INT53683

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 9.11
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
neutrophil 4
granulocytes 3
plasma 2
lymphocytes 2
monocytes 1
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 7 99.34 Very High Very High Very High
reflex sympathetic dystrophy 7 98.04 Very High Very High Very High
Inflammation 68 97.76 Very High Very High Very High
cytokine 16 95.04 Very High Very High Very High
Neuritis 4 89.28 High High
Pain 3 87.72 High High
opiate 4 87.04 High High
methadone 3 86.04 High High
Multiple sclerosis 1 83.04 Quite High
opioid receptor 4 82.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 196 100.00 Very High Very High Very High
Stress 7 99.40 Very High Very High Very High
Fibromyalgia 6 99.34 Very High Very High Very High
Nicotine Addiction 366 99.32 Very High Very High Very High
Complex Regional Pain Syndromes 7 98.04 Very High Very High Very High
INFLAMMATION 80 97.76 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 44 97.60 Very High Very High Very High
Apoptosis 3 96.48 Very High Very High Very High
Disease 52 95.00 High High
Myocardial Reperfusion Injury 2 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PMNs of E and M subjects also exhibited a very marked and similar reduction in the expression of CD11b/CD18 integrin receptors after fMLP treatment with values that were lower than 10% of those in controls as observed by flow cytometry.
Negative_regulation (reduction) of Gene_expression (expression) of CD18
1) Confidence 0.57 Published 1996 Journal Recenti Prog Med Section Abstract Doc Link 9122534 Disease Relevance 0.32 Pain Relevance 0.40
As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis.
Negative_regulation (decreased) of Gene_expression (expression) of CD18 in plasma associated with stress and reflex sympathetic dystrophy
2) Confidence 0.42 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17702656 Disease Relevance 1.22 Pain Relevance 0.81
Polymorphonuclear (PMN) of H and M subjects also exhibited a very marked and similar reduction in the expression of CD11b/CD18 integrin receptors after fMLP treatment, with values that were less than 10% of those in controls, as observed by flow cytometry.
Negative_regulation (reduction) of Gene_expression (expression) of CD18
3) Confidence 0.41 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7868301 Disease Relevance 0.31 Pain Relevance 0.47
As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p < 0.01) and CD11b/CD18 (p < 0.05) on polymorphonuclear leukocytes.
Negative_regulation (decreased) of Gene_expression (expression) of CD18 in polymorphonuclear leukocytes associated with fibrositis
4) Confidence 0.41 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.78 Pain Relevance 0.39
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Negative_regulation (inhibited) of Gene_expression (expression) of CD18 in granulocytes
5) Confidence 0.41 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.38 Pain Relevance 0.37
Furthermore, a downregulation of the endothelial expression of the adhesion molecules ICAM-1 at the target site and LFA-1 on lymphocytes could also contribute to the absence of inflammatory cells in the neuraxis.
Negative_regulation (downregulation) of Gene_expression (expression) of LFA-1 in lymphocytes associated with inflammation and adhesions
6) Confidence 0.37 Published 1998 Journal Immunol. Lett. Section Abstract Doc Link 9840682 Disease Relevance 0.92 Pain Relevance 0.39
It is also possible that smoking may not affect all smokers equally, and that a differential effect on CD18/CD11b expression could discriminate smokers at increased risk of developing COPD.
Negative_regulation (effect) of Gene_expression (expression) of CD18 associated with nicotine addiction and chronic obstructive pulmonary disease
7) Confidence 0.22 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.27 Pain Relevance 0
It is also possible that smoking may not affect all smokers equally, and that a differential effect on CD18/CD11b expression could discriminate smokers at increased risk of developing COPD.
Negative_regulation (effect) of Gene_expression (expression) of CD18 associated with nicotine addiction and chronic obstructive pulmonary disease
8) Confidence 0.22 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.27 Pain Relevance 0
RESULTS: The expression of CD11b and CD18 on neutrophils and neutrophil-dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses, and the expression of ICAM-1 and VCAM-1 on endothelial cells and endothelial-dependent neutrophil adherence induced by IL-1beta were also inhibited by lansoprazole and omeprazole at similar doses.
Negative_regulation (inhibited) of Gene_expression (expression) of CD18 in neutrophil
9) Confidence 0.16 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807407 Disease Relevance 0.26 Pain Relevance 0
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Negative_regulation (inhibited) of in monocytes Gene_expression (expression) of CD18 in granulocytes
10) Confidence 0.14 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.38 Pain Relevance 0.37

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