperitoneally into this combined mouse model.
Negative_regulation (cross) of BBB associated with targeted disruption, central nervous system and motor neuron diseases
14) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.79 Pain Relevance 0.17
Future experiments directed at putative mechanisms of BBB disruption and demyelination are already underway in our labs.


Negative_regulation (disruption) of BBB associated with demyelination
15) Confidence 0.12 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2474604 Disease Relevance 1.05 Pain Relevance 0.33
Gadolinium-enhanced T1 weighted MRI showed evidence of BBB disruption in these same areas of the brain (F).
Negative_regulation (disruption) of BBB in brain
16) Confidence 0.12 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2474604 Disease Relevance 1.24 Pain Relevance 0.43
Proteins liberated during this process are likely to trap Gf once it passed the disrupted BBB [10].
Negative_regulation (disrupted) of BBB
17) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.28 Pain Relevance 0.23
However, disruption of BBB and BSB is well known in certain pathological states
Negative_regulation (disruption) of BBB
18) Confidence 0.11 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 0.25 Pain Relevance 0.26
Four main routes for molecules to enter the brain include the transcellular pathway (crossing through individual endothelial cells), the paracellular pathway (crossing between adjacent endothelial cells), intrathecal injection into the space surrounding the spinal cord or intracerebral injection (mechanical disruption of BBB by needle).
Negative_regulation (disruption) of BBB in endothelial cells associated with spinal cord and intrathecal
19) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.66 Pain Relevance 0.14
However, in the BBB, the paracellular route is blocked by tight junctions, preventing diffusion of even small molecules such as ions and water.
Negative_regulation (blocked) of BBB
20) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.05 Pain Relevance 0.04

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