INT53188

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VSX1) cellular_component (VSX1)
Anatomy Link Frequency
spinal cord 2
brain 2
dorsal horn 2
VSX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 10 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
Dorsal horn 2 99.84 Very High Very High Very High
Spinal cord 3 98.64 Very High Very High Very High
Inflammation 14 95.24 Very High Very High Very High
Dynorphin 5 88.40 High High
antagonist 1 77.56 Quite High
Hyperalgesia 3 75.00 Quite High
electroacupuncture 2 75.00 Quite High
Pain 2 74.56 Quite High
Disease Link Frequency Relevance Heat
Periodontitis 14 99.98 Very High Very High Very High
INFLAMMATION 9 95.24 Very High Very High Very High
Hypersensitivity 1 92.16 High High
Chronic Periodontitis 3 90.56 High High
Nicotine Addiction 15 81.52 Quite High
Hyperalgesia 4 75.00 Quite High
Clinical Trials And Case Reports 2 52.72 Quite High
Pain 3 50.96 Quite High
Disease 4 5.00 Very Low Very Low Very Low
Periodontal Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of short- and long-term cocaine exposure on the expression of the nuclear transcription factor genes, c-fos and zif/268, as well as the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in various regions of rat brain were evaluated by injecting i.p. saline or 10, 20, or 30 mg/kg cocaine HCl once daily for 1 or 10 days.
Regulation (effects) of Gene_expression (expression) of PPD in brain associated with opioid and cocaine
1) Confidence 0.40 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.37
PPD mRNA expression was not altered on the contralateral side of the spinal cord in any group.
Neg (not) Regulation (altered) of Gene_expression (expression) of PPD mRNA in spinal cord associated with spinal cord
2) Confidence 0.32 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.33 Pain Relevance 0.77
It is interesting to note that the diagnosis of aggressive periodontitis affected RAL-V gains but not PPD reduction.
Neg (not) Regulation (affected) of Gene_expression (reduction) of PPD associated with periodontitis
3) Confidence 0.25 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.73 Pain Relevance 0
These results suggest the role of DREAM in the dorsal horn in the regulation of PPD gene expression by EAS is frequency dependent, and DREAM may exert different roles in different frequency EAS under physiological and inflammatory conditions.
Regulation (regulation) of Gene_expression (expression) of PPD gene in dorsal horn associated with inflammation and dorsal horn
4) Confidence 0.06 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18404375 Disease Relevance 0.35 Pain Relevance 0.52

General Comments

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