INT5415

Context Info Confidence 0.36 First Reported 1991 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 0.94 Pain Relevance 1.93

isomerase activity (Pdia4) endoplasmic reticulum (Pdia4)

Anatomy Link Frequency cardiomyocytes 1 Pdia4 (Mus musculus)

Pain Link Frequency Relevance Heat tetrodotoxin 4 100.00 Pain 1 99.98 agonist 6 99.26 Opioid 3 99.14 opioid receptor 2 99.10 antagonist 3 98.24 Enkephalin 9 93.60 narcan 4 93.20 lidocaine 2 90.08 MU agonist 1 80.96

Disease Link Frequency Relevance Heat Pain 1 99.98 Neuroblastoma 1 90.64 Cancer 4 81.84 Pancreatic Cancer 5 77.52 Metastasis 3 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, we observed pain reduction in nearly all patients under CAI.

Negative_regulation (reduction) of CAI associated with pain

1) Confidence 0.36 Published 1999 Journal World J Surg Section Abstract Doc Link 10449825 Disease Relevance 0.85 Pain Relevance 0.17

The Cai plateau was reduced to resting levels by either the muscarinic antagonist atropine (1 microM) or the inorganic Ca2+ channel blocker lanthanum (effective concentration for 50% inhibition of Cai plateau EC50 = 68 +/- 18 nM), but it was unaffected by the organic Ca2+ channel blockers verapamil and nifedipine.

Negative_regulation (inhibition) of Cai associated with antagonist

2) Confidence 0.06 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1437524 Disease Relevance 0 Pain Relevance 0.21

The Cai plateau was reduced to resting levels by either the muscarinic antagonist atropine (1 microM) or the inorganic Ca2+ channel blocker lanthanum (effective concentration for 50% inhibition of Cai plateau EC50 = 68 +/- 18 nM), but it was unaffected by the organic Ca2+ channel blockers verapamil and nifedipine.

Negative_regulation (reduced) of Cai associated with antagonist

3) Confidence 0.04 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1437524 Disease Relevance 0 Pain Relevance 0.20

In rat ventricular cardiomyocytes loaded with the fluorescent Ca2+ indicator Indo-1/AM, the delta opioid receptor agonist Leu-Enk caused Cai oscillations and abolished the caffeine-induced Cai transient.

Negative_regulation (abolished) of Cai in cardiomyocytes associated with agonist and opioid receptor

4) Confidence 0.04 Published 1991 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 1657046 Disease Relevance 0 Pain Relevance 0.48

Thus, delta and kappa but not mu opioids have a negative inotropic action due to a decreased Cai transient.

Negative_regulation (decreased) of Cai associated with opioid

5) Confidence 0.03 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1309318 Disease Relevance 0.09 Pain Relevance 0.54

In four cells, the Cai transient remaining in the presence of nifedipine plus TTX was abolished by adding 5 mM Ni.

Negative_regulation (abolished) of Cai associated with tetrodotoxin

6) Confidence 0.02 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8594540 Disease Relevance 0 Pain Relevance 0.33

General Comments

This test has worked.