INT52454

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.53
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp)
cytoplasm (Tbp)
Tbp (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 2 99.84 Very High Very High Very High
dexamethasone 4 92.80 High High
agonist 22 91.80 High High
narcan 3 91.56 High High
long-term potentiation 63 85.12 High High
Action potential 5 79.28 Quite High
cva 54 72.24 Quite High
Hippocampus 11 50.44 Quite High
depression 3 21.28 Low Low
Pyramidal cell 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 45 99.40 Very High Very High Very High
Apoptosis 60 99.32 Very High Very High Very High
Disease 23 99.32 Very High Very High Very High
Stress 15 98.68 Very High Very High Very High
Neurodegenerative Disease 20 97.88 Very High Very High Very High
Pressure Volume 2 Under Development 3 90.60 High High
Cv General 4 Under Development 54 72.24 Quite High
Depression 3 21.28 Low Low
Cognitive Disorder 7 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TBP localization could not be demonstrated in spite of repeated attempts at amplifying the region spanning the predicted Sp1 site (Fig. 4C, lower).
Localization (localization) of TBP
1) Confidence 0.76 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.15 Pain Relevance 0
Total TBP localization to promoters seems to be a better index of promoter occupancy since normal and expanded polyQ TBP co-exists in the cell and may form heterodimers.
Localization (localization) of TBP
2) Confidence 0.76 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.06 Pain Relevance 0
Our results suggest a previously unknown mechanistic basis linking transcriptional dysregulation to cell death in neurodegeneration through TBP mediated alteration of Vdac1 expression.
Localization (alteration) of TBP associated with death
3) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.57 Pain Relevance 0
Besides, SCA17, caused by the expansion of polyQ tract in the TATA binding protein itself, normal TBP is also found in intra nuclear protein aggregates formed in other neurodegenerative diseases, notably, huntington's disease [8].
Localization (found) of SCA17 associated with disease and neurodegenerative disease
4) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.72 Pain Relevance 0
In addition, in all experiments, baseline EPSC amplitudes were small (mean 10 ± 3 pA, n = 12) to avoid suprathreshold summation of EPSPs during TBP (mean EPSP summation 6.1 ± 1.4 mV, mean resting potential ?
Localization (summation) of TBP
5) Confidence 0.35 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.37
We conclude that first, the reduction in TBP was due to the release of endogenous opioids caused by stress.
Localization (release) of TBP associated with stress and endogenous opioid
6) Confidence 0.32 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7768032 Disease Relevance 0.85 Pain Relevance 0.46
Accordingly, the values for B2MG, GUSB and POL2R were removed from the geNorm input file and the stability of GAPDH, HPRT, SDHA and TBP were re-assessed.
Localization (stability) of TBP
7) Confidence 0.05 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2823748 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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