INT52819

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 7.22
Pain Relevance 5.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
facets 1
pituitary 1
eosinophils 1
mononuclear cells 1
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
Potency 1 99.58 Very High Very High Very High
Morphine 13 99.56 Very High Very High Very High
rheumatoid arthritis 30 99.34 Very High Very High Very High
Pain 85 99.32 Very High Very High Very High
Endogenous opioid 2 99.08 Very High Very High Very High
narcan 1 98.58 Very High Very High Very High
tolerance 7 97.32 Very High Very High Very High
Dopamine 12 96.56 Very High Very High Very High
Limbic system 1 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 135 99.58 Very High Very High Very High
Rheumatoid Arthritis 30 99.34 Very High Very High Very High
Pain 86 99.32 Very High Very High Very High
Chronic Fatigue Syndrome 7 98.96 Very High Very High Very High
Stress 17 98.82 Very High Very High Very High
Fibromyalgia 44 93.92 High High
Depression 38 88.80 High High
INFLAMMATION 229 86.96 High High
Birth Weight 1 84.96 Quite High
Pre-term Labor 1 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such tests are more sensitive as they assess facets of the HPA axis which are considered to be primary causal factors, namely dysregulation of hypothalamic drive (Holsboer 2002) and reduced glucocorticoid receptor (GR) feedback (McQuade and Young 2000; Pariante and Miller 2001).
Negative_regulation (reduced) of glucocorticoid receptor in facets
1) Confidence 0.50 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.53 Pain Relevance 0.13
Prevention of the GR upregulation with GR antisense oligonucleotides as well as inhibition of GR activation with the GR antagonist RU38486 effectively prevented the exacerbated morphine tolerance after subsequent cycles of morphine exposure.
Negative_regulation (Prevention) of GR associated with antagonist, tolerance and morphine
2) Confidence 0.42 Published 2005 Journal Pain Section Abstract Doc Link 15733634 Disease Relevance 0 Pain Relevance 2.20
Polymorphisms in NR3C1 have previously been associated with CFS31 and shown to distinguish between different classes of CFS.32
Negative_regulation (Polymorphisms) of NR3C1 associated with chronic fatigue syndrome
3) Confidence 0.17 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2927682 Disease Relevance 1.54 Pain Relevance 0.51
(r = -0.68) and with the number of activated alveolar eosinophils (EG2+, r = 0.66).[18] In this same group of patients, NA was associated with reduced glucocorticoid receptor (GR)-binding affinity, reduced proliferation of peripheral blood mononuclear cells and decreased responsiveness to steroids when compared to NNA patients.[29] Those studies have demonstrated that the increased numbers of CD4+ cells in alveolar tissue in NA patients, as well as reduced GR-binding affinity and reduced steroid responsiveness, may be responsible for orchestrating eosinophil influx and exacerbations of symptoms in patients with NA.
Negative_regulation (reduced) of glucocorticoid receptor in eosinophils associated with asthma
4) Confidence 0.14 Published 2007 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2732069 Disease Relevance 1.23 Pain Relevance 0.03
In patients with rheumatoid arthritis (RA) with a mean duration of six years, glucocorticoid receptor (GR) downregulation has been reported without change in cortisol levels.
Negative_regulation (downregulation) of glucocorticoid receptor associated with rheumatoid arthritis
5) Confidence 0.09 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114259 Disease Relevance 0.67 Pain Relevance 0.30
Glucocorticoid receptor downregulation in early diagnosed rheumatoid arthritis.
Negative_regulation (downregulation) of Glucocorticoid receptor associated with rheumatoid arthritis
6) Confidence 0.09 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 12114259 Disease Relevance 0.89 Pain Relevance 0.45
Role of endogenous opioid peptides in central glucocorticoid receptor (GR)-induced decreases in circulating LH in the male rat.
Negative_regulation (decreases) of GR associated with narcan and endogenous opioid
7) Confidence 0.08 Published 1995 Journal Neuropeptides Section Title Doc Link 7791961 Disease Relevance 0.05 Pain Relevance 0.43
This complex serves as the “active signal” that induces transcriptional alterations suppressing the mRNA of the glucocorticoid receptor (Rm) which drives downstream the reduced cytosolic receptor density.
Negative_regulation (suppressing) of glucocorticoid receptor
8) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.20 Pain Relevance 0.38
In the rat, gestational stress and excess maternal and fetal plasma corticosterone cause downregulation of fetal glucocorticoid (GR) and mineralocorticoid (MR) receptors and impair the feedback regulation of the hypothalamic-pituitary adrenal (HPA) axis in infancy and adulthood.
Negative_regulation (downregulation) of glucocorticoid in pituitary associated with stress
9) Confidence 0.07 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15944068 Disease Relevance 0.68 Pain Relevance 0.20
In this same cohort of patients, NA was associated with reduced glucocorticoid receptor (GR)-binding affinity (indicated by an increased Kd), reduced proliferation of peripheral blood mononuclear cells and decreased responsiveness to steroids at 4.00 a.m. compared with NNA patients [48].
Negative_regulation (reduced) of glucocorticoid receptor in mononuclear cells associated with asthma
10) Confidence 0.06 Published 2001 Journal Respir Res Section Body Doc Link PMC64806 Disease Relevance 0.88 Pain Relevance 0.03
Long-term treatment of the cell cultures with RU 39305, a selective antagonist of glucocorticoid receptors (GR), but not with spironolactone, a selective antagonist of mineralocorticoid receptors (MR), dose-dependently decreased K+-stimulated dopamine release.
Negative_regulation (antagonist) of GR associated with dopamine and antagonist
11) Confidence 0.05 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10383623 Disease Relevance 0 Pain Relevance 0.87
Its binding and antagonist potency with respect to the glucocorticoid receptor is significantly reduced compared to that of mifepristone, indicating that UPA belongs to a new type of dissociated progesterone receptor modulators that have reduced antiglucorticoid activity.13,15–17 The chemical structure of progesterone, LNG and UPA is depicted in Figure 1.
Negative_regulation (reduced) of glucocorticoid receptor associated with antagonist and potency
12) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0.11 Pain Relevance 0.10
By reviewing the literature on the human glucocorticoid receptor ?
Negative_regulation (reviewing) of glucocorticoid receptor
13) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: In patients with rheumatoid arthritis (RA) of longer duration, glucocorticoid receptor (GR) down-regulation has been reported without any change in cortisol levels.
Negative_regulation (regulation) of glucocorticoid receptor associated with rheumatoid arthritis
14) Confidence 0.02 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12175100 Disease Relevance 0.36 Pain Relevance 0.22

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