INT54356

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 48
Total Number 53
Disease Relevance 5.86
Pain Relevance 15.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
plasma 2
brain 2
neuronal 2
striatum 1
prefrontal 1
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2055 100.00 Very High Very High Very High
antidepressant 61 100.00 Very High Very High Very High
Kinase C 294 99.98 Very High Very High Very High
noradrenaline 21 99.70 Very High Very High Very High
sodium channel 8 99.64 Very High Very High Very High
Nicotine 17 99.58 Very High Very High Very High
dopamine receptor 69 99.56 Very High Very High Very High
Serotonin 75 99.54 Very High Very High Very High
cocaine 76 99.24 Very High Very High Very High
Enkephalin 7 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 63 100.00 Very High Very High Very High
Depression 128 98.68 Very High Very High Very High
Stress 78 98.22 Very High Very High Very High
Sprains And Strains 34 97.44 Very High Very High Very High
Disease 153 96.68 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 360 96.24 Very High Very High Very High
Drug Dependence 51 96.00 Very High Very High Very High
Obesity 37 95.24 Very High Very High Very High
Manic Depressive Disorder 10 94.08 High High
Syndrome 31 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these data suggest that activation of sigma(2)-receptors results in the regulation of DAT activity via a calcium- and protein kinase C-dependent signaling mechanism.
Regulation (regulation) of DAT associated with kinase c
1) Confidence 0.58 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11907188 Disease Relevance 0 Pain Relevance 0.73
Moreover, other yet-to-be-identified proteins may also play a role in regulating DAT function.
Regulation (regulating) of DAT
2) Confidence 0.51 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.34
Among them, the best characterized form of DAT regulation is phosphorylation [32].
Regulation (regulation) of DAT
3) Confidence 0.51 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.10
Alternatively, there is evidence that PKC- mediated functional regulation of DAT is not achieved by direct phosphorylation of the DAT protein [58], as has been demonstrated for the GABA transporter, where PKC down regulates transporter function by modulating the association of syntaxin with the transporter [59].
Regulation (regulation) of DAT associated with gaba and kinase c
4) Confidence 0.51 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.33
Several studies have shown that regulation of kinase activity in striatal synaptosomal preparations and heterologous cell expression systems affects DAT uptake activity [12], which is believed to result from a rapid redistribution of transporter from the cell membrane to intracellular compartments, rather than changes in the intrinsic transport activity [31,37,53,54].
Regulation (affects) of DAT
5) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.13
Considering that the striatum is highly enriched in insulin [17,62] and IRs [15,17,18], as well as in DAT [37–39], these studies strongly support a role for the neuronal PI3K pathway in regulating DAT activity and extracellular DA levels, as well as in the actions of AMPH.
Regulation (regulating) of DAT in neuronal associated with dopamine
6) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.36 Pain Relevance 0.28
Previous studies in our laboratory have demonstrated sigma(2)-receptor-mediated regulation of the dopamine transporter (DAT) as measured by amphetamine-stimulated release of [(3)H]dopamine (DA) from both rat striatal slices and PC12 cells.
Regulation (regulation) of DAT associated with dopamine
7) Confidence 0.43 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11907188 Disease Relevance 0 Pain Relevance 0.29
Previous studies in our laboratory have demonstrated sigma(2)-receptor-mediated regulation of the dopamine transporter (DAT) as measured by amphetamine-stimulated release of [(3)H]dopamine (DA) from both rat striatal slices and PC12 cells.
Regulation (regulation) of dopamine transporter associated with dopamine
8) Confidence 0.43 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11907188 Disease Relevance 0 Pain Relevance 0.29
In conclusion, part of the TsTX-induced release [3H] dopamine may be due to an effect of the toxin on the reversal of the dopamine transporter (DAT), but the majority of the toxin stimulated release of [3H] dopamine involves the mobilization of intracellular calcium stores.
Regulation (effect) of DAT associated with dopamine
9) Confidence 0.39 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 12971911 Disease Relevance 0 Pain Relevance 0.46
In conclusion, part of the TsTX-induced release [3H] dopamine may be due to an effect of the toxin on the reversal of the dopamine transporter (DAT), but the majority of the toxin stimulated release of [3H] dopamine involves the mobilization of intracellular calcium stores.
Regulation (effect) of dopamine transporter associated with dopamine
10) Confidence 0.39 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 12971911 Disease Relevance 0 Pain Relevance 0.46
Thus, changes in both cell surface and total DAT levels may reflect changes in DAT protein turnover rates in the presence of CPE.
Regulation (changes) of DAT
11) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
It remains to be determined in which cellular compartment this interaction occurs and the details of mechanisms involved that may regulate the CPE-DAT interaction.
Spec (may) Regulation (regulate) of CPE-DAT
12) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.18 Pain Relevance 0.10
Recent reports show that DAT can be regulated by endocytosis [50,64-67].
Regulation (regulated) of DAT
13) Confidence 0.35 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0.28 Pain Relevance 0.05
Functional assays showed that the increased surface DAT led to a corresponding increase in DA uptake but had no effect on DAT affinity for DA.
Neg (no) Regulation (effect) of DAT associated with dopamine
14) Confidence 0.32 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.16
Thus, changes in both cell surface and total DAT levels may reflect changes in DAT protein turnover rates in the presence of CPE.
Regulation (changes) of DAT protein
15) Confidence 0.32 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
Recent studies using yeast two-hybrid approaches have successfully identified several proteins that interact with the DAT carboxyl terminus and influence DAT trafficking [16-18].
Regulation (influence) of DAT
16) Confidence 0.32 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.11 Pain Relevance 0.06
We concluded that CPE-mediated modulation of DAT trafficking, membrane expression and phosphorylation was facilitated by the CPE-DAT physical coupling.
Regulation (modulation) of DAT
17) Confidence 0.32 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.13
The increasing reports of proteins that interact with DAT [7,19-26] and their roles in the modulation of physiological and pathological DAT functions stress the importance to understand the molecular mechanisms of how these interaction proteins affect DAT metabolic cycle and trafficking.
Regulation (affect) of DAT associated with stress
18) Confidence 0.32 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.28 Pain Relevance 0.04
This property of amphetamine relies on its actions at the dopamine transporter (DAT), a presynaptic plasma membrane protein that is responsible for the reuptake of extracellular dopamine.
Regulation (responsible) of DAT in plasma associated with dopamine
19) Confidence 0.32 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0.08 Pain Relevance 0.26
STZ treatment does not significantly influence total DAT number or DA affinity [12,14].
Neg (not) Regulation (influence) of DAT associated with dopamine
20) Confidence 0.32 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.59

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