INT53950

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 9.40
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
cardiomyocyte 2
macrophages 1
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 42 99.10 Very High Very High Very High
Spinal cord 8 92.72 High High
Inflammation 12 79.16 Quite High
cINOD 3 74.24 Quite High
Inflammatory response 1 70.84 Quite High
Inflammatory stimuli 1 66.84 Quite High
ketamine 4 55.12 Quite High
anesthesia 9 50.32 Quite High
Perioperative pain 3 39.44 Quite Low
Buprenorphine 3 37.12 Quite Low
Disease Link Frequency Relevance Heat
Cancer 373 99.44 Very High Very High Very High
Apoptosis 294 99.30 Very High Very High Very High
Myocardial Infarction 234 99.12 Very High Very High Very High
Fibrosis 36 99.10 Very High Very High Very High
Death 35 99.02 Very High Very High Very High
Hypertrophy 42 98.36 Very High Very High Very High
Glioblastoma 152 97.84 Very High Very High Very High
Cardiovascular Disorder Under Development 6 94.36 High High
Coronary Heart Disease 30 92.52 High High
Diabetes Mellitus 165 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Radicicol inhibited tyrosine phosphorylation of p53/56lyn, a Src family tyrosine kinase and one of the major tyrosine-phosphorylated proteins in LPS-stimulated macrophages.
Phosphorylation (phosphorylation) of p53 in macrophages
1) Confidence 0.61 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7890656 Disease Relevance 0.45 Pain Relevance 0.18
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Phosphorylation (phosphorylation) of p53 in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
2) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.49 Pain Relevance 0.17
Western blotting was used to study Caspase-3, Bax, Sirt1, acetylation of p53 and phosphorylation of p38, Akt and FOXO3a.
Phosphorylation (phosphorylation) of p53
3) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.48 Pain Relevance 0.09
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Phosphorylation (phosphorylation) of p53 in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
4) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.48 Pain Relevance 0.12
To investigate apoptotic pathways induced by BP treatment, phosphorylation of p53 and Rb proteins were first evaluated by immunoblotting.
Phosphorylation (phosphorylation) of p53 associated with apoptosis
5) Confidence 0.12 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.93 Pain Relevance 0
BP caused levels of phosphorylated p53 protein to increase (9.4-fold) 3 h after treatment (Fig. 2a).
Phosphorylation (phosphorylated) of p53
6) Confidence 0.12 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.72 Pain Relevance 0
WOX1 is essential for p53-mediated cell death through binding and stabilizing
               phosphorylated p53 [7]. 
Phosphorylation (phosphorylated) of p53 associated with death
7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.75 Pain Relevance 0.05
Several studies have shown that IGF-1 suppresses the action of p53 that is phosphorylated and stabilized when defects are found in DNA.
Phosphorylation (phosphorylated) of p53
8) Confidence 0.10 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538507 Disease Relevance 0.48 Pain Relevance 0
First, the p53-dependent apoptosis pathway was supposed because BP treatment could promote the phosphorylation of p53 in the DBTRG tumor cells and increase p53 expression, which peaked at 12 h (Fig. 2a).
Phosphorylation (phosphorylation) of p53 associated with cancer and apoptosis
9) Confidence 0.09 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.76 Pain Relevance 0
Phosphorylation at the N-terminal region of p53 abolishes Mdm2 inhibition, which causes an increase in Bax transcription (Fig. 2c shows that Bax proteins were increased) and an inhibition of Bcl-2 transcription.
Phosphorylation (Phosphorylation) of p53
10) Confidence 0.09 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.86 Pain Relevance 0

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