INT54190

Context Info Confidence 0.34 First Reported 1993 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.28 Pain Relevance 1.47

intracellular (Gnai1) GTPase activity (Gnai1) cytoplasm (Gnai1) signal transducer activity (Gnai1) signal transduction (Gnai1) nucleus (Gnai1)

Gnai1 (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 1 99.16 Pain threshold 2 98.48 Antihistamine 4 94.56 antinociception 5 93.68 agonist 2 92.48 Potency 1 91.20 Antinociceptive 2 89.96 Opioid 4 87.32 Morphine 1 85.88 tail-flick 1 78.64

Disease Link Frequency Relevance Heat Pain 2 98.48 Urological Neuroanatomy 1 98.40 Bordatella Infection 1 80.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pretreatment with anti-Gi alpha(1) (12.5 microg per mouse i.c.v.), anti-Gi alpha(2) (25 microg per mouse i.c.v.) and anti-Gi alpha(3) (25 microg per mouse i.c.v.), administered 24 and 18 h before test, prevented the antihistamine-induced antinociception.

anti-Gi alpha Binding (Pretreatment) of associated with antinociception and antihistamine

1) Confidence 0.34 Published 2002 Journal Neuroscience Section Abstract Doc Link 11927163 Disease Relevance 0.10 Pain Relevance 0.57

Anti-Gi2 alpha and anti-Gx/z alpha, but not anti-Gi1 alpha, reduced the specific binding of [3H]DAMGO to the opioid receptor in PAG.

anti-Gi1 alpha Binding (binding) of associated with urological neuroanatomy and opioid receptor

2) Confidence 0.05 Published 1993 Journal Life Sci. Section Abstract Doc Link 7902522 Disease Relevance 0.18 Pain Relevance 0.90

General Comments

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