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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 10.80
Pain Relevance 7.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
Plasma 3
lateral 1
brainstem 1
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 225 100.00 Very High Very High Very High
agonist 133 100.00 Very High Very High Very High
cytokine 97 100.00 Very High Very High Very High
Pain 28 99.84 Very High Very High Very High
Neuropeptide 8 99.84 Very High Very High Very High
Arthritis 72 99.72 Very High Very High Very High
imagery 6 99.60 Very High Very High Very High
cINOD 8 99.44 Very High Very High Very High
Eae 11 98.28 Very High Very High Very High
Neuropathic pain 14 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 245 100.00 Very High Very High Very High
Cancer 36 100.00 Very High Very High Very High
Necrosis 30 100.00 Very High Very High Very High
Nociception 20 99.84 Very High Very High Very High
Arthritis 50 99.72 Very High Very High Very High
Disease Progression 1 99.40 Very High Very High Very High
Injury 71 99.36 Very High Very High Very High
Pancreatitis 47 99.12 Very High Very High Very High
Neuropathic Pain 24 98.20 Very High Very High Very High
Stress 21 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the effect of centrally injected IL-1 alpha on immunocyte BE concentrations in the rat.
Regulation (effect) of IL-1 alpha
1) Confidence 0.44 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925095 Disease Relevance 0.19 Pain Relevance 0.33
Central effects of tumor necrosis factor alpha and interleukin-1 alpha on nociceptive thresholds and spontaneous locomotor activity.
Regulation (effects) of interleukin-1 alpha associated with nociception, pain, necrosis, cancer and eae
2) Confidence 0.37 Published 1992 Journal Neurosci. Lett. Section Title Doc Link 1300507 Disease Relevance 1.36 Pain Relevance 0.69
To extend the knowledge on the central effects of cytokines, we studied the effects of tumor necrosis factor alpha and interleukin-1 alpha on nociceptive thresholds and spontaneous locomotor activity in rats.
Regulation (effects) of interleukin-1 alpha associated with nociception, necrosis, cancer, eae and cytokine
3) Confidence 0.37 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1300507 Disease Relevance 1.15 Pain Relevance 0.42
To assess the effect of interleukin-1 (IL-1) in the brain on nociception electrophysiologically, recombinant human IL-1 beta (rhIL-1 beta) (1 pg/kg to 1 microgram/kg, i.e., 0.29 pg-0.33 microgram/rat) was microinjected into the lateral cerebral ventricle of urethane-anesthetized rats and the changes of responses in the wide dynamic range (WDR) neurons in the trigeminal nucleus caudalis to noxious pinching of facial skin were observed.
Regulation (effect) of IL-1 in lateral associated with nociception and wide dynamic range
4) Confidence 0.35 Published 1994 Journal Brain Res. Section Abstract Doc Link 7820583 Disease Relevance 0.17 Pain Relevance 0.16
This effect on interleukin-1 was not observed when the drugs were dosed one hour after injury.


Regulation (effect) of interleukin-1 associated with injury
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2930858 Disease Relevance 0.73 Pain Relevance 0.03
A model for the study of experimentally induced temporomandibular arthritis in rats: the effect of human recombinant interleukin-1 alpha on neuropeptide-like immunoreactivity.
Regulation (effect) of recombinant interleukin-1 alpha associated with neuropeptide and arthritis
6) Confidence 0.26 Published 1996 Journal J Orofac Pain Section Title Doc Link 8995911 Disease Relevance 0.33 Pain Relevance 0.76
Similarly to other lipoxygenase inhibitors and hydroxyl radical scavenger NSAIDs, melanin treatment did not affect IL-1 neither increased the splenic mitogenic responses, unlike the classical cyclooxygenase inhibitory NSAIDs.
Neg (not) Regulation (affect) of IL-1 associated with cinod
7) Confidence 0.18 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9706378 Disease Relevance 0.99 Pain Relevance 0.44
No change in IL-1?
Neg (No) Regulation (change) of IL-1
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2930858 Disease Relevance 0.57 Pain Relevance 0
Several of the identified proteins, including fatty acid binding protein-brain (FABP-B), major histocompatibility complex (MHC) class 1, T-cell receptor (TCR) alpha chain, and interleukin-1 (IL-1), showed significantly higher levels in the NP rat brainstem.
Regulation (Several) of IL-1 in brainstem associated with medulla and neuropathic pain
9) Confidence 0.17 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15363894 Disease Relevance 0.63 Pain Relevance 0.94
A large number of inflammatory factors, such as IL-1 and TNF?
Regulation (number) of IL-1 associated with inflammation
10) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.70 Pain Relevance 0.33
Effect of RAR-selective agonists on IL-1-induced expression of IL-6
Regulation (Effect) of IL-1 associated with agonist
11) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.05 Pain Relevance 0.42
in rats is about 40 min [49], it is unlikely that a down-regulation of the existing IL-1?
Regulation (regulation) of IL-1
12) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.87 Pain Relevance 0.66
MAP kinases in the peripheral tissues play a critical role in innate immunity and host defense by regulation of cytokines such as IL-1, IL-6, and TNF?
Regulation (regulation) of IL-1 associated with cytokine
13) Confidence 0.06 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.78 Pain Relevance 0.82
Effect of retinoids on IL-1?
Regulation (Effect) of IL-1
14) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.08 Pain Relevance 0.10
Resveratrol did not affect lipase activity, concentrations of IL-1ß and IL-10 in the plasma as well as pancreatic DNA synthesis.
Neg (not) Regulation (affect) of IL-1 in plasma
15) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 1.16 Pain Relevance 0.06
The effects of berberine chloride on the mRNA of IL-1?
Regulation (effects) of IL-1
16) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.06 Pain Relevance 0.11
Plasma samples were analysed for tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interferon-gamma, interleukin-10 and the interleukin-1 receptor antagonist.
Spec (analysed) Regulation (analysed) of interleukin-1 alpha in Plasma associated with necrosis, cancer and antagonist
17) Confidence 0.02 Published 1998 Journal Eur J Anaesthesiol Section Abstract Doc Link 9522142 Disease Relevance 0.36 Pain Relevance 0.45
No significant changes in IL-1?
Neg (No) Regulation (changes) of IL-1
18) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0 Pain Relevance 0.35
Plasma concentrations of interleukin-1 alpha, interleukin-1 beta, interleukin-2, interleukin-6, tumor necrosis factor-alpha, and plasma levels of C-reactive protein, cortisol, and zinc were analyzed.
Regulation (concentrations) of interleukin-1 alpha in Plasma associated with necrosis and cancer
19) Confidence 0.01 Published 1996 Journal Med Sci Sports Exerc Section Abstract Doc Link 8871903 Disease Relevance 0.62 Pain Relevance 0.24

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