INT54363

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.80
Pain Relevance 7.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1d) signal transducer activity (Htr1d)
Anatomy Link Frequency
entopeduncular nucleus 1
saphenous vein 1
cranial 1
subthalamic nucleus 1
caudate-putamen 1
Htr1d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 11 99.84 Very High Very High Very High
Periaqueductal grey 55 98.50 Very High Very High Very High
Trigeminal ganglion neurons 4 98.50 Very High Very High Very High
Analgesic 10 97.80 Very High Very High Very High
Triptan 15 97.40 Very High Very High Very High
cocaine 105 96.92 Very High Very High Very High
Dorsal horn 8 96.44 Very High Very High Very High
headache 5 96.16 Very High Very High Very High
Migraine 14 95.44 Very High Very High Very High
Spinal cord 7 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 11 98.70 Very High Very High Very High
Urological Neuroanatomy 55 98.50 Very High Very High Very High
Eating Disorder 12 98.36 Very High Very High Very High
Ganglion Cysts 16 98.34 Very High Very High Very High
Headache 15 96.16 Very High Very High Very High
Migraine Disorders 2 95.80 Very High Very High Very High
Pain 11 95.36 Very High Very High Very High
Nociception 4 94.80 High High
Cluster Headache 4 93.76 High High
Stress 2 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible explanation for this difference is that 5-HT1D receptors are preferentially expressed by cranial afferents of the trigeminal system.
Gene_expression (expressed) of 5-HT1D in cranial
1) Confidence 0.75 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14645495 Disease Relevance 0.62 Pain Relevance 0.90
Our finding, that 5-HT1D receptors are distributed in nociceptors throughout the body, raises the possibility that triptans can regulate not only headache-associated pain but also nociceptive responses in extracranial tissues.
Gene_expression (distributed) of 5-HT1D in nociceptors associated with nociception, pain, nociceptor, triptan and headache
2) Confidence 0.65 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14645495 Disease Relevance 0.71 Pain Relevance 1.08
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Gene_expression (densities) of 5-HT1D in substantia nigra associated with substantia nigra
3) Confidence 0.65 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.33
The PAG contains a dense plexus of serotonergic nerve terminals [20], and varying levels of 5-HT1A, 5-HT1B, 5-HT1D and 5-HT1F receptor mRNA and protein has been found in different species [21-25].
Gene_expression (levels) of 5-HT1D in nerve associated with periaqueductal grey
4) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.83 Pain Relevance 1.39
Resequencing of the HTR1D locus and a portion of the OPRD1 locus identified novel SNPs and confirmed existing SNPs.
Gene_expression (Resequencing) of HTR1D
5) Confidence 0.55 Published 2003 Journal Mol. Psychiatry Section Abstract Doc Link 12740597 Disease Relevance 0.86 Pain Relevance 0.25
Arc, Beta-catenin, Cap2, Crip2, Dnm2, Egr2, Fos, Fut8, GFAP, Gpr88, Htr1d, and Nr4a1 were all confirmed by qPCR to be differentially expressed.
Gene_expression (expressed) of Htr1d associated with aids-related complex
6) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.26 Pain Relevance 0.46
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Gene_expression (densities) of 5-HT1D in pallidum associated with substantia nigra
7) Confidence 0.22 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.33
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Gene_expression (densities) of 5-HT1D in subthalamic nucleus associated with substantia nigra
8) Confidence 0.22 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.33
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Gene_expression (densities) of 5-HT1D in entopeduncular nucleus associated with substantia nigra
9) Confidence 0.22 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.33
Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures.
Gene_expression (densities) of 5-HT1D in caudate-putamen associated with substantia nigra
10) Confidence 0.22 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.33
Approximately 46% of the 5-HT1B-positive and 43% of the 5-HT1D-positive trigeminal ganglion neurons were also NF200 positive, indicating that many A-fibre trigeminal neurons express 5-HT1B or 5-HT1D receptors.
Gene_expression (express) of 5-HT1D in neurons associated with ganglion cysts and trigeminal ganglion neurons
11) Confidence 0.14 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422450 Disease Relevance 0.52 Pain Relevance 1.13
Thus, the 5-HT1D receptor is expressed in canine coronary artery and saphenous vein and taken together with the pharmacological data, supports the possibility that a 5-HT1D-like receptor mediates contraction in these two tissues.
Gene_expression (expressed) of 5-HT1D in saphenous vein
12) Confidence 0.02 Published 1994 Journal Life Sci. Section Abstract Doc Link 7909909 Disease Relevance 0 Pain Relevance 0.37
Thus, the 5-HT1D receptor is expressed in canine coronary artery and saphenous vein and taken together with the pharmacological data, supports the possibility that a 5-HT1D-like receptor mediates contraction in these two tissues.
Gene_expression (expressed) of 5-HT1D in coronary artery
13) Confidence 0.01 Published 1994 Journal Life Sci. Section Abstract Doc Link 7909909 Disease Relevance 0 Pain Relevance 0.37

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