INT52839

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Context Info
Confidence 0.25
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 9.46
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
neuronal 2
spinal cord 1
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 3 99.70 Very High Very High Very High
ischemia 172 99.48 Very High Very High Very High
MU agonist 2 99.36 Very High Very High Very High
agonist 9 99.20 Very High Very High Very High
antagonist 15 98.88 Very High Very High Very High
Spinal cord 132 97.84 Very High Very High Very High
narcan 6 96.72 Very High Very High Very High
opioid receptor 6 93.64 High High
Opioid 4 89.56 High High
Potency 2 88.80 High High
Disease Link Frequency Relevance Heat
Apoptosis 74 100.00 Very High Very High Very High
Pancreatic Cancer 22 100.00 Very High Very High Very High
Cv General 4 Under Development 110 99.48 Very High Very High Very High
Inflammatory Breast Neoplasms 120 99.40 Very High Very High Very High
Adenocarcinoma 157 98.26 Very High Very High Very High
Spinal Cord Injury 66 98.12 Very High Very High Very High
Cognitive Disorder 24 97.96 Very High Very High Very High
Cv Unclassified Under Development 60 97.80 Very High Very High Very High
Reperfusion Injury 12 97.44 Very High Very High Very High
Cancer 314 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bicuculline, antagonist of a receptor not linked to G proteins, GABAA, did not alter the effect of mastoparan on the GTPase.
Regulation (effect) of GTPase associated with antagonist
1) Confidence 0.25 Published 1995 Journal Cell. Signal. Section Abstract Doc Link 7794687 Disease Relevance 0.15 Pain Relevance 0.73
Bicuculline, antagonist of a receptor not linked to G proteins, GABAA, did not alter the effect of mastoparan on the GTPase.
Neg (not) Regulation (alter) of GTPase associated with antagonist
2) Confidence 0.25 Published 1995 Journal Cell. Signal. Section Abstract Doc Link 7794687 Disease Relevance 0.15 Pain Relevance 0.73
Myr+-Gi2 alpha subunits pre-incubated with GTPgammaS or GDPbetaS before i.c.v. injection did not improve the activity of agonists in vivo (antinociception) or in vitro (regulation of low Km GTPase).
Regulation (regulation) of Km GTPase associated with antinociception and agonist
3) Confidence 0.06 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10608281 Disease Relevance 0.20 Pain Relevance 0.96
Regulator of G Protein Signaling 2 (RGS2), a GTPase-activating protein of the G?
Regulation (Regulator) of GTPase
4) Confidence 0.06 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2650719 Disease Relevance 0.60 Pain Relevance 0
Studies that target Rac1 GTPase for inhibition may thus have efficacy in preservation of neuronal survival and cognitive function following stroke in humans, and therefore should be further explored.



Regulation (target) of GTPase in neuronal associated with cognitive disorder and stroke
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.43 Pain Relevance 0.24
In addition, the current study revealed that neuronal degeneration in the hippocampal CA1 region was also markedly inhibited by the pretreatment of the Rac GTPase inhibitor following GCI, suggesting an important role of Rac GTPase activation in delayed neuronal degeneration following ischemia/reperfusion injury.
Regulation (role) of Rac GTPase in neuronal associated with reperfusion injury and ischemia
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.21 Pain Relevance 0.29
Two genes, RhoC GTPase and a novel gene, were found to be concordantly altered in 91% of the IBC specimens versus 0% of the stage-matched non-IBC tumors.
Regulation (altered) of GTPase associated with inflammatory breast neoplasms and cancer
7) Confidence 0.02 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.50 Pain Relevance 0.07
Of the five missense mutations, one (G127V) affects the GTPase domain, and two mutations change the region linking the GTPase domain and the first coiled coil region (E347V and M376I).
Regulation (affects) of GTPase
8) Confidence 0.01 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1524942 Disease Relevance 0.06 Pain Relevance 0
RT-PCR of RhoC expression in PC cell lines was performed as previously described [54] using primers specific for RhoC GTPase and GAPDH control.
Regulation (control) of GTPase associated with adenocarcinoma
9) Confidence 0.01 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1

Background

Regulation (Regulation) of GTPase associated with pancreatic cancer
10) Confidence 0.01 Published 2005 Journal Mol Cancer Section Title Doc Link PMC1173138 Disease Relevance 0.94 Pain Relevance 0
In this study we identified Rho GTPase activity as a critical regulator of cell survival in the paradigm of NSPC transplantation into the rodent spinal cord.
Regulation (regulator) of GTPase in spinal cord associated with spinal cord
11) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.41 Pain Relevance 0.27
Regulation of programmed cell death in vitro by manipulating Rho GTPase activity
Regulation (Regulation) of GTPase associated with apoptosis
12) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.32 Pain Relevance 0.03
This type of intramolecular FRET sensor can be expressed in living cells with negligible perturbation of endogenous protein function [67, 68], and permits monitoring of the subcellular “microenvironment” that regulates GTPase activities in living cells.
Regulation (regulates) of GTPase
13) Confidence 0.01 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.09 Pain Relevance 0.04
When expressed it is a GTP-binding protein located on the cytoplasmic aspect of the cell membrane and has intrinsic GTPase activity that is regulated by other proteins [73].
Regulation (regulated) of GTPase
14) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.20 Pain Relevance 0
Here we present evidence for the involvement of RhoC GTPase and p38 MAPK in the migratory and invasive phenotype after loss of cav-1 expression in PC cells.
Regulation (involvement) of GTPase associated with adenocarcinoma
15) Confidence 0.00 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.04 Pain Relevance 0

General Comments

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