INT5211

Context Info Confidence 0.78 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.75 Pain Relevance 0.71

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40) enzyme binding (Cd40)

Anatomy Link Frequency CD86 1 immune cells 1 microglia 1 Cd40 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 98 99.56 Enkephalin 3 92.80 Inflammation 106 72.32 narcan 1 69.52 cINOD 4 58.00 fibrosis 29 56.04 Arthritis 33 55.84 tolerance 8 50.00 chemokine 19 47.40 Central nervous system 37 35.44

Disease Link Frequency Relevance Heat Alzheimer's Dementia 64 99.96 Cancer 5 98.88 Necrosis 5 98.64 Stress 3 76.00 INFLAMMATION 102 72.32 Targeted Disruption 17 71.40 Amyloid Plaque 14 66.32 Gliosis 2 59.76 Pressure And Volume Under Development 9 58.32 Fibrosis 11 56.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was shown that the peptide did not influence secretion of IgM-antibody to T-independent antigen-trinitrobenzensulfoacidic group, but suppressed secretion of IgG-antibody to T-dependent antigens both during primary and secondary response.

Localization (secretion) of IgM

1) Confidence 0.78 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1292695 Disease Relevance 0 Pain Relevance 0.27

siRNA sequence (TGTTCCACTGGGCTGAGAA), specifically targeting the CD40 gene, was designed and synthesized by Dhmarcon (Dharmacon, Inc., Chicago, IL, USA).

Localization (targeting) of CD40

2) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.22 Pain Relevance 0.03

Together with Ruslan Mezhitov, he originated the concept that these phagocytic innate immune cells recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors, the most notable examples being a set of phylogenetically conserved, germ-line encoded Toll-like receptors (TLRs, currently 11–12 members, [7-10]), resulting in expression of cell-surface activation molecules [for example, major histocompatibility complex (MHC) class I and II, B7.1, B7.2, and CD40] and secretion of innate cytokines [i.e., tumor necrosis factor ?

Localization (secretion) of CD40 in immune cells associated with necrosis, cancer and cytokine

3) Confidence 0.64 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.20 Pain Relevance 0.05

secretion versus CD40L-sufficient AD mouse microglia [42].

Localization (secretion) of CD40L-sufficient in microglia associated with alzheimer's dementia

4) Confidence 0.64 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.03 Pain Relevance 0.14

They were then stained for anti-CD40, anti-CD80, anti-CD86, anti-H-2kd (all 1?

Localization (anti) of CD40 in CD86

5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.07 Pain Relevance 0.08

TNF pathway group (19 transcripts): TNF, TNFSF10, TNFSF14, TNFRSF1A, TNFRSF1B, TNFRSF10B, CD27, CD40, LTBR, TNFAIP3, TRAF2, TRAF3, TRADD, TBK1, FADD, CFLAR, RIPK1, RIPK2, and MAP3K1, B.

Localization (group) of CD40

6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

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