INT54272

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Context Info
Confidence 0.30
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.42
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) molecular_function (Insig1) cellular_component (Insig1)
Anatomy Link Frequency
neurons 2
forebrain 1
dorsal root ganglion 1
Insig1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 4 99.98 Very High Very High Very High
dopamine receptor 6 99.80 Very High Very High Very High
Opioid 1 99.60 Very High Very High Very High
Enkephalin 16 99.44 Very High Very High Very High
Inflammation 14 98.92 Very High Very High Very High
dorsal root ganglion 23 98.60 Very High Very High Very High
Neuropathic pain 29 96.16 Very High Very High Very High
Inflammatory mediators 2 95.76 Very High Very High Very High
Dopamine 4 83.68 Quite High
agonist 10 79.16 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 22 100.00 Very High Very High Very High
Cytomegalovirus Infection 6 100.00 Very High Very High Very High
INFLAMMATION 17 98.92 Very High Very High Very High
Ganglion Cysts 24 98.12 Very High Very High Very High
Herpes Simplex Virus 3 97.40 Very High Very High Very High
Neuropathic Pain 40 96.16 Very High Very High Very High
Disease 1 95.92 Very High Very High Very High
Convulsion 3 94.52 High High
Injury 18 92.00 High High
Brain Injury 1 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Convulsant doses of cocaine alter immediate early gene and opioid peptide expression in rat limbic forebrain.
Regulation (alter) of immediate early in forebrain associated with enkephalin, opioid and cocaine
1) Confidence 0.30 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7905595 Disease Relevance 0.18 Pain Relevance 0.48
D1- and D2-dopamine receptor-mediated regulation of immediate early gene levels in identified populations of neurons in the striatum was examined with quantitative in situ hybridization histochemical techniques.
Regulation (regulation) of immediate early in neurons associated with dopamine receptor
2) Confidence 0.05 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 8613751 Disease Relevance 0 Pain Relevance 0.23
D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons.
Regulation (response) of immediate early in neurons associated with dopamine receptor
3) Confidence 0.02 Published 1995 Journal J. Neurosci. Section Title Doc Link 8613751 Disease Relevance 0 Pain Relevance 0.52
To examine the role of inflammatory mediators in neuropathic pain, we used a replication-defective genomic herpes simplex virus (HSV)-based vector containing the coding sequence for the anti-inflammatory peptide interleukin (IL)-4 under the transcriptional control of the HSV ICP4 immediate early promoter, vector S4IL4, to express IL-4 in dorsal root ganglion (DRG) neurons in vivo.


Regulation (control) of immediate early promoter in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, inflammatory mediators, cold sores, inflammation, herpes simplex virus and neuropathic pain
4) Confidence 0.01 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1395302 Disease Relevance 1.42 Pain Relevance 0.91
In this study, the Cu/Zn SOD transgene was expressed under the control of the cytomegalovirus immediate early promoter and as such, expressed in any cell type.
Regulation (control) of immediate early promoter associated with cytomegalovirus infection
5) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1462999 Disease Relevance 0.82 Pain Relevance 0

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