INT52562

Context Info Confidence 0.00 First Reported 1995 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.09 Pain Relevance 1.02

extracellular region (Prl)

Anatomy Link Frequency pituitary 2 anterior pituitary 1 Lhb (Mus musculus) Prl (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 3 99.04 Sumatriptan 10 98.50 Somatostatin 1 82.00 Serotonin 2 75.00 agonist 1 41.88

Disease Link Frequency Relevance Heat Osteoporosis 2 96.48 Thyroid Disease 2 91.40 Hypopituitarism 4 85.72 Obesity 2 79.20 Growth Problems 2 73.84 Aplasia 2 66.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Combined provocative tests for pituitary hormones indicated blunted responses for GH, LH, FSH and a modest rise in serum PRL and TSH.

LH Positive_regulation (rise) of PRL in pituitary

1) Confidence 0.00 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9438923 Disease Relevance 0.48 Pain Relevance 0.10

Combined provocative tests for pituitary hormones indicated blunted responses for GH, LH, FSH and a modest rise in serum PRL and TSH.

LH Positive_regulation (rise) of PRL in pituitary

2) Confidence 0.00 Published 1998 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9699131 Disease Relevance 0.48 Pain Relevance 0.10

To assess the specificity of Sumatriptan on anterior pituitary hormone secretion, we studied its effect on TSH and PRL responses to TRH as well as LH-releasing hormone-induced LH and FSH secretion.

LH Positive_regulation (responses) of PRL in anterior pituitary associated with sumatriptan

3) Confidence 0.00 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.14 Pain Relevance 0.82

General Comments

This test has worked.