INT54072

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.04
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GAP43) plasma membrane (GAP43)
Anatomy Link Frequency
neuronal 4
nerve 2
retinal ganglion cells 2
Optic nerve 1
neural 1
GAP43 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 15 100.00 Very High Very High Very High
noradrenaline 1 99.90 Very High Very High Very High
Pain 22 99.64 Very High Very High Very High
Chronic pancreatitis 18 99.04 Very High Very High Very High
substance P 17 98.84 Very High Very High Very High
Calcitonin gene-related peptide 3 98.00 Very High Very High Very High
Pain score 2 92.56 High High
adenocard 2 89.04 High High
Nerve growth factor 54 84.24 Quite High
Dorsal column 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Glaucoma 364 99.84 Very High Very High Very High
Pain 18 99.64 Very High Very High Very High
Ganglion Cysts 92 99.52 Very High Very High Very High
Pancreatitis 20 99.04 Very High Very High Very High
Frailty 8 98.40 Very High Very High Very High
Syndrome 8 97.90 Very High Very High Very High
Sprains And Strains 8 96.92 Very High Very High Very High
Malignant Neoplastic Disease 19 92.12 High High
Disorder Of Lipid Metabolism 4 88.24 High High
Neuroblastoma 27 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By means of immunohistochemistry the presence of the growth-associated protein GAP-43 and its codistribution with substance P (SP) and calcitonin gene-related peptide (CGRP) are studied in the human spinal trigeminal, gracile, and cuneate nuclei at perinatal and adult life stages.
Gene_expression (presence) of GAP-43 in spinal associated with calcitonin gene-related peptide and substance p
1) Confidence 0.67 Published 1995 Journal Ital J Anat Embryol Section Abstract Doc Link 11322293 Disease Relevance 0 Pain Relevance 0.33
Expression of GAP-43 was increased in the non-acute appendices.
Gene_expression (Expression) of GAP-43 in appendices
2) Confidence 0.57 Published 1999 Journal Lancet Section Body Doc Link 10465170 Disease Relevance 0 Pain Relevance 0
The increase in the density of growth-associated protein-43 immunoreactive nerve fibres in enlarged nerve trunks paralleled by augmented expression of growth-associated protein-43 in intrinsic neurons and reduced parenchymal growth-associated protein-43-immunoreactive innervation underline the dramatic plasticity of pancreatic innervation in chronic pancreatitis.
Gene_expression (expression) of growth-associated protein-43 in intrinsic neurons associated with chronic pancreatitis
3) Confidence 0.53 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898650 Disease Relevance 0.39 Pain Relevance 0.28
The expression of growth-associated protein-43 in the terminal fields of pancreatic nerve suggests that the innervation of the normal human pancreas undergoes continual and toposelective remodelling.
Gene_expression (expression) of growth-associated protein-43 in nerve
4) Confidence 0.53 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898650 Disease Relevance 0.47 Pain Relevance 0.33
Importantly, these innervating fibres have been shown to express both the neural growth-associated marker GAP43 and the pain-associated neuropeptide substance P [5].
Gene_expression (express) of GAP43 in neural associated with pain, neuropeptide and substance p
5) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.17 Pain Relevance 0.41
Axonal elongation and synaptic plasticity genes, including growth-associated protein 43 (GAP43), neurofilament heavy (NEFH), and neuritin 1 (NRN1), preferentially expressed by retinal ganglion cells, indicated an attempt to re-extend lost or damaged axons.
Gene_expression (expressed) of GAP43 in retinal ganglion cells associated with ganglion cysts
6) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.43 Pain Relevance 0
Optic nerve astrocytes expressed abundant GAP-43 in ExpG.
Gene_expression (expressed) of GAP-43 in Optic nerve associated with glaucoma
7) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.95 Pain Relevance 0
Axonal elongation and synaptic plasticity genes, including growth-associated protein 43 (GAP43), neurofilament heavy (NEFH), and neuritin 1 (NRN1), preferentially expressed by retinal ganglion cells, indicated an attempt to re-extend lost or damaged axons.
Gene_expression (expressed) of growth-associated protein 43 in retinal ganglion cells associated with ganglion cysts
8) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.44 Pain Relevance 0
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Gene_expression (expression) of GAP43 in neuronal
9) Confidence 0.48 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
GPNMB was chosen because it is a null mutation in the DBA/2J mouse strain, which develops iris pigment dispersion syndrome and iris stromal atrophy; the former was mapped to a premature stop mutation in GPNMB [64,65]; NEFH and GAP43 were chosen because they are markers of axonal regrowth [66,67], which has not been previously described in a primate glaucoma model.
Gene_expression (chosen) of GAP43 in iris associated with syndrome, frailty, glaucoma and sprains and strains
10) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.53 Pain Relevance 0
Treatment of this cell line with phorbol esters leads to sympathetic neuronal differentiation with neurite outgrowth and increased synthesis of noradrenaline and expression of neuropeptide Y and growth-associated protein 43 (GAP-43) [22].
Gene_expression (expression) of neuropeptide Y and growth-associated protein 43 in neuronal associated with neuropeptide and noradrenaline
11) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2841252 Disease Relevance 0.85 Pain Relevance 0.10
BACKGROUND & AIMS: Changes in innervation pattern and neuropeptide content have been shown in chronic pancreatitis (CP), including increased neuronal expression of growth-associated protein 43 (GAP-43).
Gene_expression (expression) of growth-associated protein 43 in neuronal associated with neuropeptide and chronic pancreatitis
12) Confidence 0.24 Published 1997 Journal Gastroenterology Section Abstract Doc Link 9136844 Disease Relevance 0.35 Pain Relevance 0.58
We used standard immunohistochemical techniques to test for a general nerve marker, a nociceptive neurotransmitter (substance P), and a protein expressed during axonogenesis (growth-associated protein 43 [GAP43]).
Gene_expression (expressed) of growth-associated protein 43 in nerve
13) Confidence 0.22 Published 1997 Journal Lancet Section Body Doc Link 9250186 Disease Relevance 0.08 Pain Relevance 0
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Gene_expression (express) of GAP43 in neuronal
14) Confidence 0.21 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis.
Gene_expression (expression) of growth-associated protein 43 in Immune cell associated with pain and chronic pancreatitis
15) Confidence 0.16 Published 1997 Journal Gastroenterology Section Title Doc Link 9136844 Disease Relevance 0.39 Pain Relevance 0.71

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