INT53747

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 34
Total Number 42
Disease Relevance 29.03
Pain Relevance 13.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 13
hepatocyte 1
immune system 1
kidney 1
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 157 100.00 Very High Very High Very High
Inflammation 181 99.88 Very High Very High Very High
alcohol 164 99.84 Very High Very High Very High
chemokine 35 95.00 High High
cytokine 19 94.36 High High
halothane 2 87.88 High High
tolerance 20 87.76 High High
Analgesic 6 87.48 High High
Bile 42 82.28 Quite High
isoflurane 5 81.16 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 73 99.92 Very High Very High Very High
INFLAMMATION 178 99.88 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 447 99.84 Very High Very High Very High
Fatty Liver 614 99.80 Very High Very High Very High
Diabetes Mellitus 141 99.68 Very High Very High Very High
Targeted Disruption 66 99.64 Very High Very High Very High
Ketosis 8 99.48 Very High Very High Very High
Obesity 162 99.42 Very High Very High Very High
Alcoholic Liver Diseases 11 99.40 Very High Very High Very High
Shock 2 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral treatment of mice with BA resulted in a significant decrease in AP-induced CYP2E1 activity together with its inhibition of AP-induced CYP2EI expression.
Positive_regulation (induced) of CYP2E1 associated with paracetamol
1) Confidence 0.70 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.23 Pain Relevance 1.01
The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2.
Spec (examined) Positive_regulation (induce) of CYP2E1 associated with paracetamol
2) Confidence 0.69 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074700 Disease Relevance 0.17 Pain Relevance 0.70
Carbon tetrachloride pretreatment or partial hepatectomy decreased the hepatic xenobiotic-metabolizing enzyme activities in both sexes but elevated the renal p-nitrophenol hydroxylase, p-nitroanisole O-demethylase and aminopyrine N-demethylase activities significantly only in male mice.
Positive_regulation (elevated) of p-nitrophenol hydroxylase
3) Confidence 0.68 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17610925 Disease Relevance 0.67 Pain Relevance 0.07
Other mechanisms by which alcohol stimulates carcinogenesis include the induction of cytochrome P-4502E1, which is associated with enhanced production of free radicals and enhanced activation of various procarcinogens present in alcoholic beverages; a change in metabolism and in the distribution of carcinogens, in association with tobacco smoke and diet; alterations in cell-cycle behavior such as cell-cycle duration leading to hyperproliferation; nutritional deficiencies, for example, of methyl, vitamin E, folate, pyridoxal phosphate, zinc, and selenium; and alterations of the immune system.
Positive_regulation (induction) of cytochrome P-4502E1 in immune system associated with nicotine addiction, nutritional deficiencies and alcohol
4) Confidence 0.67 Published 2008 Journal Pharm Res Section Body Doc Link PMC2515569 Disease Relevance 1.16 Pain Relevance 0.40
The liver expresses many cytochrome P450 isoforms, including ethanol-induced CYP2E1.
Positive_regulation (induced) of CYP2E1 in liver
5) Confidence 0.67 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11812920 Disease Relevance 1.21 Pain Relevance 0.22
Considering the pathogenic role that up-regulation of CYP2E1 also plays in alcoholic liver disease (vide supra), it is apparent that a major therapeutic challenge is now to find a way to control this toxic process.
Positive_regulation (up-regulation) of CYP2E1 in liver associated with alcoholic liver diseases
6) Confidence 0.66 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 1.74 Pain Relevance 0.07
After chronic ethanol consumption, the activity of the MEOS increases, with an associated rise in cytochrome P450, especially CYP2E1, most conclusively shown in alcohol dehydrogenase negative deer mice.
Positive_regulation (increases) of CYP2E1 associated with alcohol
7) Confidence 0.66 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 0 Pain Relevance 0.28
Excess of these physiological substrates (such as seen in obesity and diabetes) also leads to CYP2E1 induction and nonalcoholic fatty liver disease (NAFLD), which includes nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH), with pathological lesions similar to those observed in alcoholic steatohepatitis.
Positive_regulation (induction) of CYP2E1 in liver associated with fatty liver, nash(non-alcoholic steatohepatitis), diabetes mellitus and obesity
8) Confidence 0.66 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 1.51 Pain Relevance 0.09
Increases of CYP2E1 and its mRNA prevail in the perivenular zone, the area of maximal liver damage.
Positive_regulation (Increases) of CYP2E1 in liver associated with hepatotoxicity
9) Confidence 0.66 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 1.74 Pain Relevance 0.05
CYP2E1 up-regulation was also demonstrated in obese patients as well as in rat models of obesity and NASH.
Positive_regulation (up-regulation) of CYP2E1 associated with nash(non-alcoholic steatohepatitis) and obesity
10) Confidence 0.66 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 1.79 Pain Relevance 0.05
However, microsomal CYP2E1 activity measured with p-nitrophenol and p-nitroanisole as substrates was increased by DMSO treatment.
Positive_regulation (increased) of CYP2E1
11) Confidence 0.65 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880615 Disease Relevance 0.24 Pain Relevance 0.99
Increases of CYP2E1 and its mRNA prevail in the perivenular zone, the area of maximal liver damage.
Positive_regulation (Increases) of CYP2E1 in liver associated with hepatotoxicity
12) Confidence 0.64 Published 1999 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 10397283 Disease Relevance 0.43 Pain Relevance 0.16
Importantly, hepatic CYP2E1 levels are increased in NASH patients [34].
Positive_regulation (increased) of CYP2E1 associated with nash(non-alcoholic steatohepatitis)
13) Confidence 0.62 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.95 Pain Relevance 0.04
in response to increased fatty acid load, impaired electron transport, and/or increased CYP2E1 in the HFD group would effectively decrease free NO concentrations in the cell via enhanced formation of ONOO?
Positive_regulation (increased) of CYP2E1
14) Confidence 0.62 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.38 Pain Relevance 0
It is likely that feeding a HFD increases CYP2E1 levels in response to elevated liver concentrations of ketones and fatty acids that serve as inducers and substrates of P450 enzymes [33].
Positive_regulation (increases) of CYP2E1 in liver
15) Confidence 0.62 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.99 Pain Relevance 0.04
These data suggest that APAP-mediated GSH depletion, covalent binding, and toxicity in the kidneys of testosterone-pretreated females results from increased APAP activation by the testosterone-induced renal CYP2E1.
Positive_regulation (induced) of CYP2E1 associated with toxicity and paracetamol
16) Confidence 0.59 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.44 Pain Relevance 0.97
Western blot analysis of microsomes showed that testosterone increased renal CYP2E1 levels without altering hepatic CYP2E1.
Positive_regulation (increased) of CYP2E1
17) Confidence 0.59 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.67 Pain Relevance 1.10
CYP2E1 P450 levels are increased in patients with NASH because fatty acids and ketone bodies including acetone, which increased in diabetes/ketosis [96], are substrates and inducers of CYP2E1 protein.
Positive_regulation (increased) of CYP2E1 associated with nash(non-alcoholic steatohepatitis), ketosis and diabetes mellitus
18) Confidence 0.58 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.14 Pain Relevance 0.08
The ethanol-inducible CYP2E1 is elevated in both rodent experimental models of steatosis and steatohepatitis and human NAFLD patients, and in vivo levels of CYP2E1 activation correlate with the severity of liver damage, suggesting that this P450 is one of the major microsomal contributors of ROS-induced hepatic injury [6, 98].
Positive_regulation (elevated) of CYP2E1 in liver associated with fatty liver, injury and hepatotoxicity
19) Confidence 0.58 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.34 Pain Relevance 0
The induction of CYP2E1 by many potentially toxic/carcinogenic substrates such as ethanol, benzene, and haloalkanes and their metabolisms promote ROS production [6].
Positive_regulation (induction) of CYP2E1
20) Confidence 0.58 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.25 Pain Relevance 0

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