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Context Info
Confidence 0.46
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 19.04
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A)
nucleus (TNFRSF1A) protein complex (TNFRSF1A)
Anatomy Link Frequency
plasma 3
cerebrospinal fluid 2
immune cells 1
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 99.92 Very High Very High Very High
opiate 9 98.88 Very High Very High Very High
cytokine 108 98.80 Very High Very High Very High
opioid receptor 4 98.52 Very High Very High Very High
Inflammation 238 98.26 Very High Very High Very High
Multiple sclerosis 8 97.24 Very High Very High Very High
intrathecal 2 96.96 Very High Very High Very High
cINOD 8 92.84 High High
corticosteroid 12 90.88 High High
IPN 1 89.08 High High
Disease Link Frequency Relevance Heat
Cancer 42 100.00 Very High Very High Very High
Necrosis 36 100.00 Very High Very High Very High
Encephalopathy 25 100.00 Very High Very High Very High
Fever 16 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 6 99.80 Very High Very High Very High
Synovitis 45 99.48 Very High Very High Very High
Familial Mediterranean Fever 5 99.46 Very High Very High Very High
Pulmonary Disease 190 99.04 Very High Very High Very High
Syndrome 41 98.64 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 24 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional induction of the gene in immune cells was mediated via tumor necrosis factor receptor type 2.
Positive_regulation (induction) of tumor necrosis factor receptor type 2 in immune cells associated with necrosis and cancer
1) Confidence 0.46 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14500744 Disease Relevance 0.86 Pain Relevance 0.50
upregulation of some genes, such as TNFR-1 and TNFR-2, TRAF-6 and IGFBP-6, whose transcription is under the control of NF-?
Positive_regulation (upregulation) of TNFR-1
2) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
The genes responsible for all these autoinflammatory HPFS have been identified, and include MEFV (encoding pyrin) responsible for FMF, TNFRSF1A for TRAPS, mevalonate kinase for HIDS, CIAS1/NLRP3 for CAPS, and the PSTPIP1 gene responsible for PAPA syndrome.
Positive_regulation (include) of TNFRSF1A associated with syndrome, tumor necrosis factor receptor-associated periodic syndrome, acne, familial mediterranean fever and fever
3) Confidence 0.37 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948378 Disease Relevance 3.51 Pain Relevance 0.23
Increased levels of tumor necrosis factor-alpha messenger RNA were not associated with increased levels of IL-1 beta messenger RNA, suggesting differential regulation of these monokines in acquired immunodeficiency syndrome dementia.
Positive_regulation (Increased) of tumor necrosis factor-alpha messenger RNA associated with necrosis, dementia, syndrome, cancer and immunodeficiency
4) Confidence 0.37 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8498837 Disease Relevance 1.73 Pain Relevance 0.23
Sulindac sulfide specifically up-regulated the DR5 levels but had no effect on the levels of other DRs including DR4, Fas, and tumor necrosis factor receptor 1.
Neg (no) Positive_regulation (effect) of tumor necrosis factor receptor 1 associated with necrosis and cancer
5) Confidence 0.30 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 1.78 Pain Relevance 0.07
High levels of sTNF-R were found in CSF of patients with HTLV-I-associated myelopathy and multiple sclerosis.
Positive_regulation (levels) of sTNF-R in CSF associated with spinal cord diseases and multiple sclerosis
6) Confidence 0.27 Published 1995 Journal J. Neurol. Section Abstract Doc Link 7798123 Disease Relevance 1.19 Pain Relevance 0.36
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.
Positive_regulation (activation) of tumor necrosis factor alpha promoter associated with necrosis, inflammation and cancer
7) Confidence 0.20 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 14645256 Disease Relevance 0.83 Pain Relevance 0.23
These values were correlated with drug use and neurocognitive function. sTNF-R2 was significantly up-regulated in those patients who used opiates compared to those who did not.
Positive_regulation (up-regulated) of sTNF-R2 associated with opiate
8) Confidence 0.13 Published 2004 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 15000697 Disease Relevance 0.73 Pain Relevance 0.26
Previously, we reported an increase in soluble tumor necrosis factor-alpha receptor two (sTNF-R2) and soluble CD14 (sCD14) in the plasma of HIV-seropositive individuals with neurocognitive dysfunction compared to their cognitively intact counterparts.
Positive_regulation (increase) of sTNF-R2 in plasma associated with necrosis, cancer and acquired immune deficiency syndrome or hiv infection
9) Confidence 0.13 Published 2004 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 15000697 Disease Relevance 0.74 Pain Relevance 0.13
Previously, we reported an increase in soluble tumor necrosis factor-alpha receptor two (sTNF-R2) and soluble CD14 (sCD14) in the plasma of HIV-seropositive individuals with neurocognitive dysfunction compared to their cognitively intact counterparts.
Positive_regulation (increase) of tumor necrosis factor-alpha receptor in plasma associated with necrosis, cancer and acquired immune deficiency syndrome or hiv infection
10) Confidence 0.13 Published 2004 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 15000697 Disease Relevance 0.74 Pain Relevance 0.07
In narcoleptic patients, soluble TNF receptor (sTNF-R) p75 plasma levels have been shown to be elevated, suggesting a functional role of the TNF-?
Positive_regulation (elevated) of sTNF-R in plasma
11) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Abstract Doc Link PMC2687935 Disease Relevance 0.53 Pain Relevance 0.12
Cytokine levels in serum and cerebrospinal fluid (CSF) are markedly increased in the majority of severe IAEE cases, especially levels of interleukin (IL)-6, IL-10 and soluble tumor necrosis factor receptor 1.
Positive_regulation (increased) of tumor necrosis factor receptor 1 in cerebrospinal fluid associated with necrosis, cancer, encephalopathy and cytokine
12) Confidence 0.04 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2474850 Disease Relevance 1.78 Pain Relevance 0.34
Changes in RI can also be induced by increasing probe pressure and by changes in temperature.
Positive_regulation (induced) of RI
13) Confidence 0.03 Published 2007 Journal Skeletal Radiol Section Body Doc Link PMC2141652 Disease Relevance 0.17 Pain Relevance 0
In diabetes associated with diabetic microangiopathy, compared with non diabetics, asymmetric dimethylarginine [ADMA]; an endogenous inhibitor of NOS, serum TNF-alpha and soluble TNF receptor I (sTNFR-I) has been assessed in a study which concludes that the serum sTNFR-I and VEGF levels were significantly increased, but no difference in the serum TNF-alpha, sTNFR-II, and ADMA levels between uncomplicated diabetic patients and in non diabetics (Makino et al 2005).
Positive_regulation (increased) of sTNFR-I associated with diabetic angiopathy and diabetes mellitus
14) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.46 Pain Relevance 0.20
Small but significant increases in circulating levels of both the soluble TNF receptors 55 and 75 (sTNF-R55 and sTNF-R75) [18], IL-10 [19] and IL-18 [20] have also been reported in such patients.
Positive_regulation (increases) of sTNF-R55
15) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.77 Pain Relevance 0.28
Indeed, Dentener et al. [14] documented that levels of the anti-inflammatory mediator-soluble interleukin 1 receptor II (sIL-1RII) were similar in patients with stable COPD compared to healthy subjects, despite markedly increased sTNF-R55.
Positive_regulation (increased) of sTNF-R55 associated with pulmonary disease and inflammation
16) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.24 Pain Relevance 0.33

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