INT5358

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
neurons 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 16 100.00 Very High Very High Very High
Glutamate 10 96.04 Very High Very High Very High
Lamotrigine 1 91.76 High High
Gabapentin 1 91.24 High High
anticonvulsant 2 90.60 High High
headache 23 89.32 High High
Cluster headache 6 86.64 High High
GABAergic 1 85.12 High High
Migraine 57 83.36 Quite High
Pain 36 80.12 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 98.36 Very High Very High Very High
Headache 77 89.32 High High
Cluster Headache 6 86.64 High High
Body Weight 1 84.60 Quite High
Complex Regional Pain Syndromes 1 80.48 Quite High
Neurogenic Inflammation 8 76.84 Quite High
Pain 33 75.00 Quite High
Vomiting 7 67.16 Quite High
Nociception 17 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes manifested themselves in activation of GABA degradation with simultaneous rise of the succinate--but not isocitrate dehydrogenase activity, inhibition of glutamate dehydrogenase activity and worsening of blood supply to neurons.
Positive_regulation (activation) of Protein_catabolism (degradation) of GABA in neurons associated with glutamate and gaba
1) Confidence 0.38 Published 1992 Journal Patol Fiziol Eksp Ter Section Abstract Doc Link 1303507 Disease Relevance 0.41 Pain Relevance 0.49
Valproate is provided with two mechanisms of action, being able to inhibit GABA-transaminase, which causes GABA degradation and, at the same time, to activate glutamic - decarboxylase, that induces GABA synthesis.
Positive_regulation (causes) of Protein_catabolism (degradation) of GABA associated with gaba
2) Confidence 0.05 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2771268 Disease Relevance 0.87 Pain Relevance 1.40

General Comments

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