INT52653

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.17
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfc) extracellular space (Vegfc) extracellular region (Vegfc)
Anatomy Link Frequency
ventral root 1
spinal cord 1
Vegfc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 4 99.84 Very High Very High Very High
Nicotine 1 99.70 Very High Very High Very High
lidocaine 16 99.60 Very High Very High Very High
Spinal cord 26 98.80 Very High Very High Very High
antagonist 13 98.64 Very High Very High Very High
agonist 2 85.76 High High
isoflurane 6 84.96 Quite High
depression 5 79.68 Quite High
nMDA receptor 4 74.84 Quite High
narcan 4 72.32 Quite High
Disease Link Frequency Relevance Heat
Nociception 5 100.00 Very High Very High Very High
Shock 4 84.20 Quite High
Depression 5 79.68 Quite High
Pain 2 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At lidocaine concentrations of 1-10 micrograms/ml (3.6-36 microM), the slow-VRP was reduced from 79% to 36% of control.
Negative_regulation (reduced) of slow-VRP associated with lidocaine
1) Confidence 0.38 Published 1995 Journal Pain Section Abstract Doc Link 7784102 Disease Relevance 0.35 Pain Relevance 1.15
Low concentrations of lidocaine produced a selective reduction in the magnitude of the slow-VRP.
Negative_regulation (reduction) of slow-VRP associated with lidocaine
2) Confidence 0.38 Published 1995 Journal Pain Section Abstract Doc Link 7784102 Disease Relevance 0.35 Pain Relevance 1.08
In the presence of D-AP5 (20 microM) the area of the C-fibre evoked VRP was also significantly reduced.
Negative_regulation (reduced) of VRP associated with c fibre
3) Confidence 0.30 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902193 Disease Relevance 0.08 Pain Relevance 0.39
The simultaneous application of D-AP5 (20 microM) with either MEN,10376 (100 nM) or CP-96,345 (500 nM) together produced a reduction in the area of the evoked VRP which was comparable to the value obtained by addition of their individual effects.
Negative_regulation (reduction) of VRP
4) Confidence 0.22 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902193 Disease Relevance 0.06 Pain Relevance 0.34
The VRP duration was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of VRP
5) Confidence 0.19 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902193 Disease Relevance 0.07 Pain Relevance 0.39
The integrated area and duration of the high threshold evoked VRP were significantly reduced following superfusion of the spinal cord with the NK2 receptor antagonist MEN,10376 (100 nM).
Negative_regulation (reduced) of VRP in spinal cord associated with antagonist and spinal cord
6) Confidence 0.19 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902193 Disease Relevance 0.08 Pain Relevance 0.39
Both nicotine and muscarine depressed the nociceptive-related slow ventral root potential (sVRP).
Negative_regulation (depressed) of sVRP in ventral root associated with nociception and nicotine
7) Confidence 0.03 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12032014 Disease Relevance 0.17 Pain Relevance 0.55

General Comments

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