INT52919

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Latest revision as of 22:59, 22 September 2012

Context Info
Confidence 0.42
First Reported 1995
Last Reported 2005
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.86
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkca) mitochondrion (Prkca) aging (Prkca)
endoplasmic reticulum (Prkca) plasma membrane (Prkca) nucleus (Prkca)
Anatomy Link Frequency
brain 2
nucleus 2
Prkca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 30 100.00 Very High Very High Very High
narcan 14 99.82 Very High Very High Very High
Clonidine 2 97.30 Very High Very High Very High
agonist 9 96.96 Very High Very High Very High
Morphine 34 96.24 Very High Very High Very High
withdrawal 21 95.88 Very High Very High Very High
methadone 3 92.64 High High
fortral 4 91.80 High High
medulla 6 89.56 High High
Opioid 2 87.52 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 92.00 High High
Toxocariasis 10 89.04 High High
Attention Deficit Hyperactivity Disorder 2 87.16 High High
Overdose 2 81.44 Quite High
Opiate Addiction 3 76.64 Quite High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute (10 mg/kg for 2 h) and chronic (2x10 mg/kg for 5 and 14 days) treatment with naloxone did not alter PKC-alphabeta immunoreactivity.
Neg (not) Regulation (alter) of PKC-alphabeta associated with narcan
1) Confidence 0.42 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9109366 Disease Relevance 0 Pain Relevance 1.71
In this context, chronic treatment of rats with other inhibitory agonists (e.g., clonidine, 1 mg/kg i.p. every 12 h for 14 days) acting through receptors (e.g., alpha 2-adrenoceptors) also coupled to adenylyl cyclase did not alter brain PKC-alpha beta immunoreactivity.
Neg (not) Regulation (alter) of PKC-alpha beta in brain associated with kinase c, agonist and clonidine
2) Confidence 0.32 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798919 Disease Relevance 0.06 Pain Relevance 0.99
Chronic treatment with naloxone (1 mg/kg i.p. every 12 h for 5 days) did not alter PKC-alpha beta immunoreactivity in the rat brain.
Neg (not) Regulation (alter) of PKC-alpha beta in brain associated with kinase c and narcan
3) Confidence 0.32 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798919 Disease Relevance 0.33 Pain Relevance 1.22
The present study was designed to investigate the role of protein kinase C (PKC) in this process by estimating changes in PKCalpha and PKCgamma immunoreactivity, and whether pharmacological inhibition of PKC would attenuate morphine withdrawal-induced c-Fos expression and changes in tyrosine hydroxylase (TH) immunoreactivity levels in the PVN and nucleus tractus solitarius/ ventrolateral medulla (NTS/VLM).
Regulation (changes) of PKCalpha in nucleus associated with medulla, kinase c, toxocariasis, withdrawal and morphine
4) Confidence 0.09 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.23 Pain Relevance 1.12
The present study was designed to investigate the role of protein kinase C (PKC) in this process by estimating changes in PKCalpha and PKCgamma immunoreactivity, and whether pharmacological inhibition of PKC would attenuate morphine withdrawal-induced c-Fos expression and changes in tyrosine hydroxylase (TH) immunoreactivity levels in the PVN and nucleus tractus solitarius/ ventrolateral medulla (NTS/VLM).
Regulation (changes) of PKCalpha in PVN associated with medulla, kinase c, toxocariasis, withdrawal and morphine
5) Confidence 0.03 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.23 Pain Relevance 1.12

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