INT53449

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.80
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PPL) plasma membrane (PPL) cytoskeleton (PPL)
nucleus (PPL) cytoplasm (PPL)
Anatomy Link Frequency
thorax 1
lung 1
kidney 1
PPL (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 10 100.00 Very High Very High Very High
agonist 8 98.28 Very High Very High Very High
Central nervous system 2 95.36 Very High Very High Very High
Bile 3 84.32 Quite High
opioid receptor 4 79.92 Quite High
mu opioid receptor 2 75.00 Quite High
Pain 3 62.44 Quite High
depression 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 59 100.00 Very High Very High Very High
Bullous Skin Disease 18 100.00 Very High Very High Very High
Polycystic Kidney Disease 4 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 84 98.16 Very High Very High Very High
Cystadenoma 1 90.00 High High
Cystadenocarcinoma 1 88.72 High High
Malignant Neoplastic Disease 1 83.16 Quite High
Necrosis 2 82.48 Quite High
Acantholysis 2 81.48 Quite High
Death 1 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-expression of periplakin with MOP-1 or a MOP-1-eYFP fusion construct in HEK293 cells did not interfere with agonist-mediated internalization of the receptor.
Gene_expression (Co-expression) of periplakin associated with agonist and opioid
1) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12810704 Disease Relevance 0 Pain Relevance 0.73
When co-expressed with a MOP-1-Gi1 alpha fusion protein periplakin significantly reduced the capacity of the agonist to stimulate binding of 35S-labeled guanosine 5'-3-O-(thio)triphosphate ([35S]GTP gamma S) to the receptor-associated G protein.
Gene_expression (co-expressed) of periplakin associated with agonist and opioid
2) Confidence 0.65 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12810704 Disease Relevance 0 Pain Relevance 0.79
Periplakin, a member of the plakin family of proteins, has been recently characterized by complementary deoxyribonucleic acid (cDNA) cloning, and the corresponding gene,…
Gene_expression (member) of Periplakin
3) Confidence 0.65 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2859134 Disease Relevance 0 Pain Relevance 0
We have examined for any possible association between polycystic kidney disease and PPL, given the existence of both conditions in case two.
Gene_expression (disease) of PPL in kidney associated with lymphatic system cancer and polycystic kidney disease
4) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475874 Disease Relevance 1.32 Pain Relevance 0.04
Thus, estimating Ppc by measuring Ppl on any surface within the thorax may still underestimate actual Ppc, which is LV surrounding pressure [10].
Gene_expression (measuring) of Ppl in thorax
5) Confidence 0.19 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.24 Pain Relevance 0
A decrease in lung compliance has been shown to decrease the transmission of Paw to intrathoracic structures (commonly measured as Ppl) [19,20], while these findings have been challenged by O'Quin and Marini [17], who measured juxtacardiac Ppl and found that the fractional change of Ppl versus Paw was only slightly decreased after acute lung injury in a canine model.
Gene_expression (change) of Ppl in lung associated with adult respiratory distress syndrome
6) Confidence 0.19 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.16 Pain Relevance 0
This method is the most convenient and cost-effective method of screening for PP, since antigens of both pemphigus vulgaris and pemphigus foliaceus are not expressed in this tissue.
Neg (not) Gene_expression (expressed) of pemphigus associated with bullous skin disease
7) Confidence 0.08 Published 1994 Journal Hautarzt Section Abstract Doc Link 7843961 Disease Relevance 1.05 Pain Relevance 0.06
This method is the most convenient and cost-effective method of screening for PP, since antigens of both pemphigus vulgaris and pemphigus foliaceus are not expressed in this tissue.
Neg (not) Gene_expression (expressed) of pemphigus associated with bullous skin disease
8) Confidence 0.08 Published 1994 Journal Hautarzt Section Abstract Doc Link 7843961 Disease Relevance 1.04 Pain Relevance 0.06

General Comments

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