INT52465

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 4.45
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
thyroid 2
medial 1
striatum 1
cleavage 1
Dio1 1
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 396 100.00 Very High Very High Very High
dopamine receptor 19 100.00 Very High Very High Very High
antagonist 17 100.00 Very High Very High Very High
substance P 100 99.96 Very High Very High Very High
agonist 28 99.82 Very High Very High Very High
projection neuron 191 99.80 Very High Very High Very High
narcan 3 99.30 Very High Very High Very High
Dynorphin 5 99.28 Very High Very High Very High
Cannabinoid 5 99.22 Very High Very High Very High
imagery 8 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 133 99.84 Very High Very High Very High
Catalepsy 9 99.66 Very High Very High Very High
Sprains And Strains 27 99.16 Very High Very High Very High
Urological Neuroanatomy 5 98.64 Very High Very High Very High
Neuroblastoma 94 98.34 Very High Very High Very High
Death 44 96.00 Very High Very High Very High
Skin Cancer 108 88.92 High High
Apoptosis 70 84.48 Quite High
Parkinson's Disease 53 82.16 Quite High
Dwarfism 52 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, these drug-induced catalepsies were due to the blockade of the D1 and D2 receptors, which was related to the analogous tertiary structures (diethylaminoethyl side chain).
Negative_regulation (blockade) of D1 associated with catalepsy
1) Confidence 0.58 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808703 Disease Relevance 0.46 Pain Relevance 0.14
D1 and D2 dopamine receptors were then down-regulated, relieving dopamine-predominant synaptic perturbation but leaving a defect in controlling dopamine responses.
Negative_regulation (down-regulated) of D1 associated with dopamine and dopamine receptor
2) Confidence 0.43 Published 2000 Journal Science Section Abstract Doc Link 10915629 Disease Relevance 0 Pain Relevance 0.24
It is interesting to note, however, that Dio1 (iodothyronine deiodinase), which is downregulated in most dwarf mouse strains and under CR (see Fig. 8), has been associated with positive selection and accelerated evolution within the mouse-chimp-human lineage (see supplemental data from [74]).
Negative_regulation (downregulated) of Dio1 in Dio1 associated with sprains and strains
3) Confidence 0.43 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.75 Pain Relevance 0
Indeed, D1 and D2 receptor as well as preproenkephalin A mRNA levels were decreased from G14 on, and dynorphin mRNA level was increased from G17 on.
Negative_regulation (decreased) of D1 associated with dynorphin
4) Confidence 0.41 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998124 Disease Relevance 0.07 Pain Relevance 0.70
Other key genes involved in postnatal growth via the somatotroph axis, including deiodinase 1 (DIO1), which activates thyroid hormone precursor, and the prolactin hormone receptor, were significantly reduced as well (Figure 4C).
Negative_regulation (reduced) of DIO1 in thyroid
5) Confidence 0.36 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.40 Pain Relevance 0
Other key genes involved in postnatal growth via the somatotroph axis, including deiodinase 1 (DIO1), which activates thyroid hormone precursor, and the prolactin hormone receptor, were significantly reduced as well (Figure 4C).
Negative_regulation (reduced) of deiodinase 1 in thyroid
6) Confidence 0.36 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.41 Pain Relevance 0
A mu-opioid receptor antagonist naloxone (0.03-1 mg/kg s.c.), and dopamine D1 and D2 receptor antagonists SCH 23390; R-(+)-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine HCl (0.01-0.1 mg/kg s.c.) and YM-09151-2 (nemonapride); cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4- methylaminobenzamide (0.003-0.1 mg/kg s.c.), respectively, dose dependently reduced the ambulation increase caused by morphine as well as the sensitization to morphine, when one of them was combined with morphine in the repeated administration.
Negative_regulation (reduced) of D1 associated with dopamine, antagonist, narcan, opioid receptor and morphine
7) Confidence 0.29 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7768292 Disease Relevance 0 Pain Relevance 1.30
Furthermore, a blockade of D1/D2 DA receptors was ineffective in preventing the locomotor stimulating action of (+)-MDMA.
Negative_regulation (blockade) of D1 associated with dopamine
8) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.15 Pain Relevance 0.61
Potentiation of endogenous cannabinoid signaling by the uptake blocker AM404 blocked dopamine D1 receptor-mediated grooming and D2 receptor-mediated oral stereotypies.
Negative_regulation (blocked) of D1 associated with dopamine and cannabinoid
9) Confidence 0.25 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17957223 Disease Relevance 0.06 Pain Relevance 0.99
A pre-incubation with the pan-caspase inhibitor z-VAD-FMK completely abolished the D1 and D6-induced caspases 3 and 7 cleavage activity, meaning that caspases are involved in this cell death.
Negative_regulation (abolished) of D1 in cleavage associated with death
10) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.80 Pain Relevance 0
Even in the neuroblastoma animal model, D6 induced a statistically significant more pronounced tumor growth reduction than D1 evaluated by means of BLI (Figure 6, panel C: D6 vs both D1 and control, P < 0.001).
Negative_regulation (reduction) of D1 associated with neuroblastoma, cancer and imagery
11) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.92 Pain Relevance 0.05
The effect of melatonin (1mg/kg, i.p.) was prevented by the pretreatment of mice with haloperidol (0.2mg/kg, i.p., a nonselective dopaminergic receptor antagonist), SCH23390 (0.05 mg/kg, s.c., a selective dopamine D1 receptor antagonist), and sulpiride (50mg/kg, i.p., a selective dopamine D2 receptor antagonist).
Negative_regulation (dopamine) of D1 associated with dopamine and antagonist
12) Confidence 0.22 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20406627 Disease Relevance 0 Pain Relevance 0.77
In contrast, the delta 2 agonist, DT-II, inhibited both D1 and A2a activated enzyme in all strains except DBA/2J, where DT-II did not inhibit D1-activated adenylyl cyclase.
Negative_regulation (inhibited) of D1 associated with agonist and sprains and strains
13) Confidence 0.19 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.33 Pain Relevance 0.79
M bicuculline, is completely different for each response: GABAA receptor blockade in D1-SP+ MSN (n?
Negative_regulation (blockade) of D1 associated with substance p
14) Confidence 0.07 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.65
Nonetheless, blockade of GABAA receptors during subthreshold responses decreases the synaptic potential in D1-SP+ MSNs since a depolarizing component: inhibition, was blocked (colored trace in Figure 3A).
Negative_regulation (decreases) of D1 associated with projection neuron and substance p
15) Confidence 0.07 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.51
For example, disruption of D1, D2, or D4 dopamine receptors in medial preoptic area impairs differing aspects of maternal care in rats [15].
Negative_regulation (disruption) of D1 in medial associated with dopamine receptor and urological neuroanatomy
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.10 Pain Relevance 0.65
D1 and D2 dopaminergic receptors are abundantly expressed in the cerebral cortex while D1, D2, D3, and D5 receptors are expressed in the striatum and D2, D3, and D5 receptors are expressed in the GPe.
Negative_regulation (receptors) of D1 in striatum associated with cerebral cortex
17) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0 Pain Relevance 0.36

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